☆ 4.5 Article

Exploring the mechanism of action of Qian Lie Xing Fang during the treatment of benign prostatic hyperplasia via network pharmacology and molecular dynamics simulation analyses

MEDICINE (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Pharmacology & Pharmacy

Application of Box-Behnken Design in the Preparation, Optimization, and In-Vivo Pharmacokinetic Evaluation of Oral Tadalafil-Loaded Niosomal Film

Kawthar K. Abla et al.

Summary: This study developed and evaluated an oral fast dissolving film containing tadalafil-loaded niosomes for the treatment of benign prostatic hyperplasia (BPH). The optimized niosomes showed high entrapment efficiency and the film had desirable characteristics. The tadalafil-loaded niosomal film demonstrated faster release and enhanced bioavailability compared to the marketed tablet.

PHARMACEUTICS (2023)

添加到收藏夹

Article Pharmacology & Pharmacy

The Physiological and Pathophysiological Role of IL-6/STAT3-Mediated Signal Transduction and STAT3 Binding Partners in Therapeutic Applications

Tadashi Matsuda

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2023)

添加到收藏夹

Review Oncology

Research progress and clinical evaluation of histotripsy: a narrative review

Shuaiqi Li et al.

Summary: This paper aims to explain the mechanism of histotripsy, summarize the research progress of animal models for clinical evaluation and application, and analyze the advantages and limitations of histotripsy. Histotripsy is a noninvasive, nonionizing, nonthermal ablation technique. Significant progress has been made in the clinical application of histotripsy in the treatment of liver tumors, benign prostatic hyperplasia, and aortic valve calcification stenosis.

ANNALS OF TRANSLATIONAL MEDICINE (2023)

添加到收藏夹

Article Plant Sciences

Deciphering anti-benign prostatic hyperplasia potential of liangwanoside II based on metabolite profile characterization combined with targeted network pharmacology

Li Fan et al.

Summary: This study revealed the anti-benign prostate hyperplasia (BPH) potential of liangwanoside II through in vivo experiments. Liangwanoside II showed anti-BPH effects by reducing prostate weight, prostate index, and serum prostatic acid phosphatase level, and improving prostate tissue morphology. Metabolite profile characterization and targeted network pharmacology provided insights into the mechanism of action, suggesting that liangwanoside II and its metabolites inhibit inflammation reaction and hormone imbalance, reduce oxidative stress damage, and restore the balance between cell proliferation and apoptosis.

JOURNAL OF ETHNOPHARMACOLOGY (2023)

添加到收藏夹

Article Andrology

The mechanism of Lingze tablets in the treatment of benign prostatic hyperplasia based on network pharmacology and molecular docking technology

Chen Shaofeng et al.

Summary: The study investigated the mechanism of Lingze tablets in the treatment of BPH through network pharmacology and molecular docking technology. It was found that the tablets regulate disease targets like SRC, MAPK1, PIK3CA, and JAK2, intervening in biological processes such as cell migration, cell activity, cytokine secretion, protein phosphorylation, and signaling pathways like MAPK, transferase activity and PI3K/AKT in the treatment of BPH.

ANDROLOGIA (2022)

添加到收藏夹

Article Medicine, Research & Experimental

Hesperidin prevents hyperglycemia in diabetic rats by activating the insulin receptor pathway

Peng Peng et al.

Summary: The study demonstrated that hesperidin has a preventive effect against type 2 diabetes and insulin resistance by improving insulin sensitivity and regulating hepatic glucose metabolism pathways.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

添加到收藏夹

Article Chemistry, Medicinal

Inhibitory Effect of Astaxanthin on Testosterone-Induced Benign Prostatic Hyperplasia in Rats

Liping Wang et al.

Summary: This study found that astaxanthin (AST) may have an inhibitory effect on testosterone-induced benign prostatic hyperplasia in rats by regulating superoxide dismutase (SOD) activity and testosterone (T) and dihydrotestosterone (DHT) levels.

MARINE DRUGS (2021)

添加到收藏夹

Review Oncology

IL-6/STAT3 Is a Promising Therapeutic Target for Hepatocellular Carcinoma

Junnv Xu et al.

Summary: IL-6 plays a crucial role in the occurrence and development of hepatocellular carcinoma (HCC), and targeting the IL-6/STAT3 signaling pathway is essential for therapy. Several inhibitors of IL-6/STAT3 have been developed for cancer treatment.

FRONTIERS IN ONCOLOGY (2021)

添加到收藏夹

Article Urology & Nephrology

Current surgical procedures for benign prostatic hyperplasia and impression of new surgical modalities

Abdullah M. Al Khayal et al.

Summary: The study found that TURP remains the main intervention for prostate sizes <100 g in Saudi Arabia, while open prostatectomy is widely used for prostate sizes more than 100 g. New modalities have gained little acceptance among urologists practicing in the country. Hands-on workshops may help in educating urologists and introducing these new modalities for future use.

UROLOGY ANNALS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

PubChem in 2021: new data content and improved web interfaces

Sunghwan Kim et al.

Summary: PubChem, a popular chemical information resource, has made substantial improvements in the past two years by adding data from over 100 new sources, updating its homepage and record pages, introducing new services like the Periodic Table and Pathway pages, and creating a special data collection related to COVID-19 and SARS-CoV-2 in response to the pandemic.

NUCLEIC ACIDS RESEARCH (2021)

添加到收藏夹

Review Medicine, Research & Experimental

Molecular mechanisms of action of hesperidin in cancer: Recent trends and advancements

Vaishali Aggarwal et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2020)

添加到收藏夹

Review Nutrition & Dietetics

Effect of Hesperidin on Cardiovascular Disease Risk Factors: The Role of Intestinal Microbiota on Hesperidin Bioavailability

Anna Mas-Capdevila et al.

NUTRIENTS (2020)

添加到收藏夹

Article Urology & Nephrology

The New American Urological Association Benign Prostatic Hyperplasia Clinical Guidelines: 2019 Update

Ryan Dornbier et al.

CURRENT UROLOGY REPORTS (2020)

添加到收藏夹

Review Urology & Nephrology

The role of the androgen receptor in prostate development and benign prostatic hyperplasia: A review

Renee E. Vickman et al.

ASIAN JOURNAL OF UROLOGY (2020)

添加到收藏夹

Review Integrative & Complementary Medicine

Benefits of Hesperidin for Cutaneous Functions

Mao-Qiang Man et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2019)

添加到收藏夹

Correction Pharmacology & Pharmacy

Berberine Improves Benign Prostatic Hyperplasia via Suppression of 5 Alpha Reductase and Extracellular Signal-Regulated Kinase in Vivo and in Vitro (vol 9, 773, 2018)

Dong-Hyun Youn et al.

FRONTIERS IN PHARMACOLOGY (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

Yingyao Zhou et al.

NATURE COMMUNICATIONS (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Network pharmacology applications to map the unexplored target space and therapeutic potential of natural products

Milla Kibble et al.

NATURAL PRODUCT REPORTS (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

SwissTargetPrediction: a web server for target prediction of bioactive small molecules

David Gfeller et al.

NUCLEIC ACIDS RESEARCH (2014)

添加到收藏夹

Article Biochemical Research Methods

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

Da Wei Huang et al.

NATURE PROTOCOLS (2009)

添加到收藏夹

Review Biochemistry & Molecular Biology

Network pharmacology: the next paradigm in drug discovery

Andrew L. Hopkins

NATURE CHEMICAL BIOLOGY (2008)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.