期刊
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
卷 61, 期 11, 页码 3049-3066出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s11517-023-02907-x
关键词
Volume change; Pulmonary lobectomy; Computed tomography
Lobectomy is an effective therapy for lung cancer, and this study assessed the changes in lung and lobe volume after lobectomy and predicted postoperative lung volume. The study found that lung volume decreased after lobectomy, but the attenuation distribution changed little. Machine learning models were used to predict postoperative lung volume, which can help with surgical planning and improve prognosis.
Lobectomy is an effective and well-established therapy for localized lung cancer. This study aimed to assess the lung and lobe change after lobectomy and predict the postoperative lung volume. The study included 135 lung cancer patients from two hospitals who underwent lobectomy (32, right upper lobectomy (RUL); 31, right middle lobectomy (RML); 24, right lower lobectomy (RLL); 26, left upper lobectomy (LUL); 22, left lower lobectomy (LLL)). We initially employ a convolutional neural network model (nnU-Net) for automatically segmenting pulmonary lobes. Subsequently, we assess the volume, effective lung volume (ELV), and attenuation distribution for each lobe as well as the entire lung, before and after lobectomy. Ultimately, we formulate a machine learning model, incorporating linear regression (LR) and multi-layer perceptron (MLP) methods, to predict the postoperative lung volume. Due to the physiological compensation, the decreased TLV is about 10.73%, 8.12%, 13.46%, 11.47%, and 12.03% for the RUL, RML, RLL, LUL, and LLL, respectively. The attenuation distribution in each lobe changed little for all types of lobectomy. LR and MLP models achieved a mean absolute percentage error of 9.8% and 14.2%, respectively. Radiological findings and a predictive model of postoperative lung volume might help plan the lobectomy and improve the prognosis.
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