期刊
MOLECULAR GENETICS AND GENOMICS
卷 291, 期 6, 页码 2225-2229出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00438-016-1243-7
关键词
m(6)A; Ring structure; Hydrogen bond; Chemical functionality; Support vector machine
资金
- Program for the Top Young Innovative Talents of Higher Learning Institutions of Hebei Province [BJ2014028]
- Outstanding Youth Foundation of North China University of Science and Technology [JP201502]
- China Postdoctoral Science Foundation [2015M582533]
- Scientific Research Foundation of the Education Department of Sichuan Province [2015JY0100]
- Fundamental Research Funds for the Central Universities, China [ZYGX2015J144, ZYGX2015Z006]
- Program for the Top Young Innovative Talents of Higher Learning Institutions of Hebei Province [BJ2014028]
- Outstanding Youth Foundation of North China University of Science and Technology [JP201502]
- China Postdoctoral Science Foundation [2015M582533]
- Scientific Research Foundation of the Education Department of Sichuan Province [2015JY0100]
- Fundamental Research Funds for the Central Universities, China [ZYGX2015J144, ZYGX2015Z006]
N (6)-Methyladenosine (m(6)A) plays important roles in many biological processes. The knowledge of the distribution of m(6)A is helpful for understanding its regulatory roles. Although the experimental methods have been proposed to detect m(6)A, the resolutions of these methods are still unsatisfying especially for Arabidopsis thaliana. Benefitting from the experimental data, in the current work, a support vector machine-based method was proposed to identify m(6)A sites in A. thaliana transcriptome. The proposed method was validated on a benchmark dataset using jackknife test and was also validated by identifying strain-specific m(6)A sites in A. thaliana. The obtained predictive results indicate that the proposed method is quite promising. For the convenience of experimental biologists, an online webserver for the proposed method was built, which is freely available at http://lin.uestc.edu.cn/server/M6ATH. These results indicate that the proposed method holds a potential to become an elegant tool in identifying m(6)A site in A. thaliana.
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