期刊
MATERIALS CHEMISTRY AND PHYSICS
卷 312, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.matchemphys.2023.128615
关键词
Electrochemical sensing; Covalent organic framework; Guanosine; Biomarkers; Carbon fiber paper
In this study, a facile and selective electrochemical sensor was developed for the sensing of guanosine. The sensor utilized a unique porous structure and ordered framework, enabling linear detection of guanosine concentration in the range of 0.123-720 μM under specific conditions.
Guanosine is an essential biomarker that enacts an important role in neuroprotection against brain-related activities, influences the metabolism of fatty acids, and assists in the improvement of the gastrointestinal tract. A facile and selective electrochemical sensor has been developed for the sensing of guanosine based on a hierarchical porous covalent organic framework. Owing to the distinctive 2D porous architecture and ordered framework of TpBD-COF, the irreversible electrooxidation of guanosine occurred at 1.03 V (vs. SCE) in phosphate buffer solution at pH 6. The anodic peak currents under optimal conditions were linear with guanosine concentration within the range of 0.123-720 mu M with a LOD of 40.63 nM under various optimal conditions. Moreover, the developed biosensor was used to determine guanosine in pharmaceutical tablets to confirm its potential application in the healthcare industry.
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