Composite films based on Bi2Se3 nanosheets and carbon nanotubes with photothermal and photodynamic functions for synergistic treatment

The use of functional nanomaterials to realize tumor therapeutic therapy has received considerable attention. However, a single type of nanomaterial usually can only achieve one specific function, and may cause biosafety problems due to poor metabolism. In this work, we have designed a kind of nanocomposite film based on Bi2Se3 nanosheets and carbon nanotubes, which can achieve efficient photothermal conversion and reactive oxygen species generation under near-infrared laser irradiation. Moreover, the developed films showed good biocompatibility in vivo. The multifunctional films showed remarkable therapeutic effects under 808 nm excitation with 0.3 W/cm(2) , which avoiding the introduction of nano-reagents into the mice and excessive laser power damage. Our work will provide reference for the use of nanomaterials with heterojunctions in synergistic therapy strategies of photothermal and photodynamic therapy.

Automated summary

A nanocomposite film based on Bi2Se3 nanosheets and carbon nanotubes has been designed in this study, which can efficiently convert light into heat and generate reactive oxygen species under near-infrared laser irradiation. The film also demonstrates good biocompatibility in vivo. The multifunctional film shows significant therapeutic effects, providing important reference for the synergistic therapy of photothermal and photodynamic therapy.