☆ 4.6 Article

Generation of Recombinant Snakehead Rhabdovirus (SHRV) Expressing Artificial MicroRNA Targeting Spring Viremia of Carp Virus (SVCV) P Gene and In Vivo Therapeutic Use Against SVCV Infection

MARINE BIOTECHNOLOGY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Pharmacology & Pharmacy

A new self-attenuated therapeutic influenza vaccine that uses host cell-restricted attenuation by artificial microRNAs

Ke Wen et al.

Summary: New strategies for developing vaccines and drugs against influenza viruses are urgently needed due to the continuous antigenic shift and drift and emergence of drug-resistant strains. In this study, the researchers designed and incorporated artificial microRNAs into the influenza viruses to target specific host genes involved in virus replication, resulting in reduced expression of these genes and increased protective efficacy of the engineered viruses as vaccines.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

添加到收藏夹

Review Genetics & Heredity

Emerging concepts of miRNA therapeutics: from cells to clinic

Caroline Diener et al.

Summary: In this review, the main challenges and strategies for the therapeutic application of miRNAs are discussed, with particular emphasis on approaches that have already been studied clinically.

TRENDS IN GENETICS (2022)

添加到收藏夹

Article Fisheries

Control of spring viremia of carp in common carp using RNA interference

Alamira Marzouk Fouad et al.

Summary: This study investigated the control of the Carp sprivivirus replication in cells and in common carp by targeting specific genes using RNA interference technology. The results showed that certain siRNAs effectively reduced the virus titer both in vitro and in vivo. In particular, the siRNA-M-271 + L-602 combination significantly reduced the mortality rate in common carp challenged with SVCV.

AQUACULTURE (2022)

添加到收藏夹

Review Cell Biology

Artificial miRNAs as therapeutic tools: Challenges and opportunities

Anna Kotowska-Zimmer et al.

Summary: RNA interference (RNAi) technology has been used for studying gene functions and therapeutic approaches, with amiRNAs showing the most complex structures. AmiRNAs can form mature siRNAs through two-step processing in cells, have dynamics similar to endogenous miRNAs, and are considered safer than other RNAi triggers.

WILEY INTERDISCIPLINARY REVIEWS-RNA (2021)

添加到收藏夹

Review Virology

Novirhabdoviruses versus fish innate immunity: A review

Mei He et al.

Summary: Novirhabdoviruses, pathogenic to bony fish, interact with fish innate immunity and may exploit microRNAs for immunosuppression, interfering with host antiviral defense mechanisms.

VIRUS RESEARCH (2021)

添加到收藏夹

Article Virology

Changes to virus taxonomy and to the International Code of Virus Classification and Nomenclature ratified by the International Committee on Taxonomy of Viruses (2021)

Peter J. Walker et al.

Summary: This article reports the changes to virus taxonomy approved and ratified by ICTV in March 2021. All proposals and revisions were passed by an absolute majority of ICTV members. ICTV mandated a new uniform rule for virus species naming, abolished the notion of a type species, and clarified its remit through an official definition of 'virus' and other types of mobile genetic elements.

ARCHIVES OF VIROLOGY (2021)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Generation of Self-Inhibitory Recombinant Viral Hemorrhagic Septicemia Virus (VHSV) by Insertion of Viral P Gene-Targeting Artificial MicroRNA into Viral Genome and Effect of Dicer Gene Knockout on the Recombinant VHSV Replication

Jun Soung Kwak et al.

Summary: The study showed that attenuating virus growth can be achieved by inserting specific amiR sequences into the viral genome, and enhancing replication of attenuated virus can be achieved by knocking out the Dicer gene in host cells. This suggests that regulating both viral and host cell genes can impact the virus infectivity.

MARINE BIOTECHNOLOGY (2021)

添加到收藏夹

Article Virology

Harnessing snakehead rhabdovirus (SHRV) for gene editing by installment of CRISPR/Cas9 in viral genome

Jun Soung Kwak et al.

Summary: The study evaluated the potential use of a piscine RNA virus SHRV as a delivery system for CRISPR/Cas9 in mammalian cells. It successfully knocked out the target gene of mammalian cells using IRF9 gene-targeting rSHRV, with the knockout efficiency possibly regulated by increasing temperature. Further optimization research is needed to enhance editing efficiency, but this study represents the first report on the possible applicability of a piscine RNA virus for gene editing in mammalian cells.

VIRUS RESEARCH (2021)

添加到收藏夹

Article Fisheries

Generation of microRNA-30e-producing recombinant viral hemorrhagic septicemia virus (VHSV) and its effect on in vitro immune responses

Jun Soung Kwak et al.

FISH & SHELLFISH IMMUNOLOGY (2019)

添加到收藏夹

Article Fisheries

Genetically engineered viral hemorrhagic septicemia virus (VHSV) vaccines

Min Sun Kim et al.

FISH & SHELLFISH IMMUNOLOGY (2019)

添加到收藏夹

Article Biochemical Research Methods

In-vitro inhibition of spring viremia of carp virus replication by RNA interference targeting the RNA-dependent RNA polymerase gene

Alamira Marzouk Fouad et al.

JOURNAL OF VIROLOGICAL METHODS (2019)

添加到收藏夹

Article Virology

MicroRNA-Based Attenuation of Influenza Virus across Susceptible Hosts

Barbara M. Waring et al.

JOURNAL OF VIROLOGY (2018)

添加到收藏夹

Review Mycology

Aphanomyces invadans, the causal agent of Epizootic Ulcerative Syndrome, is a global threat to wild and farmed fish

Nurul Aqilah Iberahim et al.

FUNGAL BIOLOGY REVIEWS (2018)

添加到收藏夹

Review Endocrinology & Metabolism

Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation

Jacob O'Brien et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

添加到收藏夹

Review Biotechnology & Applied Microbiology

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

Rajesha Rupaimoole et al.

NATURE REVIEWS DRUG DISCOVERY (2017)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Spring viraemia of carp virus: recent advances

Usama Ashraf et al.

JOURNAL OF GENERAL VIROLOGY (2016)

添加到收藏夹

Article Virology

The P Protein of Spring Viremia of Carp Virus Negatively Regulates the Fish Interferon Response by Inhibiting the Kinase Activity of TANK-Binding Kinase 1

Shun Li et al.

JOURNAL OF VIROLOGY (2016)

添加到收藏夹

Article Fisheries

Inhibition of spring viraemia of carp virus replication in an Epithelioma papulosum cyprini cell line by RNAi

M. Gotesman et al.

JOURNAL OF FISH DISEASES (2015)

添加到收藏夹

Article Virology

Inhibition of viral hemorrhagic septicemia virus replication using a short hairpin RNA targeting the G gene

Min Sun Kim et al.

ARCHIVES OF VIROLOGY (2011)

添加到收藏夹

Review Biochemistry & Molecular Biology

Posttranscriptional Regulation of MicroRNA Biogenesis in Animals

Haruhiko Siomi et al.

MOLECULAR CELL (2010)

添加到收藏夹

Article Pharmacology & Pharmacy

New tools to study RNA interference to fish viruses: Fish cell lines permanently expressing siRNAs targeting the viral polymerase of viral hemorrhagic septicemia virus

S. Ruiz et al.

ANTIVIRAL RESEARCH (2009)

添加到收藏夹

Review Cell Biology

Biogenesis of small RNAs in animals

V. Narry Kim et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)

添加到收藏夹

Review Genetics & Heredity

Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

Witold Filipowicz et al.

NATURE REVIEWS GENETICS (2008)

添加到收藏夹

Article Biochemistry & Molecular Biology

Human RISC couples microRNA biogenesis and posttranscriptional gene silencing

RI Gregory et al.

CELL (2005)

添加到收藏夹

Article Multidisciplinary Sciences

Modulation of hepatitis C virus RNA abundance by a liver-specific microRNA

CL Jopling et al.

SCIENCE (2005)

添加到收藏夹

Article Virology

Characterization of snakehead rhabdovirus infection in zebrafish (Danio rerio)

PE Phelan et al.

JOURNAL OF VIROLOGY (2005)

添加到收藏夹

Article Virology

The NV gene of Snakehead rhabdovirus (SHRV) is not required for pathogenesis, and a heterologous glycoprotein can be incorporated into the SHRV envelope

M Alonso et al.

JOURNAL OF VIROLOGY (2004)

添加到收藏夹

Review Fisheries

Spring viremia of carp (SVC)

W Ahne et al.

DISEASES OF AQUATIC ORGANISMS (2002)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.