INFRAFRONTIER: mouse model resources for modelling human diseases

Over the last decade, INFRAFRONTIER has positioned itself as a world-class Research Infrastructure for the generation, phenotyping, archiving, and distribution of mouse models in Europe. The INFRAFRONTIER network consists of 22 partners from 15 countries, and is continuously enhancing and broadening its portfolio of resources and services that are offered to the research community on a non-profit basis. By bringing together European rodent model expertise and providing valuable disease model services to the biomedical research community, INFRAFRONTIER strives to push the accessibility of cutting-edge human disease modelling technologies across the European research landscape. This article highlights the latest INFRAFRONTIER developments and informs the research community about its extensively utilised services, resources, and technical developments, specifically the intricacies of the INFRAFRONTIER database, use of Curated Disease Models, overview of the INFRAFRONTIER Cancer and Rare Disease resources, and information about its main state-of-the-art services.

Automated summary

INFRAFRONTIER has become a prominent research infrastructure in Europe for mouse model generation, phenotyping, archiving, and distribution. With a network of 22 partners from 15 countries, INFRAFRONTIER continuously expands its resources and services for the research community. By combining European rodent model expertise, INFRAFRONTIER aims to enhance accessibility of cutting-edge disease modelling technologies in Europe. The article provides an overview of INFRAFRONTIER's latest developments, its widely utilized services, resources, and technical advancements, including its database, Curated Disease Models, Cancer and Rare Disease resources, and state-of-the-art services.