期刊
MAGNETIC RESONANCE IN MEDICINE
卷 -, 期 -, 页码 -出版社
WILEY
DOI: 10.1002/mrm.29849
关键词
magnetic resonance imaging; oxygen; partial pressure; retinal vein occlusion; vitreous
The purpose of this study was to estimate vitreous oxygen concentration in ischemic eye disease by non-invasively performing MR T-1 mapping. The results showed that ischemic eye disease decreases vitreous T-1, potentially indicating an increase in vitreous partial pressure of oxygen (pO(2)) concentration. The study discusses potential theories for this unexpected result and highlights the potential clinical application of this technique in eye disease.
Purpose: To demonstrate MR T-1 mapping in vivo as a method to non-invasively estimate vitreous oxygen concentration in ischemic eye disease.Methods: Patients with ischemic eye disease (central retinal vein occlusion, ocular ischemic syndrome, and proliferative diabetic retinopathy) were prospectively recruited. MRI was performed on each patient before any treatment, with T-1 mapping acquired using an inversion recovery TrueFISP sequence at several inversion times, from a single slice positioned through the center of both eyes in the axial oblique plane. A phantom study measuring seven different concentrations of vitronectin, a protein released in ischemic eye disease, was undertaken to determine its potential confounding effect on T-1.Results: Ten participants were recruited (eight central retinal vein occlusion, one ocular ischemic syndrome, and one proliferative diabetic retinopathy). Of the eight central retinal vein occlusion cases, there was a statistically different vitreous T-1 in the diseased eye compared to the healthy control eye (4.306 vs. 4.518 s, p = 0.008). T-1 times did not significantly alter across the range of vitronectin concentrations.Conclusions: Ischemic eye disease decreases vitreous T-1, potentially implying an increase in vitreous partial pressure of oxygen (pO(2)) concentration given what is known from the relationship between 1/T-1 and pO(2). Potential theories for this unexpected result are discussed. This study provides further data on this technique, with potential clinical application in eye disease.
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