The effect of tube quality on externally calibrated quantitative nuclear magnetic resonance analysis: How bad can it be?

Article Chemistry, Analytical

Multinuclear NMR screening of pharmaceuticals using standardization by 2H integral of a deuterated solvent

Yulia B. Monakhova et al.

Summary: The paper discusses a new NMR standardization approach using the 2H integral of deuterated solvent for quantitative multinuclear analysis of pharmaceuticals. It extends the existing NMR procedure for the analysis of heparin products to determine Na+ and Cl- content in the matrix. Validation characteristics are evaluated, and the methodology provides an appealing alternative for NMR screening of inorganic and organic components in pharmaceutical products.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2022)

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Article Chemistry, Analytical

Novel approach of qNMR workflow by standardization using 2H integral: Application to any intrinsic calibration standard

Yulia B. Monakhova et al.

Summary: This paper introduces a new method for quantitative nuclear magnetic resonance (qNMR) analysis, using the NMR signal of another active nuclei for calibration. The new approach can be used to determine deuteration levels in different deuterated solvents, with benefits of reduced uncertainties and sample preparation steps.

TALANTA (2021)

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Article Chemistry, Analytical

Accurate and Precise External Calibration Enhances the Versatility of Quantitative NMR (qNMR)

Yuzo Nishizaki et al.

Summary: This study utilized the principle of reciprocity and certified reference materials to achieve accuracy and precision in external calibration qHNMR. By optimizing nutation experiments and carefully timing the tuning and matching process, the achieved accuracy of around 1.0% demonstrates the feasibility of EC-qHNMR as a highly practical research tool.

ANALYTICAL CHEMISTRY (2021)

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Article Chemistry, Multidisciplinary