4.7 Article

Nanoclay-Modified Hyaluronic Acid Microspheres for Bone Induction by Sustained rhBMP-2 Delivery

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Engineering, Biomedical

Laponite-Based Nanomaterials for Drug Delivery

Gita Kiaee et al.

Summary: Laponite is a clay-based material with highly ionic and large surface area, which allows for intercalation and dissolution of biomolecules for drug delivery. Its properties and architecture also enable the development of tunable pH-responsive drug delivery systems for sustained drug release.

ADVANCED HEALTHCARE MATERIALS (2022)

Article Engineering, Biomedical

Magnesium cationic cue enriched interfacial tissue microenvironment nurtures the osseointegration of gamma-irradiated allograft bone

Wenhao Wang et al.

Summary: Regardless of the advancement of synthetic bone substitutes, allograft-derived bone substitutes still dominate in the orthopaedic circle in the treatments of bone diseases. Nevertheless, the stringent devitalization process jeopardizes their osseointegration with host bone and therefore prone to long-term failure. Hence, improving osseointegration and transplantation efficiency remains important. The alteration of bone tissue microenvironment (TME) to facilitate osseointegration has been generally recognized.

BIOACTIVE MATERIALS (2022)

Article Engineering, Biomedical

Sustained release of BMP-2 using self-assembled layer-by-layer film-coated implants enhances bone regeneration over burst release

MayLin T. Howard et al.

Summary: This study investigated the design of different laponite clay diffusional barrier layer architectures in self-assembled LbL films to modulate the release kinetics of bone morphogenetic protein 2 (BMP-2) for bone regeneration. The results showed that sustained release of BMP-2 over 30 days significantly enhanced bone regeneration, while release over 2 days did not promote additional bone growth.

BIOMATERIALS (2022)

Article Biotechnology & Applied Microbiology

Biocompatible Nanocomposite Coatings Deposited via Layer-by-Layer Assembly for the Mechanical Reinforcement of Highly Porous Interconnected Tissue-Engineered Scaffolds

Aoife McFerran et al.

Summary: Tissue-engineered scaffolds, as an 'off-the-shelf' alternative to autograft procedures, can address the complications and limitations associated with autografts. In this study, nanocomposite coatings were successfully developed to improve the mechanical properties of open-cell structures without significantly affecting porosity, using poly(diallydimethylammonium chloride) (PDDA) and chitosan (CHI)-based polyelectrolyte systems as alternatives to poly(ethylenimine) (PEI)-based systems. The PDDA-based system showed equivalent physical and mechanical properties to the PEI-based system, but with significantly higher biocompatibility.

BIOENGINEERING-BASEL (2022)

Review Chemistry, Multidisciplinary

Controlled magnesium ion delivery system for in situ bone tissue engineering

Zuoying Yuan et al.

Summary: This article provides an overview of the biochemical mechanism of magnesium cation in inducing vascularized bone regeneration, and suggests optimizing the concentration of magnesium ions. It also summarizes various controlled magnesium delivery systems based on polymer-Mg composite scaffolds and Mg-containing hydrogels, discussing their design philosophy and parameters that regulate magnesium release. The importance of controlled delivery of magnesium ions in a dual-or multi-ions system, as well as the challenges and perspectives of magnesium-containing biomaterials for in situ bone tissue engineering, are highlighted.

JOURNAL OF CONTROLLED RELEASE (2022)

Article Chemistry, Multidisciplinary

Injectable Double Positively Charged Hydrogel Microspheres for Targeting-Penetration-Phagocytosis

Jiawei Lin et al.

Summary: This study presents a functional hydrogel microsphere designed for efficient drug delivery to joints. The microspheres exhibit targeting properties, cartilage penetration, and cellular phagocytosis, addressing the challenges of drug delivery in damaged tissues. The microspheres can be adsorbed onto the cartilage surface and release drugs over an extended period of time, effectively improving drug delivery efficiency and delaying the development of osteoarthritis.
Review Materials Science, Multidisciplinary

Nanoclays in medicine: a new frontier of an ancient medical practice

Kalpana S. Katti et al.

Summary: Clays have been used for medicinal purposes since 2500 BC due to their abundance in nature, biocompatibility, and versatility. Recent advances have expanded the use of clays in medicine, particularly in nanostructures and polymer clay nanocomposites. This review provides an overview of the structures and biomedical applications of common clays such as montmorillonite, LAPONITE (R), kaolinite, and halloysite. It discusses their uses in wound dressings, drug delivery, tissue engineering, as well as their impact on cellular processes and cell adhesion. The review also explores the mechanisms of clay-mediated bioactivity and emerging areas of use in osteogenesis and in vitro models of bone metastasis of cancer.

MATERIALS ADVANCES (2022)

Article Materials Science, Biomaterials

Controllable preparation of bioactive open porous microspheres for tissue engineering

Anqi Lin et al.

Summary: This study developed size-controllable microspheres with an open-porous structure, which were treated with alkalization to obtain a highly open pore structure and a large specific surface area. The microspheres showed potential as an ideal cell carrier to increase cell density and bioactivity.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

Article Engineering, Biomedical

Injectable hyaluronic acid and platelet lysate-derived granular hydrogels for biomedical applications

Barbara B. Mendes et al.

Summary: By combining NorHA and PL, PL-NorHA hybrid hydrogels were fabricated to support cell adhesion with tailorable physicochemical properties. Microgels of PL-NorHA produced using microfluidic techniques exhibited sustained protein release and enabled the fabrication of stable 3D printed structures.

ACTA BIOMATERIALIA (2021)

Article Biochemistry & Molecular Biology

Recent progress and challenges for polymeric microsphere compared to nanosphere drug release systems: Is there a real difference?

Mehran Alavi et al.

Summary: Polymeric microspheres and nanospheres have advantages as drug carriers, including simple preparation, controlled release rates, stimulus responsive delivery, improved physical properties, and stable scaffolds. These carriers have a significant impact on drug release rates.

BIOORGANIC & MEDICINAL CHEMISTRY (2021)

Review Materials Science, Biomaterials

Progress of gelatin-based microspheres (GMSs) as delivery vehicles of drug and cell

Zuoxiang Dong et al.

Summary: Gelatin-based microspheres (GMSs) have attractive features such as biocompatibility, biodegradability, and ease of manipulation. In recent years, they have been used as sustained delivery vehicles of drugs, cell carriers, and 3D scaffold components in tissue engineering, showing promising potentials.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

Article Toxicology

In vitro toxicity assessment of crosslinking agents used in hyaluronic acid dermal filler

Chang Hee Jeong et al.

Summary: The study found that BDDE led to higher cytotoxicity, affected cell viability and membrane integrity, increased ROS levels and MMP loss, and elevated inflammatory responses in cells, whereas PEGDE showed lower cytotoxicity, ROS production, and inflammatory responses. The data suggests that PEGDE is safer than BDDE as a crosslinker in HA dermal fillers.

TOXICOLOGY IN VITRO (2021)

Article Engineering, Biomedical

Bone regeneration in both small and large preclinical bone defect models using an injectable polymer-based substitute containing hydroxyapatite and reconstituted with saline or autologous blood

Delphine B. Maurel et al.

Summary: The study evaluated the bone formation after injection of microbeads reconstituted with saline buffer or autologous blood in two different preclinical models. Results showed similar mineralization process and bone formation in both groups, indicating that reconstitution with autologous blood did not enhance the regenerative capacity of the microbeads compared to saline buffer group.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2021)

Article Engineering, Biomedical

Hypoxia-mimicking 3D bioglass-nanoclay scaffolds promote endogenous bone regeneration

Xiao Zheng et al.

Summary: The study developed a novel scaffold combining biomaterials and a hypoxia mimicking agent, achieving improved mechanical properties and osteogenic differentiation of human adipose mesenchymal stem cells (ADSCs). In vitro and in vivo experiments demonstrated the scaffold's promotion of angiogenesis and bone regeneration.

BIOACTIVE MATERIALS (2021)

Article Engineering, Biomedical

Biomimetic injectable hydrogel microspheres with enhanced lubrication and controllable drug release for the treatment of osteoarthritis

Ying Han et al.

Summary: In this study, injectable hydrogel microspheres with enhanced lubrication and controllable drug release for OA treatment were developed by bioinspired by the super-lubrication property of cartilage and catecholamine chemistry of mussel. The tribological test and drug release test showed the enhanced lubrication and sustained drug release of the microspheres. Intra-articular injection of the functionalized microspheres into rat knee joint with an OA model provided significant therapeutic effect against the development of OA.

BIOACTIVE MATERIALS (2021)

Article Nanoscience & Nanotechnology

Development of Nanosilicate-Hydrogel Composites for Sustained Delivery of Charged Biopharmaceutics

Samuel T. Stealey et al.

Summary: In this study, a nanocomposite hydrogel composed of PEG and laponite was fabricated for sustained protein release, with slowed release attributed to the formation of NS-protein complexes. Experimental conditions, such as protein electrostatics, concentration, and incubation time, as well as the choice of buffer for initial suspension of NS particles, were found to significantly influence the release of bioactive proteins.

ACS APPLIED MATERIALS & INTERFACES (2021)

Article Materials Science, Biomaterials

The role of lithium in the osteogenic bioactivity of clay nanoparticles

Mohamed Mousa et al.

Summary: This study found that the bioactivity of LAPONITE (R) nanoparticles is not determined by their lithium content, but by other properties.

BIOMATERIALS SCIENCE (2021)

Review Biochemistry & Molecular Biology

The application of hyaluronic acid in bone regeneration

Peisong Zhai et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

Review Nanoscience & Nanotechnology

Hydrogel microparticles for biomedical applications

Andrew C. Daly et al.

NATURE REVIEWS MATERIALS (2020)

Article Biotechnology & Applied Microbiology

Effect of micropore/microsphere topography and a silicon-incorporating modified titanium plate surface on the adhesion and osteogenic differentiation of BMSCs

Wuchao Zhou et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2020)

Review Nanoscience & Nanotechnology

Materials design for bone-tissue engineering

Gerry L. Koons et al.

NATURE REVIEWS MATERIALS (2020)

Article Materials Science, Biomaterials

Enhancement of BMP-2 and VEGF carried by mineralized collagen for mandibular bone regeneration

Kun Liu et al.

REGENERATIVE BIOMATERIALS (2020)

Review Materials Science, Biomaterials

Attachment and detachment strategies in microcarrier-based cell culture technology: A comprehensive review

Sorour Derakhti et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

Review Biochemistry & Molecular Biology

The effect of hyaluronic acid hydrogels on dental pulp stem cells behavior

Elham Ahmadian et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

Review Pharmacology & Pharmacy

Applications of alginate microspheres in therapeutics delivery and cell culture: Past, present and future

Dinesh Dhamecha et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

Review Nanoscience & Nanotechnology

Laponite (R) : A key nanoplatform for biomedical applications?

Helena Tomas et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2018)

Article Multidisciplinary Sciences

Widespread changes in transcriptome profile of human mesenchymal stem cells induced by two-dimensional nanosilicates

James K. Carrow et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Nanoscience & Nanotechnology

Nanoclay Incorporated Polyethylene-Glycol Nanocomposite Hydrogels for Stimulating In Vitro and In Vivo Osteogenesis

Xinyun Zhai et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2018)

Article Chemistry, Multidisciplinary

Microstructure and Soft Glassy Dynamics of an Aqueous Laponite Dispersion

Khushboo Suman et al.

LANGMUIR (2018)

Review Engineering, Biomedical

Bone grafts and biomaterials substitutes for bone defect repair: A review

Wenhao Wang et al.

BIOACTIVE MATERIALS (2017)

Article Engineering, Biomedical

Bone induction at physiological doses of BMP through localization by clay nanoparticle gels

D. M. R. Gibbs et al.

BIOMATERIALS (2016)

Article Biophysics

An injectable, dual pH and oxidation-responsive supramolecular hydrogel for controlled dual drug delivery

Xinfeng Cheng et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2016)

Article Engineering, Chemical

Behaviour of laponite gels: Rheology, ageing, pH effect and phase state in the presence of dispersant

Pek-Ing Au et al.

CHEMICAL ENGINEERING RESEARCH & DESIGN (2015)

Article Dentistry, Oral Surgery & Medicine

Tissue engineering for bone regeneration and osseointegration in the oral cavity

Sophia P. Pilipchuk et al.

DENTAL MATERIALS (2015)

Review Engineering, Biomedical

Development of microspheres for biomedical applications: a review

Kazi M. Zakir Hossain et al.

PROGRESS IN BIOMATERIALS (2015)

Article Biochemistry & Molecular Biology

Aspect Ratio Dependent Cytotoxicity and Antimicrobial Properties of Nanoclay

Kamla Rawat et al.

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2014)

Article Chemistry, Multidisciplinary

Bioactive Silicate Nanoplatelets for Osteogenic Differentiation of Human Mesenchymal Stem Cells

Akhilesh K. Gaharwar et al.

ADVANCED MATERIALS (2013)

Article Chemistry, Multidisciplinary

Physicochemical Effects in Aging Aqueous Laponite Suspensions

A. Shahin et al.

LANGMUIR (2012)

Review Chemistry, Physical

Shear-thinning hydrogels for biomedical applications

Murat Guvendiren et al.

SOFT MATTER (2012)

Article Engineering, Biomedical

Mechanisms of magnesium-stimulated adhesion of osteoblastic cells to commonly used orthopaedic implants

H Zreiqat et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH (2002)