☆ 4.5 Article

Generation and engineering of potent single domain antibody-based bispecific IL-18 mimetics resistant to IL-18BP decoy receptor inhibition

MABS (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Biotechnology & Applied Microbiology

Emerging principles of cytokine pharmacology and therapeutics

Robert A. Saxton et al.

Summary: The use of cytokines for therapeutic purposes has been restricted due to their pleiotropic activity. However, recent insights from structural biology, protein engineering, and receptor pharmacology have provided strategies to overcome cytokine pleiotropy and develop improved cytokine-based therapeutics.

NATURE REVIEWS DRUG DISCOVERY (2023)

添加到收藏夹

Article Pharmacology & Pharmacy

Ozoralizumab: First Approval

Susan J. Keam

Summary: Ozoralizumab (Nanozora (R)), a trivalent anti-TNF alpha NANOBODY (R) compound, has gained approval in Japan for the treatment of inadequately managed rheumatoid arthritis. This article provides an overview of the development milestones leading to this approval, including its development by Taisho Pharmaceutical Co. Ltd.

DRUGS (2023)

添加到收藏夹

Review Immunology

The use of supercytokines, immunocytokines, engager cytokines, and other synthetic cytokines in immunotherapy

Xiaohu Zheng et al.

Summary: Cytokines play a critical role in immune regulation, but their clinical application is often limited by toxicity and lack of efficacy. Protein engineering and synthetic immunology provide new approaches to modify cytokine signaling and design engineered cytokines that selectively target specific cells.

CELLULAR & MOLECULAR IMMUNOLOGY (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

Envafolimab: First Approval

Anthony Markham

Summary: Envafolimab, a subcutaneously administered single domain anti-PD-L1 antibody, has recently been approved in China for the treatment of various solid tumors and chronic hepatitis B. It has better solubility and tissue penetration than full monoclonal antibodies, allowing for subcutaneous administration.

DRUGS (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Immunogenicity and humanization of single-domain antibodies

Martin A. Rossotti et al.

Summary: Single-domain antibodies have desirable properties as biologic drugs, but their sequences may increase immunogenicity risks. While most clinical trials show minimal immunogenicity, special caution is needed for highly potent sdAbs. Further research is needed to establish humanization thresholds to maximize human sequence content without compromising binding affinity or stability.

FEBS JOURNAL (2022)

添加到收藏夹

Review Oncology

Harnessing cytokines and chemokines for cancer therapy

David J. Propper et al.

Summary: Cytokines play a crucial role in cancer development and progression. While cytokines have been studied for their therapeutic potential in oncology, clinical trials have shown limited efficacy. However, the advent of immunotherapies and a better understanding of the tumor microenvironment have opened up new possibilities for harnessing cytokine networks in cancer treatment.

NATURE REVIEWS CLINICAL ONCOLOGY (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Antibody display technologies: selecting the cream of the crop

Bernhard Valldorf et al.

Summary: Antibody display technologies have enabled the successful isolation of antigen-specific antibodies with therapeutic potential, with genotype-phenotype coupling being a key feature. While phage display is the most established system, newer technologies like mammalian display have also matured in recent years.

BIOLOGICAL CHEMISTRY (2022)

添加到收藏夹

Review Pharmacology & Pharmacy

Engineering interferons and interleukins for cancer immunotherapy

Patrick G. Holder et al.

Summary: Cytokines are potent immunoregulatory proteins that play important roles in cancer and have the potential for cancer immunotherapy. However, the use of cytokines as therapeutics has been limited by their complex biology and toxicities. Recent advances in immune checkpoint inhibitors and combination immunotherapies have reinvigorated interest in cytokines as therapeutics.

ADVANCED DRUG DELIVERY REVIEWS (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Facile discovery of surrogate cytokine agonists

Michelle Yen et al.

Summary: This study presents a strategy to discover cytokine surrogate agonists by using modular ligands that exploit induced proximity and receptor dimer geometry as pharmacological metrics. The researchers generated combinatorial matrices of single-chain bispecific ligands and discovered that this approach can lead to the engineering of surrogate ligands that compel assembly of non-natural receptor heterodimers. The findings demonstrate the generalizability of this approach for the discovery of diversified agonists for various ligand-receptor systems.

CELL (2022)

添加到收藏夹

Article Chemistry, Medicinal

Biophysical Characterization and Stability of Modified IgG1 Antibodies with Different Hexamerization Propensities

Muriel D. van Kampen et al.

Summary: This study biophysically characterized the impact of self-association in IgG antibody variants, finding a correlation between increased self-association propensity and functional activity. The mutation E430G decreased conformational stability, but had no substantial effect on storage stability. These findings provide insights for the design and development of IgG-based therapeutics.

JOURNAL OF PHARMACEUTICAL SCIENCES (2022)

添加到收藏夹

News Item Biotechnology & Applied Microbiology

IL-2 upgrades show promise at ASCO

Elie Dolgin

Summary: Companies continue to pursue enhanced IL-2 candidates despite Nektar's setback.

NATURE BIOTECHNOLOGY (2022)

添加到收藏夹

Article Immunology

Multifunctional NK Cell-Engaging Antibodies Targeting EGFR and NKp30 Elicit Efficient Tumor Cell Killing and Proinflammatory Cytokine Release

Katja Klausz et al.

Summary: By generating novel NKCEs, it is possible to effectively induce NK cell-mediated tumor cell lysis and release proinflammatory cytokines, which may have significant implications for anti-tumor therapy.

JOURNAL OF IMMUNOLOGY (2022)

添加到收藏夹

Article Cell Biology

Antitumor immunity induced by antibody-based natural killer cell engager therapeutics armed with not-alpha IL-2 variant

Olivier Demaria et al.

Summary: This study presents the design of tetraspecific molecules that can activate natural killer cells for cancer therapy. The tetraspecific molecules selectively activate and proliferate natural killer cells, and the binding to tumor-associated antigens triggers cell cytotoxicity and cytokine production. In animal experiments, the tetraspecific molecules control tumor growth and accumulate at the tumor site. Furthermore, they can deplete circulating B cells without causing toxicity in non-human primates.

CELL REPORTS MEDICINE (2022)

添加到收藏夹

Article Immunology

Affinity Maturation of B7-H6 Translates into Enhanced NK Cell-Mediated Tumor Cell Lysis and Improved Proinflammatory Cytokine Release of Bispecific Immunoligands via NKp30 Engagement

Lukas Pekar et al.

Summary: Novel immunoligands targeting activating NK cell receptors were generated and showed enhanced killing of tumor cells by NK cells. Incorporating affinity-matured ligands for NK cell-activating receptors may represent an effective strategy for potent cancer immunotherapy agents.

JOURNAL OF IMMUNOLOGY (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Engineering Strategies for Immunomodulatory Cytokine Therapies: Challenges and Clinical Progress

Ivan S. Pires et al.

Summary: Cytokines play a significant role in therapy, but their pleiotropic action and local activity characteristics limit their administration through systemic routes. Various molecular and formulation engineering strategies are currently being applied to reduce treatment toxicity and maintain efficacy.

ADVANCED THERAPEUTICS (2021)

添加到收藏夹

Editorial Material Cell Biology

Cancer-killing, decoy-resistant interleukin-18

Kyohei Nakamura et al.

IMMUNOLOGY AND CELL BIOLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy

Ting Zhou et al.

NATURE (2020)

添加到收藏夹

Article Medicine, Research & Experimental

Biophysical and biochemical characterization of a VHH-based IgG-like bi- and trispecific antibody platform

Lukas Pekar et al.

MABS (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Interleukin-18 in Health and Disease

Koubun Yasuda et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

添加到收藏夹

Article Biochemical Research Methods

Antibody-cytokine fusion proteins: A novel class of biopharmaceuticals for the therapy of cancer and of chronic inflammation

Patrizia Murer et al.

NEW BIOTECHNOLOGY (2019)

添加到收藏夹

Review Oncology

Cytokines in clinical cancer immunotherapy

Pedro Berraondo et al.

BRITISH JOURNAL OF CANCER (2019)

添加到收藏夹

Review Immunology

Nanobody Engineering: Toward Next Generation Immunotherapies and Immunoimaging of Cancer

Timothee Chanier et al.

ANTIBODIES (2019)

添加到收藏夹

Article Oncology

A Dose-escalation Study of Recombinant Human Interleukin-18 in Combination With Ofatumumab After Autologous Peripheral Blood Stem Cell Transplantation for Lymphoma

Michael J. Robertson et al.

JOURNAL OF IMMUNOTHERAPY (2018)

添加到收藏夹

Article Pharmacology & Pharmacy

Caplacizumab: First Global Approval

Sean Duggan

DRUGS (2018)

添加到收藏夹

Article Oncology

Cergutuzumab amunaleukin (CEA-IL2v), a CEA- targeted IL-2 variant- based immunocytokine for combination cancer immunotherapy: Overcoming limitations of aldesleukin and conventional IL-2-based immunocytokines

Christian Klein et al.

ONCOIMMUNOLOGY (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Camelid and shark single domain antibodies: structural features and therapeutic potential

Doreen Koenning et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2017)

添加到收藏夹

Review Immunology

Immunocytokines for cancer treatment: past, present and future

Dario Neri et al.

CURRENT OPINION IN IMMUNOLOGY (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Novel human IgG1 and IgG4 Fc-engineered antibodies with completely abolished immune effector functions

Tilman Schlothauer et al.

PROTEIN ENGINEERING DESIGN & SELECTION (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface

Rob N. de Jong et al.

PLOS BIOLOGY (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands

Ignacio Moraga et al.

CELL (2015)

添加到收藏夹

Review Medicine, Research & Experimental

Structural insights and biomedical potential of IgNAR scaffolds from sharks

Stefan Zielonka et al.

MABS (2015)

添加到收藏夹

Review Biochemistry & Molecular Biology

Therapeutic antibody engineering by high efficiency cell screening

Achim Doerner et al.

FEBS LETTERS (2014)

添加到收藏夹

Review Oncology

Interleukin-2 in Renal Cell Carcinoma: A Has-Been or a Still-Viable Option?

Asim Amin et al.

JOURNAL OF KIDNEY CANCER AND VHL (2014)

添加到收藏夹

Article Oncology

A Dose-Escalation Study of Recombinant Human Interleukin-18 in Combination With Rituximab in Patients With Non-Hodgkin Lymphoma

Michael J. Robertson et al.

JOURNAL OF IMMUNOTHERAPY (2013)

添加到收藏夹

Article Oncology

Chemoimmunotherapy Using Pegylated Liposomal Doxorubicin and Interleukin-18 in Recurrent Ovarian Cancer: A Phase I Dose-Escalation Study

Fiona Simpkins et al.

CANCER IMMUNOLOGY RESEARCH (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

An improved yeast transformation method for the generation of very large human antibody libraries

Lorenzo Benatuil et al.

PROTEIN ENGINEERING DESIGN & SELECTION (2010)

添加到收藏夹

Article Biochemistry & Molecular Biology

SEEDbodies: fusion proteins based on strand-exchange engineered domain (SEED) CH3 heterodimers in an Fc analogue platform for asymmetric binders or immunofusions and bispecific antibodies

Jonathan H. Davis et al.

PROTEIN ENGINEERING DESIGN & SELECTION (2010)

添加到收藏夹

Article Oncology

A Phase 2, Randomized Study of SB-485232, rhIL-18, in Patients With Previously Untreated Metastatic Melanoma

Ahmad A. Tarhini et al.

CANCER (2009)

添加到收藏夹

Article Biochemistry & Molecular Biology

General Strategy to Humanize a Camelid Single-domain Antibody and Identification of a Universal Humanized Nanobody Scaffold

Cecile Vincke et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

添加到收藏夹

Review Oncology

Fc-based cytokines - Prospects for engineering superior therapeutics

Jalal A. Jazayeri et al.

BIODRUGS (2008)

添加到收藏夹

Article Oncology

A dose-escalation study of recombinant human interleukin-18 using two different schedules of administration in patients with cancer

Michael J. Robertson et al.

CLINICAL CANCER RESEARCH (2008)

添加到收藏夹

Article Oncology

Clinical and biological effects of recombinant human interleukin-18 administered by intravenous infusion to patients with advanced cancer

Michael J. Robertson et al.

CLINICAL CANCER RESEARCH (2006)

添加到收藏夹

Article Biochemical Research Methods

From rodent reagents to human therapeutics using antibody guided selection

J Osbourn et al.

METHODS (2005)

添加到收藏夹

Article Biochemistry & Molecular Biology

High-level and high-throughput recombinant protein production by transient transfection of suspension-growing human 293-EBNA1 cells

Y Durocher et al.

NUCLEIC ACIDS RESEARCH (2002)

添加到收藏夹

Article Oncology

Pegylated cytokines - Potential application in immunotherapy of cancer

JF Eliason

BIODRUGS (2001)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.