期刊
M S-MEDECINE SCIENCES
卷 39, 期 6-7, 页码 515-521出版社
EDP SCIENCES S A
DOI: 10.1051/medsci/2023083
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AML is a type of leukemia characterized by genetic abnormalities in myeloid precursor cells, impairing their maturation and function. Although intensive chemotherapy can achieve complete remission in 50% to 80% of AML patients, relapse is common. Despite the well-known role of calcium signaling in cancer, there is limited research on calcium targets in AML. This study aims to emphasize on calcium channels and associated signaling pathways in AML, with the aim of developing targeted treatments.
Acute myeloid leukemia (AML) is characterized by genetic aberrations in hematopoietic precursors of the myeloid lineage which lead to their defective maturation/function. While intensive chemotherapy protocols result in complete remission in 50 % to 80 % of AML patients, relapse occurs in the majority of cases. While calcium signalling is a well-known contributor to cancer hallmarks, few AML related studies have focused on relevant calcium targets. Our purpose here is to highlight calcium channels and associated signalling pathways involved in AML, in order to promote the development of treatments specifically targeting these pathways.
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