Management of alcoholic hepatitis: A clinical perspective

Article Gastroenterology & Hepatology

Increasing Prevalence and Racial Disparity of Alcohol-Related Gastrointestinal and Liver Disease During the COVID-19 Pandemic A Population-Based National Study

Sofi Damjanovska et al.

Summary: The COVID-19 pandemic has led to an increase in alcohol use disorders, which in turn is associated with a rise in alcohol-related gastrointestinal and liver diseases.

JOURNAL OF CLINICAL GASTROENTEROLOGY (2023)

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Review Gastroenterology & Hepatology

Therapeutic Pipeline in Alcohol-Associated Liver Disease

Nimish Thakral et al.

Summary: Alcohol-associated liver disease is a major cause of mortality and morbidity worldwide, and it is often diagnosed at an advanced stage. Corticosteroids, currently recommended as a first-line treatment for alcoholic hepatitis, have limited effectiveness. Early liver transplantation has shown consistent benefits in select patients, but its use remains inconsistent due to lack of standardized criteria.

SEMINARS IN LIVER DISEASE (2023)

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Article Gastroenterology & Hepatology

Safety, Pharmacokinetics, and Efficacy Signals of Larsucosterol (DUR-928) in Alcohol-Associated Hepatitis

Tarek Hassanein et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2023)

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Article Gastroenterology & Hepatology

Neutrophil extracellular traps contribute to liver damage and increase defective low-density neutrophils in alcohol- associated hepatitis

Yeonhee Cho et al.

Summary: In alcohol-associated hepatitis (AH), neutrophils contribute to liver damage through increased formation of neutrophil extracellular traps (NETs) and the presence of a unique population of low-density neutrophils (LDNs). LDNs exhibit a functionally exhausted phenotype, while high-density neutrophils (HDNs) are activated. Alcohol-induced NET release leads to the generation of LDNs from HDNs, which have decreased functionality and impaired clearance by macrophages. Depletion of both HDNs and LDNs prevents alcohol-induced NET production and liver damage in mice.

JOURNAL OF HEPATOLOGY (2023)

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Article Medicine, General & Internal

Effect of Prophylactic Antibiotics on Mortality in Severe Alcohol-Related Hepatitis A Randomized Clinical Trial

Alexandre Louvet et al.

Summary: This study aimed to determine the efficacy of amoxicillin-clavulanate compared with placebo on mortality in patients hospitalized with severe alcohol-related hepatitis and treated with prednisolone. The results showed that amoxicillin-clavulanate combined with prednisolone did not improve 2-month survival compared with prednisolone alone. Therefore, prophylactic antibiotics may not be beneficial for improving survival in patients hospitalized with severe alcohol-related hepatitis.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2023)

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Article Gastroenterology & Hepatology

Early liver transplantation for severe acute alcohol-related hepatitis after more than a decade of experience

Giacomo Germani et al.

Summary: In patients with severe acute alcohol-related hepatitis, liver transplantation is the only effective therapy, but there is still limited access to transplantation due to emphasis on pre-transplant abstinence and societal stigma. Therefore, there is a growing need for multicenter studies to improve selection practices and interventions for alcohol use disorder after transplantation.

JOURNAL OF HEPATOLOGY (2023)

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Article Gastroenterology & Hepatology

The role of neutrophils in alcohol-related hepatitis

Reenam S. Khan et al.

JOURNAL OF HEPATOLOGY (2023)

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Article Medicine, Research & Experimental

Design of a multicenter randomized clinical trial for treatment of Alcohol-Associated Hepatitis

Wanzhu Tu et al.

Summary: This study compared the survival benefits and safety profiles of anakinra plus zinc versus prednisone in patients with severe alcohol-associated hepatitis (AH). The results showed no significant difference in overall survival at 90 days between the patients treated with anakinra plus zinc and those treated with prednisone, and there were no significant differences in baseline characteristics between the two treatment groups.

CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS (2023)

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Article Surgery

Liver transplantation for severe alcoholic hepatitis: A multicenter Italian study

Giacomo Germani et al.

Summary: This study assessed the outcomes of early liver transplantation (eLT) in patients with severe alcoholic hepatitis (sAH) and found that eLT significantly improved survival in non-responders to medical therapy, when a strict selection process was applied.

AMERICAN JOURNAL OF TRANSPLANTATION (2022)

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Article Gastroenterology & Hepatology

Impact of the COVID-19 Pandemic on Hospitalizations for Alcoholic Hepatitis or Cirrhosis in Alberta, Canada

Abdel Aziz Shaheen et al.

Summary: This study evaluated the impact of COVID-19 restrictions on hospitalizations of patients with alcoholic and nonalcoholic cirrhosis as well as alcoholic hepatitis (AH) in Alberta, Canada. The study found that monthly admission rates for alcoholic and nonalcoholic cirrhosis remained stable before and during COVID-19, but there was a significant increase in admissions for alcoholic hepatitis.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2022)

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Review Gastroenterology & Hepatology

Management of alcohol use disorder in patients with cirrhosis in the setting of liver transplantation

Juan Pablo Arab et al.

Summary: This review discusses the management of alcohol use disorder in patients with alcohol-associated liver disease, particularly in the setting of liver transplantation. It emphasizes the importance of a multidisciplinary approach, including diagnosis, predictors of relapse, behavioral and pharmacological therapies. The review also proposes a comprehensive definition of relapse using contemporary biomarkers to guide future clinical trials for optimizing treatment, transplant selection, and post-transplant care of patients with AUD and cirrhosis.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2022)

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Article Gastroenterology & Hepatology

Long-term Outcomes of Stool Transplant in Alcohol-associated Hepatitis-Analysis of Clinical Outcomes, Relapse, Gut Microbiota and Comparisons with Standard Care

Cyriac A. Philips et al.

Summary: This study found that healthy donor fecal microbiota transplantation (FMT) is associated with significantly lower incidence of ascites, infections, encephalopathy, and alcohol relapse, as well as higher survival rates, in patients with severe alcohol-associated hepatitis (SAH) compared to standard of care (SoC). Furthermore, FMT was shown to have beneficial modulation of gut microbiota (GM).

JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY (2022)

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Review Gastroenterology & Hepatology

Review article: current and emerging therapies for acute alcohol-associated hepatitis

Puru Rattan et al.

Summary: Alcohol-associated hepatitis is a serious liver disease with high mortality. Current therapies, including corticosteroids, have limited efficacy. The understanding of the pathophysiology has led to the development of new therapies, and multidisciplinary approaches using digital health technologies are needed to tackle this increasing burden.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2022)

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Article Gastroenterology & Hepatology

IL-1 receptor antagonist plus pentoxifylline and zinc for severe alcohol-associated hepatitis

Gyongyi Szabo et al.

Summary: Combination therapy of anakinra, pentoxifylline, and zinc provides similar survival benefits compared to corticosteroid therapy in severe alcohol-associated hepatitis.

HEPATOLOGY (2022)

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Review Gastroenterology & Hepatology

Therapeutic advances in alcohol-associated hepatitis

Gyongyi Szabo et al.

Summary: In recent years, there has been significant progress in understanding alcohol-associated hepatitis (AH), accompanied by an increase in clinical trial activity. This review focuses on breakthroughs in AH understanding, which are leading to new paradigms for biomarker discovery, clinical trial activity, and patient care models. It suggests a future where multimodal data can be integrated to generate personalized biomarkers and therapies for patients with AH.

JOURNAL OF HEPATOLOGY (2022)

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Article Gastroenterology & Hepatology

Effect of rifaximin on infections, acute-on-chronic liver failure and mortality in alcoholic hepatitis: A pilot study (RIFA-AH)

Cesar Jimenez et al.

Summary: Rifaximin as an adjuvant treatment for alcoholic hepatitis can significantly reduce the number of infections and clinical complications, contributing to a lower incidence of acute-on-chronic liver failure and mortality.

LIVER INTERNATIONAL (2022)

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Article Gastroenterology & Hepatology

Early liver transplantation for severe alcohol-related hepatitis not responding to medical treatment: a prospective controlled study

Alexandre Louvet et al.

Lancet Gastroenterology & Hepatology (2022)

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Review Medicine, General & Internal

Alcohol-Associated Hepatitis

Ramon Bataller et al.

Summary: This article reviews the epidemiology, pathophysiology, and treatment of alcohol-associated hepatitis, including the evidence for glucocorticoids and liver transplantation.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Medicine, General & Internal

A phase II, multicenter, open-label, randomized trial of pegfilgrastim for patients with alcohol-associated hepatitis

John A. Tayek et al.

Summary: This trial aimed to evaluate the safety and efficacy of long-acting recombinant GCSF in patients with AH in the United States. The results showed that there was no significant survival benefit at 90 days in patients treated with pegfilgrastim+prednisolone compared to those treated with prednisolone alone. The incidence of complications and adverse events were similar between the two groups.

ECLINICALMEDICINE (2022)

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Review Surgery

Acute Alcohol-Associated Hepatitis in the COVID-19 Pandemic - a Structured Review

Philipp Schulz et al.

Summary: The COVID-19 pandemic has led to an increase in alcohol-related liver disease, particularly among women, young adults, African Americans, Hispanics, and patients living in rural areas. The number of AH admissions and candidates waiting for liver transplantation has also increased, emphasizing the need for improved healthcare services at both regional and individual levels.

CURRENT TRANSPLANTATION REPORTS (2022)

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Article Medicine, Research & Experimental

Distinct histopathological phenotypes of severe alcoholic hepatitis suggest different mechanisms driving liver injury and failure

Jing Ma et al.

Summary: Two distinct patterns of intrahepatic neutrophil infiltration are observed in severe alcoholic hepatitis (SAH) patients, suggesting separate mechanisms driving liver injury.

JOURNAL OF CLINICAL INVESTIGATION (2022)

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Article Gastroenterology & Hepatology

A Randomized Clinical Trial of Fecal Microbiota Transplant for Alcohol Use Disorder

Jasmohan S. Bajaj et al.

Summary: This study suggests that FMT may be a safe and effective treatment for patients with alcohol-related cirrhosis, reducing alcohol craving and consumption while improving cognition and quality of life.

HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

Neutrophils interact with cholangiocytes to cause cholestatic changes in alcoholic hepatitis

Masahiro Takeuchi et al.

Summary: In this study, researchers found that neutrophils in contact with bile ducts contribute to cholestasis in alcoholic hepatitis by binding to ITGB1 on cholangiocytes. The loss of ITPR3 in cholangiocytes co-cultured with neutrophils was observed, and AH neutrophils were found to be more potent than control neutrophils. This new understanding of the role of cholangiocytes in the pathogenesis of AH could lead to the identification of new therapeutic targets.

GUT (2021)

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Review Substance Abuse

Alcohol and other substance use during the COVID-19 pandemic: A systematic review

Amanda Roberts et al.

Summary: The systematic review found that alcohol and other substance use showed different trends during the Covid-19 pandemic. While there was an overall increase in alcohol consumption, the use of other substances also significantly increased. Mental health factors played a key role in the increased use of both alcohol and other substances.

DRUG AND ALCOHOL DEPENDENCE (2021)

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Article Gastroenterology & Hepatology

Development and prognostic relevance of a histologic grading and staging system for alcohol-related liver disease

Carolin Lackner et al.

Summary: The SALVE Histopathology Group developed and validated a grading and staging system for alcohol-related liver disease (ALD) and evaluated its prognostic utility in a multinational cohort of 445 patients. The system showed significant associations with disease activity and fibrosis stage, impacting both long-term and short-term outcomes in ALD patients.

JOURNAL OF HEPATOLOGY (2021)

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Article Medicine, Research & Experimental

IL-1 Signal Inhibition In Alcoholic Hepatitis (ISAIAH): a study protocol for a multicentre, randomised, placebo-controlled trial to explore the potential benefits of canakinumab in the treatment of alcoholic hepatitis

N. Vergis et al.

Summary: This study aims to explore the potential benefits of the IL-1 beta antibody, canakinumab, in treating alcoholic hepatitis (AH) by conducting a randomized trial with 58 participants to compare histological appearances and mortality rates before and after treatment.

TRIALS (2021)

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Article Gastroenterology & Hepatology

No Effect in Alcoholic Hepatitis of Gut-Selective, Broad-Spectrum Antibiotics on Bacterial Translocation or Hepatic and Systemic Inflammation

Sidsel Stoy et al.

Summary: In patients with alcoholic hepatitis, gut-targeted antibiotic treatment did not change markers of bacterial translocation and liver and systemic inflammation. The study suggests that bacterial translocation may be less important once the inflammatory process is established, or that reducing the gut bacteriome may be less important than altering its composition.

CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY (2021)

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Article Gastroenterology & Hepatology

PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis

Jonel Trebicka et al.

Summary: This study analyzed the precipitants leading to acute decompensation in cirrhosis patients, identifying proven bacterial infections and severe alcoholic hepatitis as the main causes. The number of precipitants was significantly associated with 90-day mortality, emphasizing the need for specific preventive and therapeutic strategies targeting these events.

JOURNAL OF HEPATOLOGY (2021)

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Review Medicine, General & Internal

Diagnosis and Treatment of Alcohol-Associated Liver Disease A Review

Ashwani K. Singal et al.

Summary: Alcohol-associated liver disease is a major cause of cirrhosis, with significant risk factors including amount and duration of alcohol consumption, gender, obesity, and specific genetic polymorphisms. Abstinence can greatly improve survival rates for patients with alcohol-associated liver disease.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Article Gastroenterology & Hepatology

Therapeutic HNF4A mRNA attenuates liver fibrosis in a preclinical model

Taihua Yang et al.

Summary: This study demonstrates the therapeutic utility of HNF4A mRNA delivery for liver fibrosis and cirrhosis in mouse models, showing restoration of hepatocyte functions and inhibition of fibrogenesis. The research reveals that HNF4A directly targets PON1, contributing to the attenuation of liver fibrosis through modulation of liver macrophages and hepatic stellate cells.

JOURNAL OF HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

Identification of optimal therapeutic window for steroid use in severe alcohol-associated hepatitis: A worldwide study

Juan Pablo Arab et al.

Summary: This international multi-center cohort study found that corticosteroid treatment only improved 30-day survival in patients with severe alcohol-associated hepatitis (AH), particularly those with MELD scores between 25 and 39. There was no survival benefit observed in patients with MELD scores over 51.

JOURNAL OF HEPATOLOGY (2021)

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Article Multidisciplinary Sciences

Super enhancer regulation of cytokine-induced chemokine production in alcoholic hepatitis

Mengfei Liu et al.

Summary: Alcoholic hepatitis is characterized by intense liver inflammation driven by excessive cytokines and chemokines production and immune cell infiltration. The study identified a super-enhancer that regulates the expression of multiple CXCL chemokines in alcoholic hepatitis and may be a potential therapeutic target.

NATURE COMMUNICATIONS (2021)

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Letter Medicine, General & Internal

Trends in Liver Transplantation for Acute Alcohol-Associated Hepatitis During the COVID-19 Pandemic in the US

Therese Bittermann et al.

JAMA NETWORK OPEN (2021)

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Article Gastroenterology & Hepatology

COVID-19 Aftershocks on Alcohol-Associated Liver Disease: An Early Cross-Sectional Report From the US Epicenter

Stephanie M. Rutledge et al.

Summary: The study confirmed the impact of the COVID-19 pandemic on the incidence of AUD and ALD, with a higher inpatient mortality rate among ALD patients, especially affecting minority populations. Additionally, early liver transplantation showed promising results in maintaining abstinence for AH patients during the COVID-19 pandemic.

HEPATOLOGY COMMUNICATIONS (2021)

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Review Gastroenterology & Hepatology

Gut dysbiosis as a driver in alcohol-induced liver injury

Bradley Fairfield et al.

Summary: Alcohol-related liver disease encompasses a spectrum of conditions, not all heavy drinkers develop severe forms, and the intestinal microbiome may play a role. This review explores the microbiome's role in different stages of alcohol-related liver disease, discussing its effects on disease pathogenesis.

JHEP REPORTS (2021)

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Article Gastroenterology & Hepatology

Diagnosis and Treatment of Alcohol-Associated Liver Diseases: 2019 Practice Guidance From the American Association for the Study of Liver Diseases

David W. Crabb et al.

HEPATOLOGY (2020)

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Review Gastroenterology & Hepatology

Assessment and Management of Infection in Alcoholic Hepatitis

Nikhil Vergis et al.

SEMINARS IN LIVER DISEASE (2020)

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Article Gastroenterology & Hepatology

Increasing Burden of Acute-On-Chronic Liver Failure Among Alcohol-Associated Liver Disease in the Young Population in the United States

Ashwani K. Singal et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2020)

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Article Gastroenterology & Hepatology

An Open-Label, Dose-Escalation Study to Assess the Safety and Efficacy of IL-22 Agonist F-652 in Patients With Alcohol-associated Hepatitis

Juan P. Arab et al.

HEPATOLOGY (2020)

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Article Gastroenterology & Hepatology

The Candida albicans exotoxin candidalysin promotes alcohol-associated liver disease

Huikuan Chu et al.

JOURNAL OF HEPATOLOGY (2020)

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Article Gastroenterology & Hepatology

Keratin 18 Is a Diagnostic and Prognostic Factor for Acute Alcoholic Hepatitis

Vatsalya Vatsalya et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2020)

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Article Gastroenterology & Hepatology

Recent advances in alcohol-related liver disease (ALD): summary of a Gut round table meeting

Matias A. Avila et al.

GUT (2020)

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Article Gastroenterology & Hepatology

The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017

Sadaf G. Sepanlou et al.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2020)

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Article Gastroenterology & Hepatology

In Severe Alcoholic Hepatitis, Serum Keratin-18 Fragments Are Diagnostic, Prognostic, and Theragnostic Biomarkers

Stephen R. Atkinson et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2020)

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Letter Medicine, General & Internal

Changes in Adult Alcohol Use and Consequences During the COVID-19 Pandemic in the US

Michael S. Pollard et al.

JAMA NETWORK OPEN (2020)

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Article Gastroenterology & Hepatology

Predictors of steroid non-response and new approaches in severe alcoholic hepatitis

Shiv Kumar Sarin et al.

CLINICAL AND MOLECULAR HEPATOLOGY (2020)

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Review Gastroenterology & Hepatology

Granulocyte colony-stimulating factor for alcoholic hepatitis: A systematic review and meta-analysis of randomised controlled trials

Astrid Marot et al.

JHEP REPORTS (2020)

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Article Gastroenterology & Hepatology

Effects of Endotoxin on Type 3 Inositol 1,4,5-Trisphosphate Receptor in Human Cholangiocytes

Andressa Franca et al.

HEPATOLOGY (2019)

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Article Gastroenterology & Hepatology

Pharmacological Inhibition of CCR2/5 Signaling Prevents and Reverses Alcohol-Induced Liver Damage, Steatosis, and Inflammation in Mice

Aditya Ambade et al.

HEPATOLOGY (2019)

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Review Gastroenterology & Hepatology

Ductular Reaction in Liver Diseases: Pathological Mechanisms and Translational Significances

Keisaku Sato et al.

HEPATOLOGY (2019)

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Review Gastroenterology & Hepatology

Endpoints and patient stratification in clinical trials for alcoholic hepatitis

Philippe Mathurin et al.

JOURNAL OF HEPATOLOGY (2019)

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Review Gastroenterology & Hepatology

Inflammatory pathways in alcoholic steatohepatitis

Bin Gao et al.

JOURNAL OF HEPATOLOGY (2019)

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Review Gastroenterology & Hepatology

Systematic review with meta-analysis: high mortality in patients with non-severe alcoholic hepatitis

Kris Bennett et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2019)

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Article Gastroenterology & Hepatology

Intestinal Fungal Dysbiosis and Systemic Immune Response to Fungi in Patients With Alcoholic Hepatitis

Sonja Lang et al.

HEPATOLOGY (2019)

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Article Multidisciplinary Sciences

Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis

Josepmaria Argemie et al.

NATURE COMMUNICATIONS (2019)

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Review Medicine, General & Internal

Alcohol use disorders

Andre F. Carvalho et al.

LANCET (2019)

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Article Multidisciplinary Sciences

Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease

Yi Duan et al.

NATURE (2019)

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Article Nutrition & Dietetics

ESPEN guideline on clinical nutrition in liver disease

Mathias Plauth et al.

CLINICAL NUTRITION (2019)

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Article Gastroenterology & Hepatology

Efficacy of Granulocyte Colony-stimulating Factor in the Management of Steroid-Nonresponsive Severe Alcoholic Hepatitis: A Double-Blind Randomized Controlled Trial

Saggere Muralikrishna Shasthry et al.

HEPATOLOGY (2019)

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Article Gastroenterology & Hepatology

Ductular Reaction Cells Display an Inflammatory Profile and Recruit Neutrophils in Alcoholic Hepatitis

Beatriz Aguilar-Bravo et al.

HEPATOLOGY (2019)

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Article Cell Biology

Digoxin Suppresses Pyruvate Kinase M2-Promoted HIF-1α Transactivation in Steatohepatitis

Xinshou Ouyang et al.

CELL METABOLISM (2018)

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Article Gastroenterology & Hepatology

Outcomes of Early Liver Transplantation for Patients With Severe Alcoholic Hepatitis

Brian P. Lee et al.

GASTROENTEROLOGY (2018)

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Article Gastroenterology & Hepatology

Corticosteroids Reduce Risk of Death Within 28 Days for Patients With Severe Alcoholic Hepatitis, Compared With Pentoxifylline or Placebo-a Meta-analysis of Individual Data From Controlled Trials

Alexandre Louvet et al.

GASTROENTEROLOGY (2018)

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Article Gastroenterology & Hepatology

Pyroptosis by caspase11/4-gasdermin-D pathway in alcoholic hepatitis in mice and patients

Elena Khanova et al.

HEPATOLOGY (2018)

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Editorial Material Gastroenterology & Hepatology

Exploring new treatment paradigms for alcoholic hepatitis by extrapolating from NASH and cholestasis

Thoetchai (Bee) Peeraphatdit et al.

JOURNAL OF HEPATOLOGY (2018)

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Article Gastroenterology & Hepatology

EASL Clinical Practice Guidelines: Management of alcohol-related liver disease

Mark Thursz et al.

JOURNAL OF HEPATOLOGY (2018)

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Article Medicine, General & Internal

Alcohol use and burden for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016

Max G. Griswold et al.

LANCET (2018)

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Article Medicine, General & Internal

Alcoholic liver disease

Helmut K. Seitz et al.

NATURE REVIEWS DISEASE PRIMERS (2018)

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Article Gastroenterology & Hepatology

Interaction Between the Patatin-Like Phospholipase Domain-Containing Protein 3 Genotype and Coffee Drinking and the Risk for Acute Alcoholic Hepatitis

Suthat Liangpunsakul et al.

HEPATOLOGY COMMUNICATIONS (2018)

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Article Gastroenterology & Hepatology

Dysregulation of serum bile acids and FGF19 in alcoholic hepatitis

Katharina Brandl et al.

JOURNAL OF HEPATOLOGY (2018)

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Article Gastroenterology & Hepatology

A Day-4 Lille Model Predicts Response to Corticosteroids and Mortality in Severe Alcoholic Hepatitis

Mauricio Garcia-Saenz-de-Sicilia et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2017)

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Article Gastroenterology & Hepatology

In Patients With Severe Alcoholic Hepatitis, Prednisolone Increases Susceptibility to Infection and Infection-Related Mortality, and Is Associated With High Circulating Levels of Bacterial DNA

Nikhil Vergis et al.

GASTROENTEROLOGY (2017)

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Article Gastroenterology & Hepatology

A Prospective Study of the Utility of Plasma Biomarkers to Diagnose Alcoholic Hepatitis

Julien Bissonnette et al.

HEPATOLOGY (2017)

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Article Gastroenterology & Hepatology

Caspase-Cleaved Keratin-18 Fragments Increase During Alcohol Withdrawal and Predict Liver-Related Death in Patients With Alcoholic Liver Disease

Sebastian Mueller et al.

HEPATOLOGY (2017)

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Article Gastroenterology & Hepatology

Interleukin-1 inhibition facilitates recovery from liver injury and promotes regeneration of hepatocytes in alcoholic hepatitis in mice

Arvin Iracheta-Vellve et al.

LIVER INTERNATIONAL (2017)

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Article Gastroenterology & Hepatology

Controversies in clinical trials for alcoholic hepatitis

Sarah R. Lieber et al.

JOURNAL OF HEPATOLOGY (2017)

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Review Immunology

Liver macrophages in tissue homeostasis and disease

Oliver Krenkel et al.

NATURE REVIEWS IMMUNOLOGY (2017)

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Letter Gastroenterology & Hepatology

Healthy Donor Fecal Microbiota Transplantation in Steroid-Ineligible Severe Alcoholic Hepatitis: A Pilot Study

Cyriac Abby Philips et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2017)

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Review Substance Abuse

A Mechanistic Review of Cell Death in Alcohol-Induced Liver Injury

Shaogui Wang et al.

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2016)

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Article Gastroenterology & Hepatology

Intensive Enteral Nutrition Is Ineffective for Patients With Severe Alcoholic Hepatitis Treated With Corticosteroids

Christophe Moreno et al.

GASTROENTEROLOGY (2016)

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Editorial Material Gastroenterology & Hepatology

Standard Definitions and Common Data Elements for Clinical Trials in Patients With Alcoholic Hepatitis: Recommendation From the NIAAA Alcoholic Hepatitis Consortia

David W. Crabb et al.

GASTROENTEROLOGY (2016)

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Article Gastroenterology & Hepatology

Combining Data From Liver Disease Scoring Systems Better Predicts Outcomes of Patients With Alcoholic Hepatitis

Alexandre Louvet et al.

GASTROENTEROLOGY (2015)

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Review Gastroenterology & Hepatology

Comparative Effectiveness of Pharmacological Interventions for Severe Alcoholic Hepatitis: A Systematic Review and Network Meta-analysis

Siddharth Singh et al.

GASTROENTEROLOGY (2015)

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Article Gastroenterology & Hepatology

Progenitor cell expansion and impaired hepatocyte regeneration in explanted livers from alcoholic hepatitis

Laurent Dubuquoy et al.

GUT (2015)

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Article Gastroenterology & Hepatology

The CLIF Consortium Acute Decompensation score (CLIF-C ADs) for prognosis of hospitalised cirrhotic patients without acute-on-chronic liver failure

Rajiv Jalan et al.

JOURNAL OF HEPATOLOGY (2015)

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Review Gastroenterology & Hepatology

Alcoholic liver disease: mechanisms of injury and targeted treatment

Alexandre Louvet et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2015)

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Article Medicine, General & Internal

Prednisolone or Pentoxifylline for Alcoholic Hepatitis

Mark R. Thursz et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

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Article Gastroenterology & Hepatology

Metadoxine improves the three- and six-month survival rates in patients with severe alcoholic hepatitis

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