期刊
LIPIDS IN HEALTH AND DISEASE
卷 22, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12944-023-01937-6
关键词
Mead acid; Eicosatrienoic acid; n-9; Arachidonic acid; Essential fatty acid; Polyunsaturated fatty acid
Mead acid is a polyunsaturated fatty acid that can be converted to specific lipid mediators and may have effects on inflammation, cancer, dermatitis, and cystic fibrosis. It plays a multifunctional role in various diseases.
Mead acid (MA, 5,8,11-eicosatrienoic acid) is an n-9 polyunsaturated fatty acid (PUFA) and a marker of essential fatty acid deficiency, but nonetheless generally draws little attention. MA is distributed in various normal tissues and can be converted to several specific lipid mediators by lipoxygenase and cyclooxygenase. Recent pathological and epidemiological studies on MA raise the possibility of its effects on inflammation, cancer, dermatitis and cystic fibrosis, suggesting it is an endogenous multifunctional PUFA. This review summarizes the biosynthesis, presence, metabolism and physiological roles of MA and its relation to various diseases, as well as the significance of MA in PUFA metabolism.
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