☆ 4.7 Letter

Infection risk associated with clonal hematopoiesis of indeterminate potential is partly mediated by hematologic cancer transformation in the UK Biobank

LEUKEMIA (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Hematology

A practical approach to curate clonal hematopoiesis of indeterminate potential in human genetic data sets

Caitlyn Vlasschaert et al.

Summary: Clonal hematopoiesis of indeterminate potential (CHIP) is a common age-related somatic mosaicism associated with significant morbidity and mortality. Differentiating true CHIP mutations from sequencing artifacts and germ line variants is a bioinformatic challenge. We present a stepwise method to improve the accuracy of CHIP calls using filtering, variant annotation, and population-based associations. This high-fidelity call set refines population-based associations of CHIP with incident outcomes and is crucial for clinical diagnostic assays.

BLOOD (2023)

添加到收藏夹

Letter Cardiac & Cardiovascular Systems

Interleukin-6 Receptor Polymorphism Attenuates Clonal Hematopoiesis-Mediated Coronary Artery Disease Risk Among 451 180 Individuals in the UK Biobank

Caitlyn Vlasschaert et al.

CIRCULATION (2023)

添加到收藏夹

Article Hematology

Association of clonal hematopoiesis with chronic obstructive pulmonary disease

Peter G. Miller et al.

Summary: Somatic mutations in blood cells are associated with the development and severity of chronic obstructive pulmonary disease (COPD), independent of age and smoking.

BLOOD (2022)

添加到收藏夹

Article Urology & Nephrology

Association of Clonal Hematopoiesis of Indeterminate Potential with Worse Kidney Function and Anemia in Two Cohorts of Patients with Advanced Chronic Kidney Disease

Caitlyn Vlasschaert et al.

Summary: This study found that genetic mutations in hematopoietic stem cells are associated with the progression of chronic kidney disease and anemia, and individuals with these mutations have a higher risk of kidney failure.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2022)

添加到收藏夹

Article Hematology

TET2-mutant clonal hematopoiesis and risk of gout

Mridul Agrawal et al.

Summary: Gout is a common inflammatory arthritis caused by hyperuricemia. This study found that CHIP, a condition related to hematologic cancers and cardiovascular disease, is associated with an increased risk of gout. Additionally, MSU crystals lead to elevated IL-1β levels in Tet2 knockout murine models.

BLOOD (2022)

添加到收藏夹

Letter Hematology

Clonal hematopoiesis of indeterminate potential and risk of death from COVID-19

Peter G. Miller et al.

BLOOD (2022)

添加到收藏夹

Article Immunology

Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis

Peter Geon Kim et al.

Summary: The study revealed an association between clonal hematopoiesis and osteoporosis, with inflammation induced by Dnmt3a mutations driving bone loss. This inflammation-mediated osteoporosis can be ameliorated by specific drugs.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Clonal hematopoiesis is associated with risk of severe Covid-19

Kelly L. Bolton et al.

Summary: Clonal hematopoiesis (CH) is associated with altered inflammatory profiles, increased risk of severe infections, particularly Covid-19, and other malignant diseases. Further investigation into the relationship between CH and severe infections may provide valuable insights for future research.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

HIV is associated with an increased risk of age-related clonal hematopoiesis among older adults

Nila J. Dharan et al.

Summary: People with HIV have a higher prevalence of clonal hematopoiesis (CH) compared to those without HIV, suggesting a selective advantage for CH emergence in the context of chronic infection and inflammation related to HIV infection. The most common mutated genes in this context were DNMT3A, TET2, and ASXL1. CH and HIV infection were independently associated with increases in blood parameters and biomarkers associated with inflammation.

NATURE MEDICINE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection

Seyedeh M. Zekavat et al.

Summary: Research shows that mosaic chromosomal alterations in blood-derived DNA are associated with an increased risk of various infections, such as sepsis and pneumonia. These alterations may serve as markers of impaired immunity, leading to an increased predisposition to infections.

NATURE MEDICINE (2021)

添加到收藏夹

Article Hematology

Causal Inference for Genetically Determined Levels of High-Density Lipoprotein Cholesterol and Risk of Infectious Disease

Mark Trinder et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2020)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

JAK2V617F-Mediated Clonal Hematopoiesis Accelerates Pathological Remodeling in Murine Heart Failure

Soichi Sano et al.

JACC-BASIC TO TRANSLATIONAL SCIENCE (2019)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Tet2-Mediated Clonal Hematopoiesis Accelerates Heart Failure Through a Mechanism Involving the IL-1β/NLRP3 Inflammasome

Soichi Sano et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2018)

添加到收藏夹

Article Medicine, General & Internal

Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease

S. Jaiswal et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

添加到收藏夹

Article Medicine, General & Internal

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

Siddhartha Jaiswal et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.