Impact of P-selectin-PSGL-1 Axis on Platelet-Endothelium-Leukocyte Interactions in Fatal COVID-19

Article Critical Care Medicine

Interleukin 6 and Its Correlation with COVID-19 in Terms of Outcomes in an Intensive Care Unit of a Rural Hospital: A Cross-sectional Study

Dhruv Talwar et al.

Summary: This study found that serum IL-6 is not a significant marker for clinical outcomes in ICU patients. However, IL-6 levels on admission may be correlated with CT severity scores and N:L ratio.

INDIAN JOURNAL OF CRITICAL CARE MEDICINE (2022)

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Article Cardiac & Cardiovascular Systems

SOLUBLE P-SELECTIN, PLATELET ACTIVITY AND RISK OF MORBIDITY AND MORTALITY IN COVID-19

Ramya Mosarla et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2022)

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Article Multidisciplinary Sciences

Effect of common maintenance drugs on the risk and severity of COVID-19 in elderly patients

Kin Wah Fung et al.

Summary: This study investigates the potential impact of maintenance drugs on COVID-19 susceptibility and severity. The results suggest that the use of ACE inhibitors, ARBs, statins, warfarin, direct factor Xa inhibitors, and P2Y12 inhibitors is associated with a reduced risk of acquiring and dying from COVID-19.

PLOS ONE (2022)

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Review Immunology

Dysfunctional State of T Cells or Exhaustion During Chronic Viral Infections and COVID-19: A Review

K. P. Mishra et al.

Summary: This review discusses the causes and effects of T cell dysfunction during chronic viral infection and COVID-19, and highlights new therapeutic potentials for treating chronic infections and other diseases.

VIRAL IMMUNOLOGY (2022)

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Article Health Care Sciences & Services

The association between statin and COVID-19 adverse outcomes: national COVID-19 cohort in South Korea

Ronald Chow et al.

Summary: This study used a nationwide healthcare claim database in South Korea to compare hospitalized COVID-19 patients who did and did not use statins prior to admission. The results showed that pre-hospitalization statin use was not significantly associated with increased risk of adverse outcomes and had a protective role in hypertensive patients.

ANNALS OF PALLIATIVE MEDICINE (2022)

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Article Health Care Sciences & Services

Cost-effectiveness analysis of statins for the treatment of hospitalized COVID-19 patients

Ronald Chow et al.

Summary: The cost-effectiveness analysis showed that treating hospitalized COVID-19 patients with statins was both cheaper and more effective than treatment without statins, indicating that statin-containing therapy should be further investigated and considered broadly for the treatment of hospitalized COVID-19 patients.

ANNALS OF PALLIATIVE MEDICINE (2022)

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Article Cardiac & Cardiovascular Systems

Effect of statin therapy on SARS-CoV-2 infection-related mortality in hospitalized patients

Lluis Masana et al.

Summary: This study suggests that patients admitted for COVID-19 who were treated with statins had a lower mortality rate compared to those not receiving statin therapy. Lower mortality rates were observed in patients who had been on statin therapy prior to hospitalization, indicating that statin therapy should not be discontinued due to the global concern of the pandemic or in patients hospitalized for COVID-19.

EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY (2022)

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Article Biochemistry & Molecular Biology

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

Rajendra Karki et al.

Summary: The combination of TNF-alpha and IFN-gamma induces inflammatory cell death characterized by PANoptosis, which can be inhibited to protect mice from the pathological effects and death caused by COVID-19. Blocking the cytokine-mediated inflammatory cell death signaling pathway may benefit patients with COVID-19 or other infectious and autoinflammatory diseases by limiting tissue damage/inflammation.

CELL (2021)

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Review Immunology

Statins as an adjunctive therapy for COVID-19: the biological and clinical plausibility

Tarek Kashour et al.

Summary: COVID-19, caused by SARS-CoV-2, poses a high risk for patients with underlying cardiovascular conditions and can lead to various cardiovascular complications. Statins have shown lipid-lowering and cardiovascular protective effects, as well as other beneficial properties, making them a potential candidate for treating COVID-19.

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2021)

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Review Virology

Immunity and inflammatory biomarkers in COVID-19: A systematic review

Ana Paula D. Iwamura et al.

Summary: COVID-19 is a clinical syndrome caused by SARS-CoV-2, with patients showing a range of symptoms from respiratory and gastrointestinal issues to potential multiple-organ failure. The severity of the disease is linked to the balance between antiviral and immune responses. An analysis of hospitalized patients indicated that lymphocyte counts are low in severe cases, while inflammatory markers like ESR, CRP, and IL-6 are elevated regardless of disease severity. Understanding these responses is crucial for effective treatment strategies.

REVIEWS IN MEDICAL VIROLOGY (2021)

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Article Genetics & Heredity

Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients

Anna C. Aschenbrenner et al.

Summary: This study provides novel insights into distinct molecular subgroups or phenotypes that are not simply explained by clinical parameters. Whole blood transcriptomes are shown to be extremely informative for COVID-19 as they capture the major drivers of disease severity, granulocytes.

GENOME MEDICINE (2021)

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Review Cardiac & Cardiovascular Systems

COVID-19: The Heart of the Matter-Pathological Changes and a Proposed Mechanism

Sharon E. Fox et al.

Summary: The SARS-CoV-2 virus has caused a significant impact worldwide, leading to over 88 million cases of COVID-19. The heart is commonly affected in COVID-19, with controversy surrounding the nature and extent of cardiac pathology. Patients infected with SARS-CoV-2 may sustain type 1 myocardial infarction without significant atherosclerotic coronary artery disease, while some present with unclear elevations in troponin enzymes.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS (2021)

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Review Physiology

Inhibitory Immune Checkpoint Molecules and Exhaustion of T cells in COVID-19

Martina Barnova et al.

Summary: COVID-19, caused by SARS-CoV-2, primarily affects the respiratory system and can lead to serious lung infections or pneumonia in severe cases. Clinical studies have shown that severe cases of SARS-CoV-2 infection can cause acute tissue damage due to a pathological immune response.

PHYSIOLOGICAL RESEARCH (2021)

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Review Pathology

The pulmonary pathology of COVID-19

Hans Bosmuller et al.

Summary: The lung is the primary organ affected by severe coronavirus disease 2019 (COVID-19) caused by the novel coronavirus SARS-CoV-2, with lung damage being the leading cause of death in most patients. Pathological features of fatal COVID-19 include early changes like edema, epithelial damage, and capillaritis/endothelialitis, progressing to exudative diffuse alveolar damage (DAD) in patients with respiratory insufficiency. These features are not specific to COVID-19 and can be found in other disorders, while clinically, early severe COVID-19 stages are characterized by high viral load, lymphopenia, pro-inflammatory cytokine secretion, and hypercoagulability.

VIRCHOWS ARCHIV (2021)

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Article Multidisciplinary Sciences

Association between antecedent statin use and decreased mortality in hospitalized patients with COVID-19

Aakriti Gupta et al.

Summary: The use of statins in patients hospitalized with COVID-19 is associated with a lower risk of inpatient mortality, potentially due to their anti-inflammatory and antithrombotic properties.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Massive image-based single-cell profiling reveals high levels of circulating platelet aggregates in patients with COVID-19

Masako Nishikawa et al.

Summary: The authors used massive single-cell image-based profiling to study circulating platelet aggregates in COVID-19 patients, revealing that nearly 90% of them had excessive platelet aggregates. The results also showed strong associations between the concentration of platelet aggregates and the severity, mortality, respiratory condition, and vascular endothelial dysfunction level of COVID-19 patients.

NATURE COMMUNICATIONS (2021)

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Article Hematology

A neutrophil activation signature predicts critical illness and mortality in COVID-19

Matthew L. Meizlish et al.

Summary: Pathologic immune hyperactivation, particularly neutrophil activation, plays a central role in severe COVID-19, with early markers predicting clinical decompensation and higher mortality rates. These findings highlight the importance of understanding immune responses in critically ill COVID-19 patients.

BLOOD ADVANCES (2021)

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Article Hematology

A PSGL-1 glycomimetic reduces thrombus burden without affecting hemostasis

Daniel J. Wong et al.

Summary: P-G6, a potent P-selectin inhibitor, blocks interactions between platelets and leukocytes in the process of venous thrombosis, reducing thrombus formation without affecting hemostasis.

BLOOD (2021)

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Review Pathology

The pathogenic role of epithelial and endothelial cells in early-phase COVID-19 pneumonia: victims and partners in crime

Marco Chilosi et al.

Summary: The understanding of the complex pathogenesis of COVID-19 interstitial pneumonia has been discussed in this article based on biopsies carried out in early/moderate phases and histology data obtained at postmortem analysis. The observations from autopsies cannot fully explain some clinical, radiological and physiopathological features observed in SARS-CoV-2 interstitial pneumonia, suggesting the need for further research to understand the discrepancies.

MODERN PATHOLOGY (2021)

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Article Multidisciplinary Sciences

COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets

Toni M. Delorey et al.

Summary: This study using single-cell and spatial atlases revealed the impact of COVID-19 infection on lung, kidney, liver, and heart tissues, showing structural remodeling and viral RNA enrichment. Differences in lung inflammatory responses and transcriptional alterations in heart tissue of COVID-19 patients were also identified, along with cell types and genes associated with disease severity.

NATURE (2021)

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Article Multidisciplinary Sciences

The spatial landscape of lung pathology during COVID-19 progression

Andre F. Rendeiro et al.

Summary: Recent studies using high-parameter imaging mass cytometry have provided insights into the cellular composition and spatial architecture of acute lung injury in humans, including injuries derived from SARS-CoV-2 infection. It was found that SARS-CoV-2 predominantly infects alveolar epithelial cells and induces a localized hyperinflammatory cell state associated with lung damage. As COVID-19 progresses, there is increased macrophage extravasation, along with increased numbers of mesenchymal cells and fibroblasts, possibly indicating attempts to repair the damaged lung tissue. The data generated help in developing a biologically interpretable landscape of lung pathology at both macroscopic and single-cell levels, providing a basis for understanding COVID-19 and lung pathology.

NATURE (2021)

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Review Oncology

Lung histopathological findings in COVID-19 disease - a systematic review

Giuseppe Pannone et al.

Summary: Histopathological characteristics of COVID-19 in lung tissue include features such as hyaline membranes, involvement of various cells, edema, hemorrhage, inflammatory response, and microthrombi. Fatal cases of COVID-19 present as a heterogeneous disease with different histological findings indicating various pathological pathways.

INFECTIOUS AGENTS AND CANCER (2021)

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Review Immunology

Neutrophils in COVID-19

Nico Reusch et al.

Summary: Research has found that the immune deviation of neutrophils in COVID-19 patients and promising therapeutic attempts to target them are crucial for understanding and treating the disease.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Biochemistry & Molecular Biology

The origins of SARS-CoV-2: A critical review

Edward C. Holmes et al.

Summary: This article critically reviews the current scientific evidence to help clarify the origin of SARS-CoV-2. Recent debate has centered around two competing ideas: a laboratory escape scenario and zoonotic emergence.

CELL (2021)

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Review Neurosciences

A role for T-cell exhaustion in Long COVID-19 and severe outcomes for several categories of COVID-19 patients

Kevin Roe

Summary: COVID-19 patients show differences in mortality rates and symptoms, potentially related to latent pathogen infections like Toxoplasma gondii. Patients with certain diseases and cancer comorbidities are more likely to experience severe outcomes.

JOURNAL OF NEUROSCIENCE RESEARCH (2021)

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Article Multidisciplinary Sciences

Relation of prior statin and anti-hypertensive use to severity of disease among patients hospitalized with COVID-19: Findings from the American Heart Association's COVID-19 Cardiovascular Disease Registry

Lori B. Daniels et al.

Summary: Research suggests that patients taking statins prior to hospitalization for COVID-19 have significantly lower odds of death, particularly among those with a history of cardiovascular disease and/or hypertension.

PLOS ONE (2021)

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Article Critical Care Medicine

Platelet activation in critically ill COVID-19 patients

Nader Yatim et al.

Summary: This study found that elevated soluble P-selectin levels at admission were associated with COVID-19 severity and could predict intubation and death. Gene expression analysis indicated that critically ill patients had increased expression of genes related to platelet activation, with specific genes showing grade-dependent upregulation. ROC curve analysis identified PPBP/CXCL7 and SELPLG as biomarkers for intubation.

ANNALS OF INTENSIVE CARE (2021)

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Article Immunology

Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19

Aldo Bonaventura et al.

Summary: The authors suggest that SARS-CoV-2 infection induces a prothrombotic state and dysregulated immunothrombosis, leading to severe manifestations of COVID-19. They also discuss potential antithrombotic and immunomodulating drugs for treating COVID-19 patients, aiming to reduce the acute and long-term consequences of the disease by targeting immunothrombosis.

NATURE REVIEWS IMMUNOLOGY (2021)

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Article Hematology

Prothrombotic changes in patients with COVID-19 are associated with disease severity and mortality

Fien A. von Meijenfeldt et al.

Summary: The study found that COVID-19 patients with higher levels of respiratory support have significantly increased in vivo activation of coagulation and fibrinolysis, despite receiving anticoagulant therapy. Blood markers such as fibrinogen, von Willebrand factor, etc., also change with increasing levels of respiratory support.

RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS (2021)

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Review Medicine, Research & Experimental

Immunopathogenesis and treatment of cytokine storm in COVID-19

Jae Seok Kim et al.

Summary: Severe COVID-19 is characterized by systemic hyper-inflammation and cytokine storm, often leading to acute respiratory distress syndrome and multiple organ failure. Treatment of COVID-19 cytokine storm is crucial, with anti-inflammatory therapies playing a significant role. Various approaches are being used, including new cytokine-targeted therapies, to address the cytokine storm associated with COVID-19.

THERANOSTICS (2021)

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Letter Immunology

Elevated exhaustion levels and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients

Hong-Yi Zheng et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

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Article Immunology

Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)

Bo Diao et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Hematology

Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome

Elizabeth A. Middleton et al.

BLOOD (2020)

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Article Hematology

Platelet gene expression and function in patients with COVID-19

Bhanu Kanth Manne et al.

BLOOD (2020)

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Article Hematology

Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study

George Goshua et al.

LANCET HAEMATOLOGY (2020)

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Article Cardiac & Cardiovascular Systems

Relation of Statin Use Prior to Admission to Severity and Recovery Among COVID-19 Inpatients

Lori B. Daniels et al.

AMERICAN JOURNAL OF CARDIOLOGY (2020)

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Article Hematology

Platelet activation and platelet-monocyte aggregate formation trigger tissue factor expression in patients with severe COVID-19

Eugenio D. Hottz et al.

BLOOD (2020)

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Review Pathology

A systematic review of pathological findings in COVID-19: a pathophysiological timeline and possible mechanisms of disease progression

Samuel B. Polak et al.

MODERN PATHOLOGY (2020)

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Article Pathology

Histiocytic hyperplasia with hemophagocytosis and acute alveolar damage in COVID-19 infection

Laura Prieto-Perez et al.

MODERN PATHOLOGY (2020)

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Article Pathology

The evolution of pulmonary pathology in fatal COVID-19 disease: an autopsy study with clinical correlation

Hans Boesmueller et al.

VIRCHOWS ARCHIV (2020)

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Review Hematology

The hypercoagulable state in COVID-19: Incidence, pathophysiology, and management

Mouhamed Yazan Abou-Ismail et al.

THROMBOSIS RESEARCH (2020)

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Review Cell Biology

COVID-19 and Neutrophils: The Relationship between Hyperinflammation and Neutrophil Extracellular Traps

Leandro Borges et al.

MEDIATORS OF INFLAMMATION (2020)

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Review Hematology

Neutrophil transendothelial migration: updates and new perspectives

Marie-Dominique Filippi

BLOOD (2019)

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Article Biochemistry & Molecular Biology

LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) distinctly regulate neutrophil extravasation through hotspots I and II

Young-Min Hyun et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2019)

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Article Multidisciplinary Sciences

Integrin CD11b activation drives anti-tumor innate immunity

Michael C. Schmid et al.

NATURE COMMUNICATIONS (2018)

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Review Immunology

Update on Neutrophil Function in Severe Inflammation

Esmaeil Mortaz et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Multidisciplinary Sciences

QuPath: Open source software for digital pathology image analysis

Peter Bankhead et al.

SCIENTIFIC REPORTS (2017)

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Review Hematology

P-selectin glycoprotein ligand-1 in T cells

Michael Abadier et al.

CURRENT OPINION IN HEMATOLOGY (2017)

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Article Immunology

PSGL-1 Is an Immune Checkpoint Regulator that Promotes T Cell Exhaustion

Roberto Tinoco et al.

IMMUNITY (2016)

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Article Hematology

P-selectin promotes neutrophil extracellular trap formation in mice

Julia Etulain et al.

BLOOD (2015)

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Review Immunology

Regulatory B Cells: Origin, Phenotype, and Function

Elizabeth C. Rosser et al.

IMMUNITY (2015)

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Article Medicine, Research & Experimental

Changes in regulatory B cells and their relationship with rheumatoid arthritis disease activity

Donghua Cui et al.

CLINICAL AND EXPERIMENTAL MEDICINE (2015)

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Review Immunology

Leukocyte Migration into Inflamed Tissues

Sussan Nourshargh et al.

IMMUNITY (2014)

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Article Immunology

IL-10-producing regulatory B cells induced by IL-33 (BregIL-33) effectively attenuate mucosal inflammatory responses in the gut

Susanne Sattler et al.

JOURNAL OF AUTOIMMUNITY (2014)

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Review Hematology

Platelets: bridging hemostasis, inflammation, and immunity

C. N. Jenne et al.

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY (2013)

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Review Immunology

Platelets and the immune continuum

John W. Semple et al.

NATURE REVIEWS IMMUNOLOGY (2011)

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Article Hematology

P-Selectin-Mediated Platelet-Neutrophil Aggregate Formation Activates Neutrophils in Mouse and Human Sickle Cell Disease

Renata Polanowska-Grabowska et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2010)

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Review Immunology

PSGL-1 function in immunity and steady state homeostasis

Douglas A. Carlow et al.

IMMUNOLOGICAL REVIEWS (2009)

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Review Immunology

Interstitial leukocyte migration and immune function

Peter Friedl et al.

NATURE IMMUNOLOGY (2008)

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Article Immunology

Functional role of p-selectin glycoprotein ligand 1/P-Selectin interaction in the generation of tolerogenic dendritic cells

Ana Urzainqui et al.

JOURNAL OF IMMUNOLOGY (2007)

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Article Immunology

Complete identification of E-selectin ligands on neutrophils reveals distinct functions of PSGL-1, ESL-1, and CD44

Andres Hidalgo et al.

IMMUNITY (2007)

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Article Hematology

Different effect of statins on platelet oxidized-LDL receptor (CD36 and LOX-1) expression in hypercholesterolemic subjects

F Bruni et al.

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS (2005)

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Article Multidisciplinary Sciences

Myeloperoxidase mediates neutrophil activation by association with CD11b/CD18 integrins

D Lau et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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Review Biochemistry & Molecular Biology

A new role in hemostasis for the adhesion receptor P-selectin

B Cambien et al.

TRENDS IN MOLECULAR MEDICINE (2004)

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Article Biochemistry & Molecular Biology

Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-κB activation in endothelial cells

I Kim et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

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Impact of P-selectin-PSGL-1 Axis on Platelet-Endothelium-Leukocyte Interactions in Fatal COVID-19

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