☆ 4.5 Review

Mesenchymal stem cell implantation provides short-term clinical improvement and satisfactory cartilage restoration in patients with knee osteoarthritis but the evidence is limited: a systematic review performed by the early-osteoarthritis group of ESSKA-European knee associates section

KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY (2023)

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Article Orthopedics

Analysis of the determinant factor of the medial joint space width after medial opening wedge high tibial osteotomy

Ho Won Jeong et al.

Summary: This study evaluated the factors affecting the medial joint space width (MJSW) after medial open wedge high tibial osteotomy (MOW-HTO). The change in MJSW was analyzed and correlated with parameters such as weight-bearing line ratio (WBLR), hip knee ankle angle (HKA), joint line convergence angle (JLCA), etc. The JLCA and WBLR were found to be major contributing factors to the change in MJSW, and cartilage status and clinical outcome were not related to MJSW.

ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY (2023)

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Article Orthopedics

Allogenic umbilical cord blood-derived mesenchymal stromal cell implantation was superior to bone marrow aspirate concentrate augmentation for cartilage regeneration despite similar clinical outcomes

Hong-Yeol Yang et al.

Summary: This study compared clinical and arthroscopic outcomes of BMAC and hUCB-MSC procedures in high tibial osteotomy for medial compartmental knee osteoarthritis. Both treatments showed significant improvement in clinical outcomes, but hUCB-MSC implantation was more effective in articular cartilage regeneration compared to BMAC augmentation.

KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY (2022)

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Article Orthopedics

Prognostic factors for medial open-wedge high tibial osteotomy with spacer implantation in patients with medial compartmental knee osteoarthritis

Fengkun Wang et al.

Summary: Spacer-type MOWHTO is an effective treatment for osteoarthritis with varus deformity. Age and K-L grade are prognostic factors for spacer-type MOWHTO.

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH (2022)

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Article Orthopedics

10-Year Survival Rates After High Tibial Osteotomy Using Angular Stable Internal Plate Fixation: Case Series With Subgroup Analysis of Outcomes After Combined Autologous Chondrocyte Implantation and High Tibial Osteotomy

Lisa Bode et al.

Summary: Good-to-excellent long-term results were observed after high tibial osteotomy (HTO) for medial compartment osteoarthritis (OA) or cartilage defects, especially in patients who underwent combined HTO and autologous cartilage implantation (ACI). HTO can delay or prevent the need for total knee arthroplasty (TKA) implantation, particularly in young, active patients with medial compartment damage.

ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE (2022)

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Review Orthopedics

Regenerative Potential of Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis and Chondral Defects: A Systematic Review and Meta-analysis

Bhargavi Maheshwer et al.

Summary: This study conducted a systematic review and meta-analysis on the effects of mesenchymal stem cells (MSCs) on cartilage regeneration, pain, and function. The results showed that MSC treatment significantly improved functional outcomes but did not have a significant impact on pain improvement. Furthermore, MSC treatment led to a significant increase in cartilage volume, but not in cartilage quality.

ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY (2021)

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Article Orthopedics

Subchondral bone or intra-articular injection of bone marrow concentrate mesenchymal stem cells in bilateral knee osteoarthritis: what better postpone knee arthroplasty at fifteen years? A randomized study

Philippe Hernigou et al.

Summary: A clinical trial involving 60 patients with bilateral knee osteoarthritis showed that implantation of MSCs in the subchondral bone was more effective in delaying TKA compared to injection into the joint. This study suggests that targeting the subchondral bone with MSCs may be a more beneficial treatment approach for knee osteoarthritis.

INTERNATIONAL ORTHOPAEDICS (2021)

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Review Rheumatology

Effect of Stem Cell Injections on Osteoarthritis-related Structural Outcomes: A Systematic Review

Jennifer Gong et al.

Summary: The systematic review of early-phase clinical trials showed consistent evidence of the beneficial effect of intraarticular MSC injections on articular cartilage and subchondral bone, but further research is needed due to modest sample sizes, methodological limitations, and potential publication bias.

JOURNAL OF RHEUMATOLOGY (2021)

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Article Orthopedics

Factors Influencing Clinical and MRI Outcomes of Mesenchymal Stem Cell Implantation With Concomitant High Tibial Osteotomy for Varus Knee Osteoarthritis

Yong Sang Kim et al.

Summary: The study aimed to investigate the outcomes of MSC implantation with concomitant HTO for varus knee OA. Results showed significant improvements in clinical and radiographic outcomes, with encouraging cartilage regeneration. Patient age and number of MSCs were found to be important factors influencing the outcomes.

ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE (2021)

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What is the clinically significant ideal mesenchymal stromal cell count in the management of osteoarthritis of the knee? – Meta-analysis of randomized controlled trials

Sathish Muthu et al.

Journal of Clinical Orthopaedics and Trauma (2021)

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Article Orthopedics

Implantation of mesenchymal stem cells in combination with allogenic cartilage improves cartilage regeneration and clinical outcomes in patients with concomitant high tibial osteotomy

Yong Sang Kim et al.

KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY (2020)

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Review Orthopedics

Mesenchymal stem cells in knee osteoarthritis treatment: A systematic review and meta-analysis

Yancheng Song et al.

JOURNAL OF ORTHOPAEDIC TRANSLATION (2020)

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Article Cell & Tissue Engineering

High tibial osteotomy with human umbilical cord blood-derived mesenchymal stem cells implantation for knee cartilage regeneration

Jun-Seob Song et al.

WORLD JOURNAL OF STEM CELLS (2020)

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Article Cell & Tissue Engineering

Original Implantation of allogenic umbilical cord blood-derived mesenchymal stem cells improves knee osteoarthritis outcomes: Two-year follow-up

Jun-Seob Song et al.

REGENERATIVE THERAPY (2020)

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Article Orthopedics

Mesenchymal Stem Cell Implantation in Knee Osteoarthritis: Midterm Outcomes and Survival Analysis in 467 Patients

Yong Sang Kim et al.

ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE (2020)

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Article Cell & Tissue Engineering

Adipose-derived mesenchymal stem cell therapy in the treatment of knee osteoarthritis: a randomized controlled trial

Julien Freitag et al.

REGENERATIVE MEDICINE (2019)

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Review Cell & Tissue Engineering

Application of mesenchymal stem cell therapy for the treatment of osteoarthritis of the knee: A concise review

Ai-Tong Wang et al.

WORLD JOURNAL OF STEM CELLS (2019)

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Article Orthopedics

Ten-Year Results of Medial Open-Wedge High Tibial Osteotomy and Chondral Resurfacing in Severe Medial Osteoarthritis and Varus Malalignment

Philipp Schuster et al.

AMERICAN JOURNAL OF SPORTS MEDICINE (2018)

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Article Orthopedics

Comparative Matched-Pair Analysis of Open-Wedge High Tibial Osteotomy With Versus Without an Injection of Adipose-Derived Mesenchymal Stem Cells for Varus Knee Osteoarthritis Clinical and Second-Look Arthroscopic Results

Yong Sang Kim et al.

AMERICAN JOURNAL OF SPORTS MEDICINE (2018)

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Article Cell & Tissue Engineering

Cartilage Regeneration in Osteoarthritic Patients by a Composite of Allogeneic Umbilical Cord Blood-Derived Mesenchymal Stem Cells and Hyaluronate hydrogel: Results from a Clinical Trial for Safety and Proof-of-Concept with 7 Years of Extended Follow-Up

Yong-Beom Park et al.

STEM CELLS TRANSLATIONAL MEDICINE (2017)

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Review Orthopedics

Analysis of Outcomes for High Tibial Osteotomies Performed With Cartilage Restoration Techniques

Cynthia A. Kahlenberg et al.

ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY (2017)

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Article Orthopedics

Load distribution in early osteoarthritis

Andreas H. Gomoll et al.

KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY (2016)

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Article Orthopedics

Assessment of clinical and MRI outcomes after mesenchymal stem cell implantation in patients with knee osteoarthritis: a prospective study

Y. S. Kim et al.

OSTEOARTHRITIS AND CARTILAGE (2016)

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Article Orthopedics

Comparative Matched-Pair Analysis of the Injection Versus Implantation of Mesenchymal Stem Cells for Knee Osteoarthritis

Yong Sang Kim et al.

AMERICAN JOURNAL OF SPORTS MEDICINE (2015)

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Review Orthopedics

Mesenchymal stem cells for the management of inflammation in osteoarthritis: state of the art and perspectives

Y. -M. Pers et al.

OSTEOARTHRITIS AND CARTILAGE (2015)

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Article Orthopedics

Medial Opening Wedge High Tibial Osteotomy for Medial Compartment Overload/Arthritis in the Varus Knee Prognostic Factors

Davide Edoardo Bonasia et al.

AMERICAN JOURNAL OF SPORTS MEDICINE (2014)

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Review Orthopedics

Survival and clinical outcome of isolated high tibial osteotomy and combined biological knee reconstruction

Joshua D. Harris et al.

KNEE (2013)

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Review Rheumatology

Mesenchymal stem cells in joint disease and repair

Frank Barry et al.

NATURE REVIEWS RHEUMATOLOGY (2013)

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Article Orthopedics

Inflammatory stimuli differentially modulate the transcription of paracrine signaling molecules of equine bone marrow multipotent mesenchymal stromal cells

R. Vezina Audette et al.

OSTEOARTHRITIS AND CARTILAGE (2013)

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Article Cell & Tissue Engineering

Thrombospondin-2 secreted by human umbilical cord blood-derived mesenchymal stem cells promotes chondrogenic differentiation

Sang Young Jeong et al.

STEM CELLS (2013)

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Article Orthopedics

Intra-articular injection of human mesenchymal stem cells (MSCs) promote rat meniscal regeneration by being activated to express Indian hedgehog that enhances expression of type II collagen

M. Horie et al.

OSTEOARTHRITIS AND CARTILAGE (2012)

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Article Cell & Tissue Engineering

Trophic Effects of Mesenchymal Stem Cells in Chondrocyte Co-Cultures are Independent of Culture Conditions and Cell Sources

Ling Wu et al.

TISSUE ENGINEERING PART A (2012)

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Review Medicine, General & Internal

The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration

Alessandro Liberati et al.

BMJ-BRITISH MEDICAL JOURNAL (2009)

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Review Rheumatology

Technology Insight:: adult mesenchymal stem cells for osteoarthritis therapy

Ulrich Noeth et al.

NATURE CLINICAL PRACTICE RHEUMATOLOGY (2008)

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Letter Orthopedics

Untitled

MJ Rossi et al.

AMERICAN JOURNAL OF SPORTS MEDICINE (2002)

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