4.7 Review

Beneficial Effect of Societal Factors on APOE-ε2 and ε4 Carriers' Brain Health: A Systematic Review

出版社

OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glad237

关键词

Apolipoprotein E4; Cognitive impairment; Cognitive reserve; Health disparity; Minority and vulnerable populations

向作者/读者索取更多资源

Societal factors can reduce the harmful impact of APOE-epsilon 4 and enhance the beneficial impact of APOE-epsilon 2 on cognitive outcomes.
Background Apolipoprotein-E (APOE) epsilon 4 and epsilon 2 are the most prevalent risk-increasing and risk-reducing genetic predictors of Alzheimer's disease, respectively. However, the extent to which societal factors can reduce the harmful impact of APOE-epsilon 4 and enhance the beneficial impact of APOE-epsilon 2 on brain health has not yet been examined systematically.Methods To fill this gap, we conducted a systematic review searching for studies in MEDLINE, Embase, PsycINFO, and Scopus until June 2023, that included: (a) 1 of 5 social determinants of health (SDH) identified by Healthy People 2030, (b) APOE-epsilon 2 or APOE-epsilon 4 allele carriers, (c) cognitive or brain-biomarker outcomes, and (d) studies with an analysis of how APOE-epsilon 2 and/ or APOE-epsilon 4 carriers differ on outcomes when exposed to SDH.Results From 14 076 articles retrieved, 124 met the inclusion criteria. In most of the studies, exposure to favorable SDH reduced APOE-epsilon 4's detrimental effect and enhanced APOE-epsilon 2's beneficial effect on cognitive and brain-biomarker outcomes (cognition: 70.5%, n: 74/105; brain-biomarkers: 71.4%, n: 20/28). A similar pattern of results emerged in each of the 5 Healthy People 2030 SDH categories, where finishing high school, having resources to satisfy basic needs, less air pollution, less negative external stimuli that can generate stress (eg, negative age stereotypes), and exposure to multiple favorable SDH were associated with better cognitive and brain health among APOE-epsilon 4 and APOE-epsilon 2 carriers.Conclusions Societal factors can reduce the harmful impact of APOE-epsilon 4 and enhance the beneficial impact of APOE-epsilon 2 on cognitive outcomes. This suggests that plans to reduce dementia should include community-level policies promoting favorable SDH.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据