期刊
MOLECULAR CELL
卷 64, 期 5, 页码 982-992出版社
CELL PRESS
DOI: 10.1016/j.molcel.2016.10.025
关键词
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资金
- NIH [F30 DK108494, GM059789-15/P250VA, DK108259, DK101573]
- Clinical and Translational Science Award program through the NIH National Center for Advancing Translational Sciences [UL1TR000427, KL2TR000428]
Histone-modifying enzymes regulate transcription and are sensitive to availability of endogenous small-molecule metabolites, allowing chromatin to respond to changes in environment. The gut microbiota produces a myriad of metabolites that affect host physiology and susceptibility to disease; however, the underlying molecular events remain largely unknown. Here we demonstrate that microbial colonization regulates global histone acetylation and methylation in multiple host tissues in a diet-dependent manner: consumption of a Western-type diet prevents many of the microbiota-dependent chromatin changes that occur in a polysaccharide-rich diet. Finally, we demonstrate that supplementation of germ-free mice with short-chain fatty acids, major products of gut bacterial fermentation, is sufficient to recapitulate chromatin modification states and transcriptional responses associated with colonization. These findings have profound implications for understanding the complex functional interactions between diet, gut microbiota, and host health.
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