期刊
MOLECULAR CELL
卷 62, 期 2, 页码 169-180出版社
CELL PRESS
DOI: 10.1016/j.molcel.2016.03.014
关键词
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资金
- Fondation pour la Recherche Medicale (FRM) analyse bio-informatique pour la recherche en biologie program as well as the ANR Episperm3 program [ANR-15-CE12-0005-02]
- INCa [2013-082]
- World Wide Cancer Research foundation [16-0280]
- Marie Curie Initial Training Network - European Commission (FP7-PEOPLE-ITN) [PITN-GA-289880]
- Fondation ARC
- above-mentioned FRM grant
- NIH [GM105933, DK107868, GM115961]
- NIH
- Starr Foundation Tri-Institutional Stem Cell Initiative [2014-034]
- Agence Nationale de la Recherche (ANR) [ANR-15-CE12-0005] Funding Source: Agence Nationale de la Recherche (ANR)
Recently discovered histone lysine acylation marks increase the functional diversity of nucleosomes well beyond acetylation. Here, we focus on histone butyrylation in the context of sperm cell differentiation. Specifically, we investigate the butyrylation of histone H4 lysine 5 and 8 at gene promoters where acetylation guides the binding of Brdt, a bromodomain-containing protein, thereby mediating stagespecific gene expression programs and post-meiotic chromatin reorganization. Genome-wide mapping data show that highly active Brdt-bound gene promoters systematically harbor competing histone acetylation and butyrylation marks at H4 K5 and H4 K8. Despite acting as a direct stimulator of transcription, histone butyrylation competes with acetylation, especially at H4 K5, to prevent Brdt binding. Additionally, H4 K5K8 butyrylation also marks retarded histone removal during late spermatogenesis. Hence, alternating H4 acetylation and butyrylation, while sustaining direct gene activation and dynamic bromodomain binding, could impact the final male epigenome features.
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