期刊
MOLECULAR CELL
卷 63, 期 4, 页码 547-552出版社
CELL PRESS
DOI: 10.1016/j.molcel.2016.06.038
关键词
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资金
- NIGMS NIH HHS [R35 GM118068] Funding Source: Medline
Modifications of histones play important roles in balancing transcriptional output. The discovery of acyl marks, besides histone acetylation, has added to the functional diversity of histone modifications. Since all modifications use metabolic intermediates as substrates for chromatin-modifying enzymes, the prevalent landscape of histone modifications in any cell type is a snapshot of its metabolic status. Here, we review some of the current findings of how differential use of histone acylations regulates gene expression as response to metabolic changes and differentiation programs.
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