期刊
MOLECULAR CELL
卷 64, 期 1, 页码 65-78出版社
CELL PRESS
DOI: 10.1016/j.molcel.2016.08.019
关键词
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资金
- European Research Council [ERC-2013-StG-336427]
- French National Research Agency [ANR-12-JSV6-0002-01, LabEx ANR-11-LABX-0071, ANR-11-IDEX-0005-01, ANR-10-INSB-04]
- EDF Radiobiology program [RB 2014-01]
- Fondation ARC
- Ligue Nationale contre le Cancer (Equipe labellisee)
- European Commission Network of Excellence EpiGeneSys [HEALTH-F4-2010-257082]
- VIRUCEPTION [ANR-13-BSV3-0001-01]
- LabEx DEVweCAN [ANR-10-LABX-61]
- University Pierre et Marie Curie
- La Ligue contre le Cancer
- University Paris Diderot
- [ERC-2009-AdG_20090506]
- [ANR-11-LABX-0044_DEEP]
- [ANR-10-IDEX-0001-02 PSL*]
Chromatin integrity is critical for cell function and identity but is challenged by DNA damage. To understand how chromatin architecture and the information that it conveys are preserved or altered following genotoxic stress, we established a system for real-time tracking of parental histones, which characterize the pre-damage chromatin state. Focusing on histone H3 dynamics after local UVC irradiation in human cells, we demonstrate that parental histones rapidly redistribute around damaged regions by a dual mechanism combining chromatin opening and histone mobilization on chromatin. Importantly, parental histones almost entirely recover and mix with new histones in repairing chromatin. Our data further define a close coordination of parental histone dynamics with DNA repair progression through the damage sensor DDB2 (DNA damage-binding protein 2). We speculate that this mechanism may contribute to maintaining a memory of the original chromatin landscape and may help preserve epigenome stability in response to DNA damage.
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