期刊
JOURNAL OF VIRAL HEPATITIS
卷 30, 期 10, 页码 830-833出版社
WILEY
DOI: 10.1111/jvh.13875
关键词
care organization; hepatitis C; hospital; mental health; psychiatry; public health
This study conducted a retrospective analysis of HCV serology results in a psychiatric hospital in France, aiming to explore the characteristics of seropositive patients with and without a positive viral load. The findings revealed that among the HCV-positive patients, a subgroup had no active HCV infection. These individuals without identified risk factors for HCV are more likely to be PWMDs yet to be treated for HCV, highlighting the importance of systematic screening in this population in the context of HCV elimination.
Hepatitis C virus (HCV) is highly prevalent in people with mental disorders (PWMDs). However, in the international context of HCV elimination, no previous study has explored the features of seropositive PWMDs with vs. without a positive viral load (VL). We retrospectively retrieved all HCV serology results of patients hospitalized in 2019, 2020 and 2021 in the second-largest psychiatric hospital of France. Using the medical records of all patients found seropositive for HCV, the following data were collected: sex (male, female), age (in years), previous history of illicit drug use except cannabis (yes or no) and previous history of incarceration (yes or no). We conducted a case-control comparison of these variables between the PWMDs who had and did not have a positive VL, thus providing odds ratios and 95% confidence intervals (ORs [95% CI]). In a total of 13,276 inpatients, 2540 (19.1%) underwent at least one HCV serology; 55 of them (2.16%) were found positive. A VL count was performed for 48 of them, finding 15 (31.3%) individuals with active HCV. Compared with those with a negative VL, these 15 individuals were less likely to have previous documented illicit drug use (OR = 0.18; 95% CI [0.05-0.68]) and to have been previously incarcerated (OR = 0.23; 95% CI [0.06-0.99]); age and sex did not statistically differ. In the context of HCV elimination, PWMDs yet to be treated for HCV are more likely to be those with no identified risk factor for HCV, which supports a strategy of systematic screening for HCV among PWMDs.
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