4.7 Article

Inhibiting NLRP3 inflammasome signaling pathway promotes neurological recovery following hypoxic-ischemic brain damage by increasing p97-mediated surface GluA1-containing AMPA receptors

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Oxidative Stress Underlies the Ischemia/Reperfusion-Induced Internalization and Degradation of AMPA Receptors

Lindsay M. Achzet et al.

Summary: Stroke is the fifth leading cause of death in the United States, where ischemic stroke can lead to occlusion of blood vessels supplying the brain, particularly affecting the hippocampus. Oxidative stress signaling cascade may mediate the internalization and degradation of AMPAR subunits following ischemia/reperfusion, indicating its potential vital role in cell death processes.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biochemistry & Molecular Biology

Aagab acts as a novel regulator of NEDD4-1-mediated Pten nuclear translocation to promote neurological recovery following hypoxic-ischemic brain damage

Chunfang Dai et al.

Summary: The study suggests that Aagab may serve as a regulator of NEDD4-1-mediated Pten nuclear translocation to promote functional recovery following HIBD in neonatal rats, providing a new potential therapeutic target for guiding clinical treatment for HIE.

CELL DEATH AND DIFFERENTIATION (2021)

Review Obstetrics & Gynecology

Emerging therapies and management for neonatal encephalopathy-controversies and current approaches

Ryan M. McAdams et al.

Summary: Neonatal encephalopathy has a significant impact on newborn survival and neurodevelopmental outcomes, with therapeutic hypothermia being the established standard treatment. Despite therapeutic hypothermia, a proportion of infants still suffer long-term disabilities from brain injury. Innovative therapies may offer the possibility of further improving neurodevelopmental outcomes.

JOURNAL OF PERINATOLOGY (2021)

Review Neurosciences

Excitotoxicity Revisited: Mitochondria on the Verge of a Nervous Breakdown

Nicoletta Plotegher et al.

Summary: Excitotoxicity occurs in pathological scenarios where mitochondrial function is compromised, affecting neuronal responses to glutamate. Research needs to focus on glutamate toxicity in specific disease models and re-evaluate the impact of mitochondrial dysfunction on excitotoxicity to identify new therapeutic targets.

TRENDS IN NEUROSCIENCES (2021)

Article Cell Biology

Neferine Protects against Hypoxic-Ischemic Brain Damage in Neonatal Rats by Suppressing NLRP3-Mediated Inflammasome Activation

Jin-Jin Zhu et al.

Summary: The study demonstrated the neuroprotective effect of neferine on hypoxic-ischemic encephalopathy (HIE) by inhibiting neuronal pyroptosis, thereby ameliorating neurological inflammation and oxidative stress. Neferine may offer a promising treatment strategy for HIE by targeting pyroptosis-related mechanisms.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Review Cell Biology

The cell biology of synapse formation

Thomas C. Sudhof

Summary: Synapses achieve their plasticity and specificity through the collaborative action of synaptic adhesion molecules (SAMs), which play a crucial role in assembling synapses and signal transduction.

JOURNAL OF CELL BIOLOGY (2021)

Article Multidisciplinary Sciences

p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression

Yuan Ge et al.

NATURE COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

Anti-inflammatory effect of afatinib (an EGFR-TKI) on OGD-induced neuroinflammation

Yen-Ju Chen et al.

SCIENTIFIC REPORTS (2019)

Review Biology

The NLRP3 inflammasome: a new player in neurological diseases

Elif Eren et al.

TURKISH JOURNAL OF BIOLOGY (2019)

Article Radiology, Nuclear Medicine & Medical Imaging

Incidence and pattern of brain lesions in paediatric septic shock patients

Debora Sanz et al.

BRITISH JOURNAL OF RADIOLOGY (2018)

Article Cell & Tissue Engineering

Inflammatory Responses are Sex Specific in Chronic Hypoxic-Ischemic Encephalopathy

Abdullah Al Mamun et al.

CELL TRANSPLANTATION (2018)

Review Biochemistry & Molecular Biology

VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling

Johannes van den Boom et al.

MOLECULAR CELL (2018)

Article Multidisciplinary Sciences

Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis

Brienne A. McKenzie et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Neurosciences

SPARC and GluA1-Containing AMPA Receptors Promote Neuronal Health Following CNS Injury

Emma V. Jones et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2018)

Review Neurosciences

AMPA Receptor Trafficking in Natural and Pathological Aging

Sandra Jurado

FRONTIERS IN MOLECULAR NEUROSCIENCE (2018)

Review Neurosciences

The AMPA Receptor Code of Synaptic Plasticity

Graham H. Diering et al.

NEURON (2018)

Review Clinical Neurology

Neonatal hypoxic ischemic encephalopathy: an update on disease pathogenesis and treatment

Edibe Pembegul Yildiz et al.

EXPERT REVIEW OF NEUROTHERAPEUTICS (2017)

Review Neurosciences

Inflammasomes, Hormesis, and Antioxidants in Neuroinflammation: Role of NRLP3 in Alzheimer Disease

Manuela Pennisi et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2017)

Review Clinical Neurology

Neonatal hypoxic ischemic encephalopathy: an update on disease pathogenesis and treatment

Edibe Pembegul Yildiz et al.

EXPERT REVIEW OF NEUROTHERAPEUTICS (2017)

Article Neurosciences

Animal models of hypoxic-ischemic encephalopathy: optimal choices for the best outcomes

Lan Huang et al.

REVIEWS IN THE NEUROSCIENCES (2017)

Review Neurosciences

NLRP3 Inflammasome in Neurological Diseases, from Functions to Therapies

Limin Song et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2017)

Review Neurosciences

Synaptic AMPA receptor composition in development, plasticity and disease

Jeremy M. Henley et al.

NATURE REVIEWS NEUROSCIENCE (2016)

Review Immunology

Recent Advances of the NLRP3 Inflammasome in Central Nervous System Disorders

Keren Zhou et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2016)

Article Multidisciplinary Sciences

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Jianjin Shi et al.

NATURE (2015)

Review Pediatrics

Hypoxic-Ischemic Encephalopathy A Review for the Clinician

Martha Douglas-Escobar et al.

JAMA PEDIATRICS (2015)

Article Medicine, Research & Experimental

Long-term potentiation decay and memory loss are mediated by AMPAR endocytosis

Zhifang Dong et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Biochemistry & Molecular Biology

Nedd8 Regulates Inflammasome-Dependent Caspase-1 Activation

Jesus A. Segovia et al.

MOLECULAR AND CELLULAR BIOLOGY (2015)

Review Neurosciences

The mechanisms and treatment of asphyxial encephalopathy

Guido Wassink et al.

FRONTIERS IN NEUROSCIENCE (2014)

Review Chemistry, Multidisciplinary

Inflammatory responses in hypoxic ischemic encephalopathy

Fudong Liu et al.

ACTA PHARMACOLOGICA SINICA (2013)

Editorial Material Neurosciences

Glutamate receptor-dependent synaptic plasticity

Bruno G. Frenguelli

NEUROPHARMACOLOGY (2013)

Review Medicine, Research & Experimental

Calcium-permeable AMPA receptors in neonatal hypoxic-ischemic encephalopathy (Review)

Xiao-Juan Tang et al.

BIOMEDICAL REPORTS (2013)

Article Medicine, General & Internal

Childhood Outcomes after Hypothermia for Neonatal Encephalopathy

Seetha Shankaran et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Article Clinical Neurology

Predicting motor outcome and death in term hypoxic-ischemic encephalopathy

M. Martinez-Biarge et al.

NEUROLOGY (2011)

Article Obstetrics & Gynecology

Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy

Jennifer J. Kurinczuk et al.

EARLY HUMAN DEVELOPMENT (2010)

Review Pharmacology & Pharmacy

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

Stephen F. Traynelis et al.

PHARMACOLOGICAL REVIEWS (2010)

Review Pathology

NOD-Like Receptors: Role in Innate Immunity and Inflammatory Disease

Grace Chen et al.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2009)

Article Medicine, Research & Experimental

Innate instruction of adaptive immunity revisited: the inflammasome

Stephanie C. Eisenbarth et al.

EMBO MOLECULAR MEDICINE (2009)

Article Biochemistry & Molecular Biology

PICK1-mediated Glutamate Receptor Subunit 2 (GluR2) Trafficking Contributes to Cell Death in Oxygen/Glucose-deprived Hippocampal Neurons

Rebecca M. Dixon et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Clinical Neurology

Is cerebral palsy preventable?

Karin B. Nelson et al.

CURRENT OPINION IN NEUROLOGY (2008)

Article Cell Biology

AAA ATPase p97/VCP: cellular functions, disease and therapeutic potential

Neeraj Vij

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2008)

Article Endocrinology & Metabolism

Secondary energy failure after cerebral hypoxia-ischemia in the immature rat

RC Vannucci et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2004)

Review Clinical Neurology

Long-term developmental outcome of asphyxiated term neonates

ME Dilenge et al.

JOURNAL OF CHILD NEUROLOGY (2001)