Arginine methylation of HSPA8 by PRMT9 inhibits ferroptosis to accelerate hepatitis B virus-associated hepatocellular carcinoma progression

Article Oncology

HBx-Induced HSPA8 Stimulates HBV Replication and Suppresses Ferroptosis to Support Liver Cancer Progression

Yufei Wang et al.

Summary: HBV-induced upregulation of HSPA8 promotes hepatocarcinogenesis by suppressing ferroptosis and stimulating HBV replication, identifying HSPA8 as a potential therapeutic target in liver cancer.

CANCER RESEARCH (2023)

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Article Neurosciences

Mechanism of SOX10 in ferroptosis of hippocampal neurons after intracerebral hemorrhage via the miR-29a-3p/ACSL4 axis

Hui Chen et al.

Summary: This study investigated the role of SOX10 in ferroptosis of hippocampal neurons after intracerebral hemorrhage (ICH). The findings suggest that SOX10 overexpression improves cell viability, decreases reactive oxygen species and Fe2+ levels, and increases gluta-thione and glutathione peroxidase 4 levels in ICH models. Additionally, SOX10 increases miR-29a-3p expression, which limits ACSL4 transcription and promotes ferroptosis of hippocampal neurons after ICH.

JOURNAL OF NEUROPHYSIOLOGY (2023)

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Article Biochemistry & Molecular Biology

Long noncoding RNA MAGI2-AS3 regulates the H2O2 level and cell senescence via HSPA8

Yingmin Zhang et al.

Summary: The downregulation of MAGI2-AS3 decreases superoxide levels and hydrogen peroxide content by stabilizing the HSPA8 protein level, leading to delayed cell senescence through the suppression of the ROS/MAP2K6/p38 signaling pathway. These findings suggest a potential anti-aging application.

REDOX BIOLOGY (2022)

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Article Gastroenterology & Hepatology

Inhibition of HSPA8 by rifampicin contributes to ferroptosis via enhancing autophagy

Juan Zhou et al.

Summary: This study reveals the potential molecular mechanisms for ferroptosis in rifampicin-induced liver injury. It is found that rifampicin activates high-throughput autophagy, leading to the degradation of ferritin and the increase of free iron. The study also highlights the important roles of HSPA8 and autophagy in the hepatotoxicity of rifampicin. Inducing HSPA8 or inhibiting autophagy and ferroptosis can alleviate the hepatotoxicity of rifampicin.

LIVER INTERNATIONAL (2022)

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Article Multidisciplinary Sciences

The protein arginine methyltransferase PRMT9 attenuates MAVS activation through arginine methylation

Xuemei Bai et al.

Summary: This study discovered that PRMT9 directly targets MAVS and methylates it, inhibiting the aggregation and autoactivation of MAVS. This provides an explanation for the regulatory mechanism of MAVS in maintaining innate immune homeostasis.

NATURE COMMUNICATIONS (2022)

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Article Nanoscience & Nanotechnology

Intravesical Mucoadhesive Hydrogel Induces Chemoresistant Bladder Cancer Ferroptosis through Delivering Iron Oxide Nanoparticles in a Three-Tier Strategy

Ao Qi et al.

Summary: This study introduced a three-tier delivery strategy utilizing a mucoadhesive hydrogel platform to convey hyaluronic acid-coated iron oxide nanoparticles (IONP-HA), effectively inhibiting chemoresistant bladder cancer and inducing ferroptosis through endocytosis. The strategy successfully delivered the IONPs stepwise from anatomical to cellular levels, increasing iron content up to 50-fold compared to systemic administration, presenting a potential regimen for chemoresistant bladder cancer.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Review Cell Biology

Ferroptosis: molecular mechanisms and health implications

Daolin Tang et al.

Summary: Cell death can be executed through different subroutines, such as ferroptosis which is an iron-dependent form of non-apoptotic cell death. Ferroptosis can occur through two major pathways, driven by redox imbalance and abnormal expression of redox-active enzymes. The process is precisely regulated at multiple levels, with the transcription factor NFE2L2 playing a central role in anti-ferroptotic defense.

CELL RESEARCH (2021)

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Article Multidisciplinary Sciences

A targetable LIFR-NF-κB-LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis

Fan Yao et al.

Summary: The loss of LIFR promotes liver tumorigenesis and resistance to drug-induced ferroptosis by upregulating iron-sequestering cytokine LCN2 through NF-kappa B signaling. Targeting LCN2 with a neutralizing antibody may enhance ferroptosis induction and anticancer effects in liver cancer therapy.

NATURE COMMUNICATIONS (2021)

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Review Biochemistry & Molecular Biology

CD44: A Multifunctional Mediator of Cancer Progression

Malak Hassn Mesrati et al.

Summary: CD44, a non-kinase cell surface transmembrane glycoprotein, is widely implicated as a cancer stem cell marker in multiple cancers. Cells overexpressing CD44 possess CSC traits and resistance to therapy. The CD44 gene undergoes alternative splicing, resulting in different isoforms that interact with various ligands and drive cancer-associated signaling pathways. However, the association between CD44 expression levels and clinicopathological features is contradictory, although high CD44 expression significantly contributes to tumorigenic mechanisms.

BIOMOLECULES (2021)

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Article Biochemistry & Molecular Biology

Arginine and lysine methylation of MRPS23 promotes breast cancer metastasis through regulating OXPHOS

Lingxia Liu et al.

Summary: This study uncovered a unique mechanism of controlling OXPHOS through arginine and lysine methylation, and highlighted the impact of the PRMT7-SETD6-MRPS23 axis during breast cancer metastasis.

ONCOGENE (2021)

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Article Biochemistry & Molecular Biology

The CD44/COL17A1 pathway promotes the formation of multilayered, transformed epithelia

Kei Kozawa et al.

Summary: COL17A1 and CD44 play crucial roles in regulating cell accumulation and metabolic pathways in the early stages of cancer development, suppressing ROS production and promoting multilayer structure formation. These proteins could be potential targets for early diagnosis and preventive treatment of precancerous lesions.

CURRENT BIOLOGY (2021)

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Article Cell Biology

HBx facilitates ferroptosis in acute liver failure via EZH2 mediated SLC7A11 suppression

Guo-Zhen Liu et al.

Summary: ALF is a severe syndrome with high mortality, often caused by HBV infection. Studies have shown that HBx facilitates ferroptosis in ALF by suppressing SLC7A11 through EZH2-mediated histone modification.

JOURNAL OF BIOMEDICAL SCIENCE (2021)

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Article Oncology