CD58 acts as a tumor promotor in hepatocellular carcinoma via activating the AKT/GSK-3 beta/beta-catenin pathway

Article Cell Biology

Glioma-derived LRIG3 interacts with NETO2 in tumor-associated macrophages to modulate microenvironment and suppress tumor growth

Youwei Li et al.

Summary: Soluble LRIG3 (sLRIG3) derived from glioma tumor cells can inhibit the M2 polarization of tumor-associated macrophages (TAMs) by interacting with NETO2, thus suppressing glioblastoma multiforme (GBM) malignant progression.

CELL DEATH & DISEASE (2023)

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Article Oncology

Attacking the PI3K/Akt/mTOR signaling pathway for targeted therapeutic treatment in human cancer

Le Yu et al.

Summary: This article reviews the mechanisms leading to the hyperactivation of PI3K/Akt/mTOR signaling in cancer and summarizes the efforts in developing PI3K/Akt/mTOR inhibitors as monotherapy or combination therapy in different cancer settings. Targeting the PI3K/Akt/mTOR signaling pathway through the development of new agents, drug delivery systems, or combination regimens provides insights into possible future directions for targeted therapeutic regimen and effective patient stratification strategy to improve clinical outcomes for cancer patients with deregulated PI3K/Akt/mTOR signaling.

SEMINARS IN CANCER BIOLOGY (2022)

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Article Multidisciplinary Sciences

Ivermectin represses Wnt/β-catenin signaling by binding to TELO2, a regulator of phosphatidylinositol 3-kinase-related kinases

Honami Yonezawa et al.

Summary: This study reveals that IVM inhibits PIKKs and reduces cytoplasmic β-catenin levels by binding to TELO2 protein. This finding suggests TELO2 as a potential druggable target for human diseases involving the Wnt/β-catenin pathway and PIKKs.

ISCIENCE (2022)

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Review Pharmacology & Pharmacy

AKT/GSK-3 Pathway Targeting; Botanicals and Bioactive Compounds with Anti-cancer Activities

Atefeh Jalali et al.

Summary: This research focuses on reviewing effective herbal medicines targeting the Akt/GSK-3 signaling pathway in cancer progression. The inhibition of Akt/GSK-3 can lead to apoptotic activity, anti-proliferative effects, and anti-metastatic effects in cancer cells. A total of 64 plants or bioactive components with anticancer activity were identified for potential human trials.

CURRENT PHARMACEUTICAL DESIGN (2021)

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Article Oncology

SIK2 represses AKT/GSK3β/β-catenin signaling and suppresses gastric cancer by inhibiting autophagic degradation of protein phosphatases

Xiao-man Dai et al.

Summary: SIK2 acts as a tumor suppressor in gastric cancer by inhibiting the AKT/GSK3 beta/beta-catenin signaling pathway and suppressing epithelial-mesenchymal transition. Reduced expression of SIK2 is associated with poor prognosis in patients with gastric cancer. These findings suggest that SIK2 may serve as a novel prognostic biomarker and therapeutic target for gastric cancer.

MOLECULAR ONCOLOGY (2021)

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Article Oncology

TELO2 induced progression of colorectal cancer by binding with RICTOR through mTORC2

Zheng Guo et al.

Summary: Colorectal cancer is a common cancer with limited treatment strategies. This study shows that TELO2 is significantly upregulated in CRC, and its inhibition can restrain cell growth, cell cycle, and metastasis. TELO2 overexpression is positively correlated with age, lymph node metastasis, and TNM stage in CRC patients.

ONCOLOGY REPORTS (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Endocrinology & Metabolism

Neural Cell Adhesion Molecule Regulates Osteoblastic Differentiation Through Wnt/β-Catenin and PI3K-Akt Signaling Pathways in MC3T3-E1 Cells

Bin-Feng Cheng et al.

Summary: NCAM regulates osteoblast differentiation through activation of the Wnt/β-catenin and PI3K-Akt signaling pathways, with its silencing inhibiting osteoblastic differentiation in various cell lines.

FRONTIERS IN ENDOCRINOLOGY (2021)

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Article Immunology

Identification of Key Functional Modules and Immunomodulatory Regulators of Hepatocellular Carcinoma

Ding Luo et al.

Summary: This study identified potential therapeutic targets and immunomodulatory regulators for HCC through differential expression analysis and weighted gene coexpression network analysis, providing insights for the development of new cancer immunotherapies.

JOURNAL OF IMMUNOLOGY RESEARCH (2021)

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Review Immunology

CD58 Immunobiology at a Glance

Yalu Zhang et al.

Summary: CD58 glycoprotein is a costimulatory receptor widely distributed on human tissue cells, which interacts with its ligand CD2 to activate and proliferate T/NK cells, as well as promote cell adhesion and recognition. Soluble CD58 plays a crucial role in immunosuppression and tumor microenvironment.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Oncology