期刊
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
卷 -, 期 -, 页码 -出版社
SPRINGER
DOI: 10.1007/s10973-023-12635-x
关键词
Polysaccharides; Amide anesthetics; Biopolymer films; Drug delivery; kappa-Carrageenan; HEC
A new type of polysaccharide film containing amide-type anesthetics was synthesized in this study. The stability of these films suggests their potential use as carriers for local anesthesia.
The need for delivery systems based on biopolymers led this study to the synthesis of a new type of polysaccharide film. Thus, two distinct types of films were obtained in which amide-type anesthetics were incorporated. In the composition of type A films, kappa-carrageenan and glycerol are found, while in the composition of type B films, hydroxyethyl cellulose (HEC) is also included. The addition of the second polysaccharide (HEC) to the base composition makes the B-type films exhibit parafilm-like elasticity. FTIR study indicates successful incorporation of anesthetics without affecting the integrity of the polysaccharide matrix. Through TG/DTG and DSC studies, it is highlighted that the active substances are stable in the range of 37-100 degrees C, as well as the polysaccharides that have been chosen as a film base. Thus, all the data obtained from this study indicate that these films can be used as a local anesthetic carrier for possible transdermal drug delivery.
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