Bazi Bushen maintains intestinal homeostasis through inhibiting TLR4/NFκB signaling pathway and regulating gut microbiota in SAMP6 mice

Article Gastroenterology & Hepatology

Patient-Reported Outcomes Correlate With Microbial Community Composition Independent of Mucosal Inflammation in Pediatric Inflammatory Bowel Disease

Jennifer Hellmann et al.

Summary: Microbial community composition is associated with patient-reported outcomes (PROs) in both ulcerative colitis (UC) and Crohn's disease (CD). Metabolic pathways differ relative to PROs in UC, but not CD.

INFLAMMATORY BOWEL DISEASES (2023)

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Article Medicine, Research & Experimental

Bazi Bushen mitigates epigenetic aging and extends healthspan in naturally aging mice

Xinjing Mao et al.

Summary: This study explored the antiaging effects of Bazi Bushen (BZBS), a traditional Chinese medicine, in naturally aging mice. The results showed that BZBS treatment restored age-associated methylation decline and rejuvenated methylation age. In addition, BZBS improved memory and muscular endurance, reduced frailty score and liver pathological changes. Overall, this research revealed the potential of BZBS in extending healthspan and provided insights into its mechanism of action in age-related disease treatment.

BIOMEDICINE & PHARMACOTHERAPY (2023)

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Article Pharmacology & Pharmacy

Ginsenoside Rg1 ameliorated experimental colitis by regulating the balance of M1/M2 macrophage polarization and the homeostasis of intestinal flora

Jian Long et al.

Summary: Ginsenoside Rg1 ameliorates ulcerative colitis by regulating M1/M2 macrophage polarization and microbiota composition, associated with inhibition of the Nogo-B/RhoA signaling pathway.

EUROPEAN JOURNAL OF PHARMACOLOGY (2022)

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Article Plant Sciences

BaZiBuShen alleviates cognitive deficits and regulates Sirt6/NRF2/HO-1 and Sirt6/P53-PGC-1α-TERT signaling pathways in aging mice

Lin Li et al.

Summary: The study found that BZBS can improve cognitive and motor functions in aging mice, maintain redox balance, alleviate immunosenescence, and preserve telomerase activity and length. Additionally, BZBS can inhibit rapid aging in mice by reducing the expressions of P53, caspase-3, and Bax, while increasing the expressions of Sirt6, p-HO-1, p-NRF2, PGC-1 alpha, and Bcl-2.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Biochemistry & Molecular Biology

Chlorogenic acid improves the intestinal barrier by relieving endoplasmic reticulum stress and inhibiting ROCK/MLCK signaling pathways

Luqing Song et al.

Summary: The phenolic acid CGA can protect the intestinal barrier by inhibiting ROCK/MLCK signaling pathways and relieving ER stress. Three other substances were also found to stabilize intestinal homeostasis.

FOOD & FUNCTION (2022)

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Article Geriatrics & Gerontology

Age-related morphological and functional changes in the small intestine of senescence-accelerated mouse

Takuji Suzuki et al.

Summary: The ability of the small intestine to perform various functions declines with age and the mechanism that causes intestinal senescence remains unclear. This study evaluated age-related changes in the jejunum and ileum of mice and found that disorders affecting the differentiation/maturation system of intestinal epithelial cells contribute to spontaneous senescence of the small intestine. Brain dysfunction was also observed to enhance intestinal senescence. The brain-intestinal nervous system may play a role in maintaining villous morphology and nutrients uptake.

EXPERIMENTAL GERONTOLOGY (2022)

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Review Gastroenterology & Hepatology

Akkermansia muciniphila: paradigm for next-generation beneficial microorganisms

Patrice D. Cani et al.

Summary: This article reviews the discovery of Akkermansia muciniphila and its association with health and disease. Studies have shown that A. muciniphila can improve health through various mechanisms and comparisons are made with other next-generation beneficial microorganisms.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2022)

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Article Toxicology

Schisandrin A alleviates mycophenolic acid-induced intestinal toxicity by regulating cell apoptosis and oxidative damage

Yiyun Deng et al.

Summary: The active component Schisandrin A (Sch A) in Schisandra chinensis can protect intestinal epithelial cells from mycophenolic acid-induced damage, reducing oxidative stress and inhibiting the MAPK signaling pathway.

TOXICOLOGY MECHANISMS AND METHODS (2022)

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Article Multidisciplinary Sciences

Akkermansia muciniphila phospholipid induces homeostatic immune responses

Munhyung Bae et al.

Summary: This study identifies a lipid molecule from Akkermansia muciniphila's cell membrane that exhibits immunomodulatory activity through the Toll-like receptor TLR2-TLR1 pathway. The findings provide molecular insights into the role of Akkermansia muciniphila in regulating immune balance and its impact on health and disease.

NATURE (2022)

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Article Pharmacology & Pharmacy

Relief Effects of Icariin on Inflammation-Induced Decrease of Tight Junctions in Intestinal Epithelial Cells

Yanli Li et al.

Summary: This study explores the potential therapeutic effects of Icariin (ICA) on inflammation-associated intestinal barrier function impairment in aging. The results show that ICA can alleviate the down-regulation of tight junctions and reduce the expression of inflammatory cytokines. It is also found that ICA exerts its effects by suppressing oxidative stress and decreasing miR-122a expression. These findings suggest that ICA may have a protective effect on intestinal barrier function and could be a potential treatment for colitis.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Immunology

Glycyrrhetinic acid regulates impaired macrophage autophagic flux in the treatment of non-alcoholic fatty liver disease

Yadong Fan et al.

Summary: Glycyrrhetinic acid (GA) has therapeutic effects on non-alcoholic fatty liver disease (NAFLD) by regulating the STAT3-HIF-1α pathway in macrophages, improving impaired autophagy flux, and reducing excessive production of inflammatory cytokines, thus alleviating excessive hepatocyte apoptosis.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Gastroenterology & Hepatology

The role of goblet cells and mucus in intestinal homeostasis

Jenny K. Gustafsson et al.

Summary: Mucus produced by goblet cells plays a crucial role in intestinal health and disease, with complex regulatory mechanisms. The mucus layer formed by goblet cell secretion serves as a protective barrier in the intestines, closely linked to the immune system, and essential for maintaining intestinal homeostasis.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2022)

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Review Pharmacology & Pharmacy

Traditional Chinese Medicine: A promising strategy to regulate inflammation, intestinal disorders and impaired immune function due to sepsis

Xu-Hua Wang et al.

Summary: This paper discusses the interaction between intestinal microbiota and sepsis, and explores the use of traditional Chinese medicine (TCM) in the treatment of sepsis.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Endocrinology & Metabolism

Lactobacillus rhamnosus GG Promotes Intestinal Vitamin D Absorption by Upregulating Vitamin D Transporters in Senile Osteoporosis

Jing Cheng et al.

Summary: The study suggests that Lactobacillus rhamnosus GG culture supernatant (LCS) can promote intestinal absorption of cholecalciferol by affecting protein levels of VD transporters, thus improving the levels of 25OHD(3) in senile osteoporosis (SOP).

CALCIFIED TISSUE INTERNATIONAL (2022)

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Article Immunology

Parabacteroides distasonis induces depressive-like behavior in a mouse model of Crohn's disease

Adrian Gomez-Nguyen et al.

Summary: Patients with inflammatory bowel disease are prone to behavioral diagnoses, and recent studies have shown that the microbiome may play a role in influencing behavior. A specific bacterial genus, Parabacteroides, has been identified as capable of inducing depressive-like behavior in a mouse model of Crohn's disease.

BRAIN BEHAVIOR AND IMMUNITY (2021)

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Article Biochemistry & Molecular Biology

Scutellaria baicalensis Georgi polysaccharide ameliorates DSS-induced ulcerative colitis by improving intestinal barrier function and modulating gut microbiota

Li Cui et al.

Summary: SP2-1 polysaccharide from Scutellaria baicalensis Georgi shows protective effects against ulcerative colitis by improving pathological damage, reducing weight loss, and repairing intestinal barrier. Additionally, it significantly increases beneficial bacteria and inhibits the growth of harmful bacteria.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Plant Sciences

BaZiBuShen alleviates altered testicular morphology and spermatogenesis and modulates Sirt6/P53 and Sirt6/NF-κB pathways in aging mice induced by D-galactose and NaNO2

Lin Li et al.

Summary: BZBS medication can preserve sperm and testicular morphology in aging mice, increase serum antioxidant capacity, hormone levels, and maintain testicular morphology and sperm quality by improving oxidative stress and regulating signaling pathways.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

Ginsenoside Rg1 prevents bone marrow mesenchymal stem cell senescence via NRF2 and PI3K/Akt signaling

Ziling Wang et al.

Summary: The study revealed that ginsenoside Rg1 can prevent MSCs from entering senescence state by activating the NRF2 and AKT pathways, enhancing cell antioxidant capacity. This discovery provides new therapeutic targets for preventing cell senescence.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

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Article Immunology

Evaluation of the Anti-Aging Effects of a Probiotic Combination Isolated From Centenarians in a SAMP8 Mouse Model

Xin Fang et al.

Summary: Population aging is a global issue, and the research on probiotic combination from centenarians has shown promising anti-aging effects in SAMP8 mice by improving cognitive and motor functions through regulating intestinal microbiota and inhibiting TLR4/NF kappa B-induced inflammation. This research provides a basis for the future development and application of probiotic combination.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

Medicinal Plant Leaf Extract From Sage and Lemon Verbena Promotes Intestinal Immunity and Barrier Function in Gilthead Seabream (Sparus aurata)

Ricardo Salomon et al.

Summary: The study showed that the inclusion of medicinal plant leaf extract from sage and lemon verbena in the diet of gilthead seabream had beneficial effects on gut health, supporting gut homeostasis and increasing the integrity of the intestinal epithelium.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Pharmacology & Pharmacy

Bazi Bushen Capsule Alleviates Post-Menopausal Atherosclerosis via GPER1-Dependent Anti-Inflammatory and Anti-Apoptotic Effects

Dan Huang et al.

Summary: The study demonstrated the anti-atherosclerotic effect of Bazi Bushen capsule through experiments with Ovx/ApoE(-/-) mice and human umbilical vein endothelial cells, indicating a potential mechanism involving GPER1-dependent anti-inflammatory and anti-apoptotic actions.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Pharmacology & Pharmacy

Probiotics modulate the microbiota-gut-brain axis and improve memory deficits in aged SAMP8 mice

Xueqin Yang et al.

ACTA PHARMACEUTICA SINICA B (2020)

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Article Gastroenterology & Hepatology

Gut microbiota shape 'inflamm-ageing' cytokines and account for age-dependent decline in DNA damage repair

Avital Guedj et al.

GUT (2020)

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Article Biotechnology & Applied Microbiology

Lizhong decoction ameliorates ulcerative colitis in mice via modulating gut microbiota and its metabolites

Junfeng Zou et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2020)

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Article Medicine, Research & Experimental

Sanhuang Shu'ai decoction alleviates DSS-induced ulcerative colitis via regulation of gut microbiota, inflammatory mediators and cytokines

Zi-cong Wu et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Health Care Sciences & Services

Chinese medicine Bazi Bushen capsule improves lipid metabolism in ovariectomized female ApoE(-/-) mice

Dan Huang et al.

ANNALS OF PALLIATIVE MEDICINE (2020)

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Article Medicine, Research & Experimental

Intestinal alkaline phosphatase targets the gut barrier to prevent aging

Florian Kuehn et al.

JCI INSIGHT (2020)

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Article Multidisciplinary Sciences

Age-associated Impairment of the Mucus Barrier Function is Associated with Profound Changes in Microbiota and Immunity

Bruno Sovran et al.

SCIENTIFIC REPORTS (2019)

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Article Pharmacology & Pharmacy

Schisandrin B prevents ulcerative colitis and colitis-associated-cancer by activating focal adhesion kinase and influence on gut microbiota in an in vivo and in vitro model

Jiani Li et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2019)

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Article Multidisciplinary Sciences

Potential roles of gut microbiome and metabolites in modulating ALS in mice

Eran Blacher et al.

NATURE (2019)

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Article Biochemistry & Molecular Biology

Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice

Clea Barcena et al.

NATURE MEDICINE (2019)

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Article Multidisciplinary Sciences

Akkermansia muciniphila induces intestinal adaptive immune responses during homeostasis

Eduard Ansaldo et al.

SCIENCE (2019)

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Review Nutrition & Dietetics

Gut Microbiota and Obesity: A Role for Probiotics

Ludovico Abenavoli et al.

NUTRIENTS (2019)

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Review Biochemistry & Molecular Biology

An insight into gut microbiota and its functionalities

Atanu Adak et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2019)

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Article Biochemistry & Molecular Biology

Chlorogenic acid improves intestinal barrier functions by suppressing mucosa inflammation and improving antioxidant capacity in weaned pigs

Jiali Chen et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2018)

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Review Biology

Morphological and molecular characterization of the senile osteoporosis in senescence-accelerated mouse prone 6 (SAMP6)

Kagaku Azuma et al.

MEDICAL MOLECULAR MORPHOLOGY (2018)

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Article Biochemistry & Molecular Biology

A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

Hubert Plovier et al.

NATURE MEDICINE (2017)

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Article Clinical Neurology

A preliminary examination of gut microbiota, sleep, and cognitive flexibility in healthy older adults

Jason R. Anderson et al.

SLEEP MEDICINE (2017)

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Review Biochemistry & Molecular Biology

Roles of intestinal epithelial cells in the maintenance of gut homeostasis

Ryu Okumura et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2017)

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Review Medicine, General & Internal

Interaction between the gut microbiome and mucosal immune system

Na Shi et al.

MILITARY MEDICAL RESEARCH (2017)

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Review Multidisciplinary Sciences

The microbiota in adaptive immune homeostasis and disease

Kenya Honda et al.

NATURE (2016)

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Review Multidisciplinary Sciences

The microbiome and innate immunity

Christoph A. Thaiss et al.

NATURE (2016)

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Article Multidisciplinary Sciences

Huangqin-tang ameliorates dextran sodium sulphate-induced colitis by regulating intestinal epithelial cell homeostasis, inflammation and immune response

Ying Zou et al.

SCIENTIFIC REPORTS (2016)

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Article Biotechnology & Applied Microbiology

Evaluating Bias of Illumina-Based Bacterial 16S rRNA Gene Profiles

Katherine Kennedy et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2014)

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Review Immunology

The microbiome and regulation of mucosal immunity

Andrew J. McDermott et al.

IMMUNOLOGY (2014)

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Review Immunology

Intestinal epithelial cells: regulators of barrier function and immune homeostasis

Lance W. Peterson et al.

NATURE REVIEWS IMMUNOLOGY (2014)

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Article Biochemical Research Methods

UCHIME improves sensitivity and speed of chimera detection

Robert C. Edgar et al.

BIOINFORMATICS (2011)

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Article Multidisciplinary Sciences

Human nutrition, the gut microbiome and the immune system

Andrew L. Kau et al.

NATURE (2011)

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Review Biochemistry & Molecular Biology

Enterocyte death and intestinal barrier maintenance in homeostasis and disease

Lars Vereecke et al.

TRENDS IN MOLECULAR MEDICINE (2011)

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Article Biotechnology & Applied Microbiology

Metagenomic biomarker discovery and explanation

Nicola Segata et al.

GENOME BIOLOGY (2011)

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Review Immunology

Development and functional specialization of CD103+dendritic cells

Maria-Luisa del Rio et al.

IMMUNOLOGICAL REVIEWS (2010)

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Review Immunology

Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function

Maria T. Abreu

NATURE REVIEWS IMMUNOLOGY (2010)

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Review Immunology

Intestinal mucosal barrier function in health and disease

Jerrold R. Turner

NATURE REVIEWS IMMUNOLOGY (2009)

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Review Multidisciplinary Sciences

Unravelling the pathogenesis of inflammatory bowel disease

R. J. Xavier et al.

NATURE (2007)

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Article Biochemistry & Molecular Biology

Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis

S Rakoff-Nahoum et al.

CELL (2004)

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Bazi Bushen maintains intestinal homeostasis through inhibiting TLR4/NFκB signaling pathway and regulating gut microbiota in SAMP6 mice

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