4.5 Article

Substantia nigra nigrosome-1 imaging correlates with the severity of motor symptoms in Parkinson's disease

期刊

出版社

ELSEVIER
DOI: 10.1016/j.jns.2023.120731

关键词

-

向作者/读者索取更多资源

This study found that the size of nigrosome-1 is significantly smaller in PD patients compared to controls. The loss and size of nigrosome-1 may potentially assist in the diagnosis of PD and reflect the motor severity of the disease.
Background: Nigrosome-1 imaging has been used for assisting the diagnosis of Parkinson's disease (PD). We aimed to examine the diagnostic performance of loss of nigrosome-1 in PD and the correlation between the size of the nigrosome-1 and motor severity of PD.Methods: We included 237 patients with PD and 165 controls. The motor severity of PD was assessed with the Unified Parkinson's Disease Rating Scale (UPDRS) part III score and Hoehn-Yahr staging. The 3 or 1.5 Tesla susceptibility-weighted imaging combined with a deep-learning algorithm was applied for detecting the loss and the size of nigrosome-1. Clinical correlations and diagnostic performance of size of nigrosome-1 were also investigated.Results: The mean nigrosome-1 size was significantly smaller in PD patients than in controls (0.06 & PLUSMN; 0.07 cm2 vs. 0.20 & PLUSMN; 0.05 cm2, P < 0.001). The area under the receiver operating characteristic curve (AUC) of the established model showed 0.94 accuracy (95% confidence interval [CI]: 0.87, 1.01, P < 0.01) in differentiating between the PD and control groups. Moreover, the partial loss of nigrosome-1 detected with SWI had an AUC of 0.96 in discriminating early-stage PD from controls (95% CI: 0.88, 1.02, P < 0.001). After adjusting for age, sex, disease duration, and levodopa equivalent daily dose, the estimated size of nigrosome-1 was negatively associated with the UPDRS part III motor score (& rho; =-0.433, P < 0.001), but not with Mini-Mental State Examination scores (& rho; = 0.006, P = 0.894).Conclusions: The extent of loss and the size of nigrosome-1 may potentially assist in the diagnosis of PD. Nigrosome-1 size reflects the motor severity of PD.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据