Response to Kang et al.

Review Oncology

Cancer epigenetics in clinical practice

Veronica Davalos et al.

Summary: Cancer development is caused by changes in the structure and function of the genome. Epigenetic alterations regulate gene expression programs that promote tumorigenesis and can be used as useful tools in clinical decision making. Unlike genetic changes, epigenetic modifications can be reversed, making them an attractive target for drug development.

CA-A CANCER JOURNAL FOR CLINICIANS (2023)

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Letter Oncology

RE: Epigenetic profiling and response to CD19 chimeric antigen receptor T-cell therapy in B-cell malignancies

Hwan Young Lee et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2023)

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Article Oncology

Culture expansion of CAR T cells results in aberrant DNA methylation that is associated with adverse clinical outcome

Lucia Salz et al.

Summary: CAR T cell expansion during culture leads to DNA hypermethylation, which downregulates the expression of genes relevant to T cell function. This hypermethylation signature can predict cell culture time and is associated with reduced long-term survival and therapeutic outcome in CAR T cell products.

LEUKEMIA (2023)

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Article Multidisciplinary Sciences

Enhanced cell deconvolution of peripheral blood using DNA methylation for high-resolution immune profiling

Lucas A. Salas et al.

Summary: This study presents a deconvolution method for predicting DNA methylation levels in 12 leukocyte subtypes, expanding to include 56 immune profile variables. The accuracy of the method was validated in various applications, showing its potential for standardized investigation of immune profiles in human health and disease.

NATURE COMMUNICATIONS (2022)

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Article Oncology

Biological and Molecular Factors Predicting Response to Adoptive Cell Therapies in Cancer

Gerardo Ferrer et al.

Summary: Adoptive cell therapy is a personalized treatment approach that utilizes the patient's immune system to target and eliminate cancer cells. While it has shown impressive results in certain types of cancers, there are still limitations such as high costs, technical challenges, side effect management, and a limited population of responders. Therefore, discovering reliable biomarkers to predict treatment success and potential toxicities is crucial.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2022)

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Review Oncology

Clinical implications of T cell exhaustion for cancer immunotherapy

Andrew Chow et al.

Summary: Immunotherapy has been a significant advancement in cancer treatment, with T cells playing a crucial role. However, cancer can lead to T cell exhaustion, a state of decreased function. Previous research focused on alleviating T cell exhaustion, but new findings suggest that it may be both a cause and reflection of poor tumor control. Therefore, interventions to mitigate T cell exhaustion development may lead to superior clinical outcomes in cancer immunotherapy.

NATURE REVIEWS CLINICAL ONCOLOGY (2022)

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Article Biochemistry & Molecular Biology

The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery

Hendrik G. Stunnenberg et al.

CELL (2016)

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Response to Kang et al.

相关参考文献

Cancer epigenetics in clinical practice

RE: Epigenetic profiling and response to CD19 chimeric antigen receptor T-cell therapy in B-cell malignancies

Culture expansion of CAR T cells results in aberrant DNA methylation that is associated with adverse clinical outcome

Enhanced cell deconvolution of peripheral blood using DNA methylation for high-resolution immune profiling

Biological and Molecular Factors Predicting Response to Adoptive Cell Therapies in Cancer

Clinical implications of T cell exhaustion for cancer immunotherapy

The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery

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