Cascade testing for hereditary cancer: comprehensive multigene panels identify unexpected actionable findings in relatives

Summary: This study compared the uptake rates of cascade genetic testing under different indications and found that the testing rate was higher among families of diagnostic probands. A personal or family history of disease may be a contributing factor to the higher testing rate.

Summary: This study evaluated the long-term utilization of targeted cancer prevention and quality of life among at-risk relatives offered clinician-facilitated cascade genetic testing. The results showed that cascade genetic testing resulted in genetically targeted cancer screening and prevention with preserved quality of life.