期刊
JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS
卷 182, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmps.2023.105476
关键词
Tumor microenvironment; Metastasis; Bistability; Morphology; Mechanomedicine
The balance between stress and adhesion plays a crucial role in governing the behaviors of adherent cells, such as cell migration. In certain microenvironments, such as tumor, variations in hydrostatic pressure can significantly impact cell volume and adhesion, which in turn affects cell behavior.
The balance between stress and adhesion governs many behaviors of adherent cells such as cell migration. In certain microenvironments such as that of a tumor, variations in hydrostatic pressure be substantial compared to cell-generated stresses. These variations can affect stressactivated ion channels whose activation can in turn affect cell volume and adhesion. To study these effects, we developed a theoretical model to relate changes in hydrostatic pressure to the morphology and volume of adherent cells. The model predicted the bistability of cell morphology (i.e., a snap-through instability) under hydrostatic pressure for certain ranges of adhesion energy density. This snap-through instability can enable cells to spontaneously detach from their environment, and may have bearing on migration and metastasis.
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