Hidradenitis suppurativa associated telomere-methylome dysregulations in blood

Letter Dermatology

The age of onset of hidradenitis suppurativa correlates with the age of onset of smoking. Comment on cigarette smoking precedes the onset of hidradenitis suppurativa

J. Garcias-Ladaria et al.

INTERNATIONAL JOURNAL OF DERMATOLOGY (2023)

Article Dermatology

Long-term risk of death in patients with hidradenitis suppurativa

John J. Kohorst et al.

Summary: Patients with Hidradenitis suppurativa have a significantly increased overall risk of death, which is particularly dependent on smoking history.

INTERNATIONAL JOURNAL OF DERMATOLOGY (2023)

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Letter Dermatology

Cytochrome P450 Genes Mediated by DNA Methylation Are Involved in the Resistance to Hidradenitis Suppurativa

Uppala Radhakrishna et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2023)

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Letter Dermatology

Passive smoking and hidradenitis suppurativa: a retrospective analysis

Ines Aparicio Martins et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2023)

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Article Dermatology

Hidradenitis suppurativa presents a methylome dysregulation capable to explain the pro-inflammatory microenvironment: Are these DNA methylations potential therapeutic targets?

Uppala Radhakrishna et al.

Summary: This study characterizes epigenetic variations in cytokine genes associated with Hidradenitis suppurativa (HS) by performing DNA methylation profiling. The identified differentially methylated genes may contribute to the pathogenesis of HS.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2023)

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Article Dermatology

Increased epigenetic age acceleration in the hidradenitis suppurativa skin

Danitza Lukac et al.

Summary: This study calculated the epigenetic age acceleration in patients with hidradenitis suppurativa (HS) and found that there were external immune-related changes in the skin of HS patients, suggesting that this acceleration could potentially serve as a biomarker for assessing the disease burden in HS patients.

ARCHIVES OF DERMATOLOGICAL RESEARCH (2023)

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Review Biochemistry & Molecular Biology

Predominant Role of mTOR Signaling in Skin Diseases with Therapeutic Potential

Fani Karagianni et al.

Summary: The mTOR signaling pathway plays a critical role in skin diseases with inflammatory and malignant features. Understanding its function and regulation is of great importance for clinical treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Medicine, General & Internal

Effect of Physical Activity, Smoking, and Sleep on Telomere Length: A Systematic Review of Observational and Intervention Studies

Rocio Barragan et al.

Summary: Reduced sedentary activities, optimal sleep habits, and non- or ex-smoker status have been associated with less telomere shortening.

JOURNAL OF CLINICAL MEDICINE (2022)

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Article Geriatrics & Gerontology

Diabetes mellitus correlates with increased biological age as indicated by clinical biomarkers

Nadine Bahour et al.

Summary: Biological age, determined by cellular changes rather than time of birth, was found to be higher in individuals with diabetes compared to those without, correlating strongly with morbidity, mortality, and survival rates.

GEROSCIENCE (2022)

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Review Genetics & Heredity

The Genomic Architecture of Hidradenitis Suppurativa-A Systematic Review

Nikolai Paul Pace et al.

Summary: This review provides a comprehensive overview of the role of genetics in various aspects of hidradenitis suppurativa, including pathophysiology, diagnosis, and clinical application.

FRONTIERS IN GENETICS (2022)

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Article Dermatology

Methylated miRNAs may serve as potential biomarkers and therapeutic targets for hidradenitis suppurativa

U. Radhakrishna et al.

Summary: This study analyzed the methylation patterns of miRNA genes associated with HS susceptibility and identified several miRNA genes related to skin function and inflammation. This is the first study to analyze the methylation profiles of miRNA genes in the HS population, providing valuable insights for the diagnosis and treatment of HS.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2022)

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Review Materials Science, Biomaterials

Syndromic and Nonsyndromic Obesity: Underlying Genetic Causes in Humans

Jessica Duis et al.

Summary: Growing evidence supports the genetic factors in obesity, with genetic components contributing to 40%-70% of obesity cases. Over 550 obesity-related single genes have been identified, and understanding gene interactions and disease mechanisms is important for early diagnosis, treatment, and understanding risk factors.

ADVANCED BIOLOGY (2022)

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Article Dermatology

Hidradenitis suppurativa is associated with hypothyroidism and hyperthyroidism: a large-scale population-based study

Shany Sherman et al.

Summary: Hidradenitis suppurativa (HS) is independently associated with hypothyroidism, with smoking status playing a major role in the association of HS with hyperthyroidism. The association of HS with hyperthyroidism is significant only in limited subgroups, including females, middle-aged patients, and nonsmokers.

INTERNATIONAL JOURNAL OF DERMATOLOGY (2021)

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Article Biotechnology & Applied Microbiology

Placental DNA methylation profiles in opioid-exposed pregnancies and associations with the neonatal opioid withdrawal syndrome

Uppala Radhakrishna et al.

Summary: Opioid abuse during pregnancy can lead to Neonatal Opioid Withdrawal Syndrome (NOWS). Methylation dysregulation of placental tissue in NOWS development was identified in the study, and accurate AI prediction for NOWS diagnosis was reported. The study showed strong evidence of the importance of methylation dysregulation in NOWS pathophysiology.

GENOMICS (2021)

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Article Psychiatry

Sexuality in Persons With Hidradenitis Suppurativa: Factors Associated With Sexual Desire and Functioning Impairment

Rossella Mattea Quinto et al.

Summary: The study found that sexual life is often hindered in patients with Hidradenitis Suppurativa, with significant associations with factors such as alcohol consumption, low Body Mass Index, family history, and severe skin symptoms. Negative psychological factors also increase the risk of sexual impairment in these patients.

FRONTIERS IN PSYCHIATRY (2021)

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Review Environmental Sciences

The Effect of Alcohol on Telomere Length: A Systematic Review of Epidemiological Evidence and a Pilot Study during Pregnancy

Andrea Maugeri et al.

Summary: Studies have shown a potential association between alcohol consumption and telomere length, with alcohol-related disorders being linked to shorter telomeres. Further research is needed to explore the effects of alcohol consumption during pregnancy on newborns and to understand the molecular mechanisms involved.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

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Article Medicine, General & Internal

Features Associated With Quality of Life Impairment in Hidradenitis Suppurativa Patients

Sylke Schneider-Burrus et al.

Summary: The study in Germany quantified the impairment in quality of life in patients with Hidradenitis suppurativa (HS) and identified parameters associated with the impairment. The degree of impairment was correlated with the severity of skin alterations and specific comorbidities such as adiposity and back pain. Surgical and conventional medicamentous therapies were not associated with long-lasting reduction of quality of life impairment.

FRONTIERS IN MEDICINE (2021)

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Article Dermatology

Hidradenitis Suppurativa From a Patient Perspective Including Symptoms and Self-Treatment

Christina M. Huang et al.

Summary: This study surveyed 41 HS patients and found that the majority were Caucasian, with common symptoms including pain, discharge, malodor, and itch. The most common co-morbidities were depression, and common treatments included antibiotics and surgical excision. Over 90% of patients reported self-treating their lesions.

JOURNAL OF CUTANEOUS MEDICINE AND SURGERY (2021)

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Review Oncology

Hidradenitis suppurativa and psychiatric comorbidities, suicides and substance abuse: systematic review and meta-analysis

Kevin Phan et al.

ANNALS OF TRANSLATIONAL MEDICINE (2020)

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Article Multidisciplinary Sciences

Telomere shortening produces an inflammatory environment that increases tumor incidence in zebrafish

Kirsten Lex et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Health Care Sciences & Services

Analysis of APPL1 Gene Polymorphisms in Patients with a Phenotype of Maturity Onset Diabetes of the Young

Dinara E. Ivanoshchuk et al.

JOURNAL OF PERSONALIZED MEDICINE (2020)

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Review Endocrinology & Metabolism

Association between polymorphisms of NOS1, NOS2 and NOS3 genes and suicide behavior: a systematic review and meta-analysis

Thelma Beatriz Gonzalez-Castro et al.

METABOLIC BRAIN DISEASE (2019)

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Article Endocrinology & Metabolism

Additional Impact of Glucose Tolerance on Telomere Length in Persons With and Without Metabolic Syndrome in the Elderly Ukraine Population

Mykola D. Khalangot et al.

FRONTIERS IN ENDOCRINOLOGY (2019)

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Article Cell Biology

Aging-induced Akt activation involves in aging-related pathologies and Aβ-induced toxicity

Yu-Ru Chen et al.

AGING CELL (2019)

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Article Nutrition & Dietetics

The Safety and Impact of a Model of Intermittent, Time-Restricted Circadian Fasting (Ramadan Fasting) on Hidradenitis Suppurativa: Insights from a Multicenter, Observational, Cross-Over, Pilot, Exploratory Study

Giovanni Damiani et al.

NUTRIENTS (2019)

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Article Genetics & Heredity

A meta-analysis of genome-wide association studies of epigenetic age acceleration

Jude Gibson et al.

PLOS GENETICS (2019)

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Letter Dermatology

Substantially reduced life expectancy in patients with hidradenitis suppurativa: a Finnish nationwide registry study

H. Tiri et al.

BRITISH JOURNAL OF DERMATOLOGY (2019)

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Article Oncology

PIK3CD induces cell growth and invasion by activating AKT/GSK-3β/β-catenin signaling in colorectal cancer

Jing-Song Chen et al.

CANCER SCIENCE (2019)

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Review Biochemistry & Molecular Biology

FOXO3 on the Road to Longevity: Lessons From SNPs and Chromatin Hubs

Paola Sanese et al.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2019)

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Article Dermatology

Opioid, alcohol, and cannabis misuse among patients with hidradenitis suppurativa: A population-based analysis in the United States

Amit Garg et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2018)

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Article Dermatology

Validation of a visual-aided questionnaire for the self-assessment of hidradenitits suppurativa

S. Cazzaniga et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2018)

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Review Medicine, General & Internal

Relationship between short telomere length and stroke A meta-analysis

Xiao Jin et al.

MEDICINE (2018)

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Editorial Material Pharmacology & Pharmacy

Painful Understanding of VEGF

Maria Llorian-Salvador et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Review Immunology

Hidradenitis Suppurativa: A Systematic Review Integrating Inflammatory Pathways Into a Cohesive Pathogenic Model

Allard R. J. V. Vossen et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Letter Rheumatology

Autoinflammatory Disease Damage Index (ADDI): a possible newborn also in hidradenitis suppurativa daily practice

Giovanni Damiani et al.

ANNALS OF THE RHEUMATIC DISEASES (2017)

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Review Environmental Sciences

Cigarette smoking and telomere length: A systematic review of 84 studies and meta-analysis

Yuliana Astuti et al.

ENVIRONMENTAL RESEARCH (2017)

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Letter Dermatology

Acne and Telomere Length: A New Spectrum between Senescence and Apoptosis Pathways

Simone Ribero et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2017)

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Article Clinical Neurology

Chronic Pain and Telomere Length in Community-Dwelling Adults: Findings From the 1999 to 2002 National Health and Nutrition Examination Survey

Alta M. Steward et al.

JOURNAL OF PAIN (2017)

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Article Dermatology

Patterns of antimicrobial resistance in lesions of hidradenitis suppurativa

Alexander H. Fischer et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2017)

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Review Immunology

Aging, Obesity, and inflammatory Age-Related Diseases

Daniela Frasca et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Article Oncology

Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases A Mendelian Randomization Study

Philip C. Haycock et al.

JAMA ONCOLOGY (2017)

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Article Dermatology

Development and validation of the International Hidradenitis Suppurativa Severity Score System (IHS4), a novel dynamic scoring system to assess HS severity

C. C. Zouboulis et al.

BRITISH JOURNAL OF DERMATOLOGY (2017)

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Article Dermatology

Altered Global 5-Hydroxymethylation Status in Hidradenitis Suppurativa: Support for an Epigenetic Background

Schapoor Hessam et al.

DERMATOLOGY (2017)

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Article Dermatology

The ABC of Hidradenitis Suppurativa: A Validated Glossary on how to Name Lesions

Dan Lipsker et al.

DERMATOLOGY (2016)

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Review Endocrinology & Metabolism

Role of telomeres and associated maintenance genes in Type 2 Diabetes Mellitus: A review

Itty Sethi et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2016)

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Article Dermatology

Expanding the spectrum of -secretase gene mutation-associated phenotypes: two novel mutations segregating with familial hidradenitis suppurativa (acne inversa) and acne conglobata

Uppala Ratnamala et al.

EXPERIMENTAL DERMATOLOGY (2016)

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Article Biochemistry & Molecular Biology

ReactomePA: an R/Bioconductor package for reactome pathway analysis and visualization

Guangchuang Yu et al.

MOLECULAR BIOSYSTEMS (2016)

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Article Dermatology

New insights into the diagnosis of hidradenitis suppurativa: Clinical presentations and phenotypes

Hessel H. van der Zee et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2015)

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Article Cell Biology

Loss of Nfkb1 leads to early onset aging

Giovanna M. Bernal et al.

AGING-US (2014)

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Review Physiology

THYROID HORMONE REGULATION OF METABOLISM

Rashmi Mullur et al.

PHYSIOLOGICAL REVIEWS (2014)

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Review Oncology

Review of processing and analysis methods for DNA methylation array data

C. S. Wilhelm-Benartzi et al.

BRITISH JOURNAL OF CANCER (2013)

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Article Biotechnology & Applied Microbiology

Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis

Yun Liu et al.

NATURE BIOTECHNOLOGY (2013)

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Article Biochemical Research Methods

GO-function: deriving biologically relevant functions from statistically significant functions

Jing Wang et al.

BRIEFINGS IN BIOINFORMATICS (2012)

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Article Endocrinology & Metabolism

Telomeres, lifestyle, cancer, and aging

Masood A. Shammas

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2011)

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Letter Dermatology

Hidradenitis suppurativa (or Acne inversa) with autosomal dominant inheritance is not linked to chromosome 1p21.1-1q25.3 region

Faiza Mohamed Saleh Al-Ali et al.

EXPERIMENTAL DERMATOLOGY (2010)

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Review Genetics & Heredity

The genetics of obesity: FTO leads the way

Katherine A. Fawcett et al.

TRENDS IN GENETICS (2010)

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Article Oncology

Polymorphisms in Telomere Maintenance Genes and Risk of Lung Cancer

Jin Eun Choi et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2009)

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Review Biochemistry & Molecular Biology

Chromosome End Maintenance by Telomerase

Jennifer L. Osterhage et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

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Article Biochemistry & Molecular Biology

Importance of randomization in microarray experimental designs with Illumina platforms

Ricardo A. Verdugo et al.

NUCLEIC ACIDS RESEARCH (2009)

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Article Respiratory System

Telomere shortening in smokers with and without COPD

M Morlá et al.

EUROPEAN RESPIRATORY JOURNAL (2006)

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Article Medicine, General & Internal

Obesity, cigarette smoking, and telomere length in women

AM Valdes et al.

LANCET (2005)

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Hidradenitis suppurativa associated telomere-methylome dysregulations in blood

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