☆ 4.6 Letter

Ischemic cerebral stroke risk under psoriasis and psoriatic arthritis treatment: A real-world observational study from the French national healthcare system database

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2023)

Potential cerebrovascular accident signal for risankizumab: A disproportionality analysis of the FDA Adverse Event Reporting System (FAERS)

Richard H. Woods

Summary: This study found a previously unreported signal of disproportionate cerebrovascular accident (CVA) reporting associated with the real-world use of risankizumab for the treatment of plaque psoriasis. Further long-term observational data is necessary to better characterize this unconfirmed potential safety signal.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2023)

添加到收藏夹

Review Immunology

Interleukin-17 Links Inflammatory Cross-Talks Between Comorbid Psoriasis and Atherosclerosis

Yan Wang et al.

Summary: Psoriasis is associated with an increased risk of cardiovascular disease. Clinical studies have shown that IL-17A inhibitors can effectively improve both psoriasis and atherosclerosis symptoms, suggesting that IL-17A may play a crucial role in the comorbidity of these two diseases.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹

Article Behavioral Sciences

Apremilast exerts protective effects on stroke outcomes and blood-brain barrier (BBB) dysfunction through regulating Rho-associated protein kinase 2 expression

Mingyuan Wang et al.

Summary: In this study, the researchers investigated the effects of APR on stroke outcomes and blood-brain barrier (BBB) dysfunction using a mouse model of middle cerebral artery occlusion (MCAO). The results showed that APR attenuated neurological injury, reduced infarct size, and improved grip strength in MCAO mice. APR treatment also helped restore BBB function and reduce neuroinflammation. In vitro experiments demonstrated that APR improved endothelial cell permeability and restored the expression of Claudin-5. These findings suggest that APR has potential as a therapeutic intervention for ischemic stroke by targeting BBB dysfunction and neuroinflammation.

BRAIN AND BEHAVIOR (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

French administrative health care database (SNDS): The value of its enrichment

Lucie-Marie Scailteux et al.

THERAPIE (2019)

添加到收藏夹

Article Public, Environmental & Occupational Health

The national healthcare system claims databases in France, SNIIRAM and EGB: Powerful tools for pharmacoepidemiology

Julien Bezin et al.

PHARMACOEPIDEMIOLOGY AND DRUG SAFETY (2017)

添加到收藏夹

Article Dermatology

Psoriasis and the Risk of Major Cardiovascular Events: Cohort Study Using the Clinical Practice Research Datalink

Rosa Parisi et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2015)

添加到收藏夹

Article Medicine, General & Internal

Attributable Risk Estimate of Severe Psoriasis on Major Cardiovascular Events

Nehal N. Mehta et al.

AMERICAN JOURNAL OF MEDICINE (2011)

添加到收藏夹

Ischemic cerebral stroke risk under psoriasis and psoriatic arthritis treatment: A real-world observational study from the French national healthcare system database

相关参考文献

Potential cerebrovascular accident signal for risankizumab: A disproportionality analysis of the FDA Adverse Event Reporting System (FAERS)

Interleukin-17 Links Inflammatory Cross-Talks Between Comorbid Psoriasis and Atherosclerosis

Apremilast exerts protective effects on stroke outcomes and blood-brain barrier (BBB) dysfunction through regulating Rho-associated protein kinase 2 expression

French administrative health care database (SNDS): The value of its enrichment

The national healthcare system claims databases in France, SNIIRAM and EGB: Powerful tools for pharmacoepidemiology

Psoriasis and the Risk of Major Cardiovascular Events: Cohort Study Using the Clinical Practice Research Datalink

Attributable Risk Estimate of Severe Psoriasis on Major Cardiovascular Events

导出引文

分享论文