☆ 4.7 Review

Antithrombotic Therapy for Primary and Secondary Prevention of Ischemic Stroke JACC State-of-the-Art Review

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2023)

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Article Cardiac & Cardiovascular Systems

Efficacy and safety of edoxaban in patients early after surgical bioprosthetic valve implantation or valve repair: A randomized clinical trial

Chi Young Shim et al.

Summary: This study compared the efficacy and safety of edoxaban with warfarin in patients early after surgical bioprosthetic valve implantation or valve repair. The results showed that edoxaban is noninferior to warfarin for preventing thromboembolism and is potentially comparable for risk of major bleeding.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2023)

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Article Pharmacology & Pharmacy

Antiplatelet therapy for secondary prevention of lacunar stroke: a systematic review and network meta-analysis

Xiaowen Hou et al.

Summary: This meta-analysis compares the efficacy of different antiplatelet therapies for secondary prevention of lacunar stroke (LS) and suggests that cilostazol may be the most effective treatment option.

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2023)

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Article Clinical Neurology

Dual Antiplatelet Therapy With Cilostazol for Secondary Prevention in Lacunar Stroke: Subanalysis of the CSPS.com Trial

Yasuhiro Nishiyama et al.

Summary: This study compared the safety and effectiveness of long-term dual antiplatelet therapy (DAPT) and single antiplatelet therapy (SAPT) in preventing recurrent strokes in patients with lacunar stroke. The results showed that DAPT using cilostazol significantly reduced the incidence of recurrent ischemic stroke without increasing the risk of severe or life-threatening bleeding.

STROKE (2023)

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Article Clinical Neurology

Rationale and design of a randomised double-blind 2x2 factorial trial comparing the effect of a 3-month intensive statin and antiplatelet therapy for patients with acute mild ischaemic stroke or high-risk TIA with intracranial or extracranial atherosclerosis (INSPIRES)

Ying Gao et al.

Summary: This study aims to evaluate the efficacy and safety of intensive antiplatelet and statin treatments initiated within 24-72 hours of cerebral ischaemic events caused by intracranial or extracranial atherosclerosis. 6100 individuals aged 35-80 who have experienced a mild ischaemic stroke or high-risk transient ischaemic attack will be enrolled. The primary outcome is the occurrence of any new stroke within 90 days after randomisation.

STROKE AND VASCULAR NEUROLOGY (2023)

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Article Cardiac & Cardiovascular Systems

Pharmacology and Clinical Development of Factor XI Inhibitors

Antonio Greco et al.

Summary: Therapeutic anticoagulation is used to prevent or treat blood clots, but it can increase the risk of bleeding. Inhibitors of Factor XI (FXI) show promise in reducing the adverse events of anticoagulation. Large-scale phase 3 clinical trials are needed to confirm the role of FXI inhibitors and determine their clinical indications.

CIRCULATION (2023)

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Article Cardiac & Cardiovascular Systems

SCAI/HRS Expert Consensus Statement on Transcatheter Left Atrial Appendage Closure

Jacqueline Saw et al.

Summary: Left atrial appendage closure (LAAC) has rapidly developed in the past few decades, significantly reducing thromboembolic risk associated with atrial fibrillation. The technology has been widely used and continuously improved, providing effective treatment options for patients. An updated consensus statement has been proposed recently to provide evidence-based recommendations and best practices for transcatheter LAAC.

JACC-CARDIOVASCULAR INTERVENTIONS (2023)

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Article Medicine, General & Internal

Early versus Later Anticoagulation for Stroke with Atrial Fibrillation

Urs Fischer et al.

Summary: This study aimed to compare the effect of early initiation versus later initiation of direct oral anticoagulants (DOACs) on acute ischemic stroke in patients with atrial fibrillation. The results showed that there was no significant difference in the incidence of recurrent ischemic stroke, systemic embolism, major extracranial bleeding, symptomatic intracranial hemorrhage, or vascular death within 30 days between early and later use of DOACs.

NEW ENGLAND JOURNAL OF MEDICINE (2023)

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Article Clinical Neurology

Isosorbide Mononitrate and Cilostazol Treatment in Patients With Symptomatic Cerebral Small Vessel Disease The Lacunar Intervention Trial-2 (LACI-2) Randomized Clinical Trial

Joanna M. Wardlaw et al.

Summary: The study tested the feasibility, drug tolerability, safety, and effects of 1-year isosorbide mononitrate (ISMN) and cilostazol treatment on vascular, functional, and cognitive outcomes in patients with lacunar stroke. The results showed that ISMN and cilostazol reduced recurrent stroke, dependence, and cognitive impairment, and improved quality of life, with no safety concerns. These agents could prevent other adverse outcomes in cerebral small vessel disease (cSVD) and should be tested in large phase 3 trials.

JAMA NEUROLOGY (2023)

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Article Cardiac & Cardiovascular Systems

Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association

Connie W. Tsao et al.

Summary: The American Heart Association, in collaboration with the National Institutes of Health, releases annual statistics on heart disease, stroke, and cardiovascular risk factors. The Statistical Update provides the latest data on various heart and circulatory diseases and their outcomes, as well as information on core health behaviors and factors contributing to cardiovascular health.

CIRCULATION (2023)

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Article Cardiac & Cardiovascular Systems

Left atrial appendage occlusion

David R. Holmes Jr et al.

Summary: Prevention of stroke is crucial in health systems, and various methods have been developed for different patient groups. These methods include oral anticoagulation, revascularization procedures, device closure, and left atrial appendage occlusion.

EUROINTERVENTION (2023)

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Article Public, Environmental & Occupational Health

Primary stroke prevention worldwide: translating evidence into action

Mayowa O. Owolabi et al.

Summary: Stroke is a major global threat to life and disability, particularly in low- and middle-income countries that struggle to address its challenges. This article provides an overview of primary stroke prevention, estimating the cost and identifying deficiencies in guidelines and primary prevention approaches. Pragmatic solutions are offered, emphasizing the role of governments and population-wide strategies. Implementation of primary stroke prevention involves various stakeholders across the lifespan.

LANCET PUBLIC HEALTH (2022)

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Article Medicine, General & Internal

Safety of the oral factor XIa inhibitor asundexian compared with apixaban in patients with atrial fibrillation (PACIFIC-AF): a multicentre, randomised, double-blind, double-dummy, dose-finding phase 2 study

Jonathan P. Piccini et al.

Summary: This study compared the incidence of bleeding in patients with atrial fibrillation between Asundexian and apixaban, showing that Asundexian resulted in lower rates of bleeding compared with standard dosing of apixaban.

LANCET (2022)

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Review Clinical Neurology

Review and update of the concept of embolic stroke of undetermined source

Hans-Christoph Diener et al.

Summary: This review discusses the concept of embolic stroke of undetermined source (ESUS) and proposes updates to the criteria and diagnostic algorithm based on recent evidence. The neutral results of anticoagulation trials and insights into ESUS from research conducted since the concept was introduced warrant reassessment of ESUS as a research concept and a treatment target.

NATURE REVIEWS NEUROLOGY (2022)

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Review Clinical Neurology

Contemporary antiplatelet therapy for secondary stroke prevention: a narrative review of current literature and guidelines

Jay Shah et al.

Summary: This narrative review provides an overview of the current evidence and recommendations for antiplatelet therapy in stroke prevention. Single-antiplatelet therapy is effective in reducing the risk of recurrent stroke in patients with non-cardioembolic stroke or TIA, while dual-antiplatelet therapy is more effective in high-risk patients. Prolonged use of dual-antiplatelet therapy is associated with higher risk of hemorrhage without reducing stroke recurrence.

STROKE AND VASCULAR NEUROLOGY (2022)

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Review Cardiac & Cardiovascular Systems

Oral antithrombotic therapy for the prevention of recurrent cerebrovascular events

Davide Capodanno et al.

Summary: Stroke is a common and potentially life-threatening condition caused mainly by ischemia. Transient ischemic attack (TIA) is a lower risk condition that still carries the possibility of future cardiovascular events. Cardioembolic disease and atherothrombosis of large arteries are the most common underlying causes of ischemic stroke and TIA. Antithrombotic therapy plays a central role in the management of these patients, but finding the balance between efficacy and safety is a clinical challenge. Recent trials have provided evidence on the use of anticoagulant and antiplatelet therapy in different subtypes of ischemic stroke or TIA.

EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY (2022)

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Article Cardiac & Cardiovascular Systems

Early Versus Delayed Non-Vitamin K Antagonist Oral Anticoagulant Therapy After Acute Ischemic Stroke in Atrial Fibrillation (TIMING): A Registry-Based Randomized Controlled Noninferiority Study

Jonas Oldgren et al.

Summary: This study compared the efficacy and safety of early versus delayed initiation of non-vitamin K antagonist oral anticoagulants (NOACs) in patients with acute ischemic stroke and atrial fibrillation. The results showed that early initiation of NOAC after acute stroke was noninferior to delayed initiation in terms of preventing recurrent ischemic stroke, symptomatic intracerebral hemorrhage, or all-cause mortality. The early initiation group had numerically lower rates of ischemic stroke and death, and no symptomatic intracerebral hemorrhages were observed.

CIRCULATION (2022)

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Article Cardiac & Cardiovascular Systems

Management of Patients at Risk for and With Left Ventricular Thrombus: A Scientific Statement From the American Heart Association

Glenn N. Levine et al.

Summary: Despite advances in cardiovascular medicine, the diagnosis, prevention, and treatment of left ventricular (LV) thrombus remain challenging. Limited guidelines exist, and current practice faces complex issues such as anticoagulant therapy, diagnostic modalities, and alternative treatments. This American Heart Association scientific statement addresses key clinical management questions and provides practical suggestions based on careful review of study data.

CIRCULATION (2022)

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Article Neurosciences

Rationale and design of the AXIOMATIC-SSP phase II trial: Antithrombotic treatment with factor XIa inhibition to Optimize Management of Acute Thromboembolic events for Secondary Stroke Prevention

Mukul Sharma et al.

Summary: The study aims to evaluate the dose-response relationship of the oral medication Milvexian in patients with ischemic stroke or TIA to reduce the risk of stroke.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2022)

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Article Medicine, General & Internal

Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo- controlled, phase 2b trial

Ashkan Shoamanesh et al.

Summary: In this phase 2b trial, FXIa inhibition with asundexian did not reduce the occurrence of covert brain infarction or ischemic stroke and did not increase the risk of major or clinically relevant non-major bleeding compared to placebo in patients with acute, non-cardioembolic ischemic stroke.

LANCET (2022)

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Editorial Material Medicine, General & Internal

Atrial valvular fibrillation: OAC or VKA?

H. Vaillant et al.

EXERCER-LA REVUE FRANCOPHONE DE MEDECINE GENERALE (2022)

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Review Pharmacology & Pharmacy

Antiplatelet therapy after noncardioembolic ischemic stroke or transient ischemic attack

Lorenzo Scalia et al.

Summary: This review provides an overview of current evidence on antiplatelet therapy for patients with non-cardioembolic stroke or TIA, and suggests recommended drug treatment options and new research directions.

EXPERT REVIEW OF CLINICAL PHARMACOLOGY (2022)

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Article Medicine, General & Internal

Rivaroxaban in Rheumatic Heart Disease-Associated Atrial Fibrillation

S. J. Connolly et al.

Summary: Among patients with rheumatic heart disease-associated atrial fibrillation, vitamin K antagonist therapy leads to a lower rate of a composite of cardiovascular events or death compared to rivaroxaban therapy, without a higher rate of bleeding.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Cardiac & Cardiovascular Systems

2021 ESC/EACTS Guidelines for the management of valvular heart disease

Alec Vahanian et al.

EUROINTERVENTION (2022)

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Article Cardiac & Cardiovascular Systems

2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS)

Gerhard Hindricks et al.

EUROPEAN HEART JOURNAL (2021)

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Article Neurosciences

Characterization of the 'White' Appearing Clots that Cause

Oana Madalina Mereuta et al.

Summary: The study revealed that 'white' clots are primarily composed of platelets and other substances, with a different histological composition compared to the more common 'red' clots. White clots are found to contain higher levels of platelets and collagen/calcification, are associated with smaller occlusions, and are more difficult to remove successfully by aspiration alone compared to 'red' clots.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2021)

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Article Clinical Neurology

Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019

Valery L. Feigin et al.

Summary: Regularly updated data on stroke including incidence, prevalence, mortality, disability, risk factors, and trends are crucial for evidence-based care planning. The Global Burden of Diseases Study provides comprehensive measurement of these metrics. From 1990 to 2019, while age-standardized rates improved, the number of strokes and deaths increased. Low-income countries had the highest stroke-related mortality and DALY rates, with high body-mass index being the fastest-growing risk factor.

LANCET NEUROLOGY (2021)

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Article Medicine, General & Internal

Ticagrelor versus Clopidogrel in CYP2C19 Loss-of-Function Carriers with Stroke or TIA

Yongjun Wang et al.

Summary: This study compared ticagrelor and clopidogrel for the secondary prevention of stroke in Chinese patients with minor ischemic stroke or TIA who carried CYP2C19 loss-of-function alleles. The results showed that ticagrelor was associated with a modestly lower risk of stroke at 90 days compared to clopidogrel, with no difference in severe or moderate bleeding risk between the two treatment groups.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Peripheral Vascular Disease

Efficacy and Safety of Prasugrel by Stroke Subtype: A Sub-Analysis of the PRASTRO-1 Randomized Controlled Trial

Takanari Kitazono et al.

Summary: The efficacy of prasugrel may vary among different stroke subtypes, indicating the need for further studies.

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS (2021)

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Correction Cardiac & Cardiovascular Systems

2020 ACC/AHA Guideline on the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines (vol 77, pg e25, 2021)

Otto

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

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Review Clinical Neurology

Cancer and Embolic Stroke of Undetermined Source

Babak B. Navi et al.

Summary: This study focuses on the characteristics, treatment strategies, and prognostic considerations of embolic stroke of undetermined source (ESUS) related to cancer in ischemic stroke patients. It suggests the need for subgrouping ESUS to better manage the disease.

STROKE (2021)

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Article Clinical Neurology

Advances in Understanding the Pathogenesis of Lacunar Stroke: From Pathology and Pathophysiology to Neuroimaging

Shuai Jiang et al.

Summary: Lacunar stroke, accounting for about one-quarter of all acute ischemic strokes, is an important marker of cerebral small vessel disease and has prognostic significance. Advanced imaging techniques, specifically high-resolution MRI, offer opportunities to understand the clinical mechanisms, imaging characteristics, and pathogenesis of LS.

CEREBROVASCULAR DISEASES (2021)

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Letter Cardiac & Cardiovascular Systems

2021 European Heart Rhythm Association Practical Guide on the use of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation: comment-Authors' reply

Michihiro Suwa et al.

EUROPACE (2021)

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Article Cardiac & Cardiovascular Systems

2021 ESC Guidelines on cardiovascular disease prevention in clinical practice Developed by the Task Force for cardiovascular disease prevention in clinical practice with representatives of the European Society of Cardiology and 12 medical societies With the special contribution of the European Association of Preventive Cardiology (EAPC)

Frank L. J. Visseren et al.

EUROPEAN HEART JOURNAL (2021)

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Review Clinical Neurology

Lacunar stroke: mechanisms and therapeutic implications

Shadi Yaghi et al.

Summary: Lacunar stroke is a heterogeneous disease with multiple mechanisms, necessitating careful evaluation of brain and neurovascular imaging, cardiac and systemic assessment. Improved understanding of pathomechanisms of neurological deterioration may lead to investigating novel treatment strategies and optimizing short-term antithrombotic treatment to reduce the risk of neurological deterioration and prevent long-term disability in patients with lacunar stroke.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2021)

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Review Clinical Neurology

2021 Guideline for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack: A Guideline From the American Heart Association/American Stroke Association

Dawn O. Kleindorfer et al.

Summary: Additional digital content is available in the text.

STROKE (2021)

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Article Clinical Neurology

European Stroke Organisation (ESO) guidelines on management of transient ischaemic attack

Ana Catarina Fonseca et al.

Summary: The aim of this study is to provide clinically useful guidelines for TIA management, particularly in triage, investigation and secondary prevention in the acute phase. Emphasis is placed on specialist review within 24 hours and the recommendation of using dual antiplatelet treatment.

EUROPEAN STROKE JOURNAL (2021)

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Article Clinical Neurology

European Stroke Organisation expedited recommendation for the use of short-term dual antiplatelet therapy early after minor stroke and high-risk TIA

Jesse Dawson et al.

Summary: It is strongly recommended to use aspirin and clopidogrel dual antiplatelet therapy for 21 days in patients with non-cardioembolic minor ischemic stroke or high-risk TIA in the past 24 hours, based on high quality evidence. It is weakly recommended to use aspirin and ticagrelor dual antiplatelet therapy for 30 days in patients with non-cardioembolic mild to moderate ischemic stroke or high-risk TIA in the past 24 hours, based on moderate quality evidence.

EUROPEAN STROKE JOURNAL (2021)

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Correction Clinical Neurology

Comparison of prasugrel and clopidogrel in patients with non-cardioernbolic ischaernic stroke: a phase 3, randomised, non-inferiority trial (PRASTRO-I) (vol 18, pg 238, 2019)

A. Ogawa et al.

LANCET NEUROLOGY (2020)

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Article Clinical Neurology

Association Between Low-Dose Rivaroxaban With or Without Aspirin and Ischemic Stroke Subtypes A Secondary Analysis of the COMPASS Trial

Kanjana S. Perera et al.

JAMA NEUROLOGY (2020)

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Article Clinical Neurology

Dabigatran Treatment of Acute Noncardioembolic Ischemic Stroke

Ken S. Butcher et al.

STROKE (2020)

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Review Clinical Neurology

Proposal for Updated Nomenclature and Classification of Potential Causative Mechanism in Patent Foramen Ovale-Associated Stroke

Akram Y. Elgendy et al.

JAMA NEUROLOGY (2020)

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Review Clinical Neurology

Cilostazol for Secondary Prevention of Stroke and Cognitive Decline Systematic Review and Meta-Analysis

Caroline McHutchison et al.

STROKE (2020)

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Article Medicine, General & Internal

Rivaroxaban in Patients with Atrial Fibrillation and a Bioprosthetic Mitral Valve

Helio P. Guimaraes et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Clinical Neurology

Safety and Efficacy of Prasugrel in Elderly/Low Body Weight Japanese Patients with Ischemic Stroke: Randomized PRASTRO-II

Kazuo Kitagawa et al.

CEREBROVASCULAR DISEASES (2020)

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Article Cardiac & Cardiovascular Systems

Efficacy and safety of apixaban vs warfarin in patients with atrial fibrillation and prior bioprosthetic valve replacement or valve repair: Insights from the ARISTOTLE trial

Patricia O. Guimaraes et al.

CLINICAL CARDIOLOGY (2019)

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Article Clinical Neurology

Antiplatelet Therapy vs Anticoagulation Therapy in Cervical Artery Dissection: The Cervical Artery Dissection in Stroke Study (CADISS) Randomized Clinical Trial Final Results

Hugh S. Markus et al.

JAMA NEUROLOGY (2019)

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Article Medicine, General & Internal

Dabigatran for Prevention of Stroke after Embolic Stroke of Undetermined Source

H. -C. Diener et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

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Review Clinical Neurology

Tailoring the Approach to Embolic Stroke of Undetermined Source A Review

Hooman Kamel et al.

JAMA NEUROLOGY (2019)

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Article Clinical Neurology

Dual antiplatelet therapy using cilostazol for secondary prevention in patients with high-risk ischaemic stroke in Japan: a multicentre, open-label, randomised controlled trial

Kazunori Toyoda et al.

LANCET NEUROLOGY (2019)

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Article Medicine, General & Internal

Ticagrelor plus aspirin versus clopidogrel plus aspirin for platelet reactivity in patients with minor stroke or transient ischaemic attack: open label, blinded endpoint, randomised controlled phase II trial

Yilong Wang et al.

BMJ-BRITISH MEDICAL JOURNAL (2019)

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Article Clinical Neurology

Outcomes Associated With Clopidogrel-Aspirin Use in Minor Stroke or Transient Ischemic Attack A Pooled Analysis of Clopidogrel in High-Risk Patients With Acute Non-Disabling Cerebrovascular Events (CHANCE) and Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trials

Yuesong Pan et al.

JAMA NEUROLOGY (2019)

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Article Clinical Neurology

Do Clinicians Overestimate the Severity of Intracerebral Hemorrhage?

Elliot J. Tilling et al.

STROKE (2019)

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Article Clinical Neurology

Comparison of prasugrel and clopidogrel in patients with non-cardioembolic ischaemic stroke: a phase 3, randomised, non-inferiority trial (PRASTRO-I)

Akira Ogawa et al.

LANCET NEUROLOGY (2019)

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Article Medicine, General & Internal

Tolerability, safety and intermediary pharmacological effects of cilostazol and isosorbide mononitrate, alone and combined, in patients with lacunar ischaemic stroke: The LACunar Intervention-1 (LACI-1) trial, a randomised clinical trial

Gordon W. Blair et al.

ECLINICALMEDICINE (2019)

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Article Cardiac & Cardiovascular Systems

Cryptogenic Stroke and High-Risk Patent Foramen Ovale The DEFENSE-PFO Trial

Pil Hyung Lee et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2018)

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Article Medicine, General & Internal

Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial

Philip M. Bath et al.

LANCET (2018)

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Article Medicine, General & Internal

Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA

S. Claiborne Johnston et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Article Medicine, General & Internal

Rivaroxaban for Stroke Prevention after Embolic Stroke of Undetermined Source

R. G. Hart et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Article Medicine, General & Internal

Rivaroxaban in Patients with Heart Failure, Sinus Rhythm, and Coronary Disease

Faiez Zannad et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Article Cardiac & Cardiovascular Systems

Long-term effectiveness and safety of transcatheter closure of patent foramen ovale compared with antithrombotic therapy alone: a meta-analysis of six randomised clinical trials and 3,560 patients with reconstructed time-to-event data

Daniele Giacoppo et al.

EUROINTERVENTION (2018)

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Article Clinical Neurology

Outcome of intracerebral hemorrhage associated with different oral anticoagulants

Duncan Wilson et al.

NEUROLOGY (2017)

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Article Medicine, General & Internal

Rivaroxaban with or without Aspirin in Stable Cardiovascular Disease

J. W. Eikelboom et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

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Article Medicine, General & Internal

Patent Foramen Ovale Closure or Antiplatelet Therapy for Cryptogenic Stroke

Lars Sondergaard et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

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Article Medicine, General & Internal

Long-Term Outcomes of Patent Foramen Ovale Closure or Medical Therapy after Stroke

Jeffrey L. Saver et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

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Article Medicine, General & Internal

Patent Foramen Ovale Closure or Anticoagulation vs. Antiplatelets after Stroke

J. -L. Mas et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

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Letter Cardiac & Cardiovascular Systems

Edoxaban for the Prevention of Thromboembolism in Patients With Atrial Fibrillation and Bioprosthetic Valves

Anthony P. Carnicelli et al.

CIRCULATION (2017)

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Article Medicine, General & Internal

Ticagrelor versus Aspirin in Acute Stroke or Transient Ischemic Attack

S. Claiborne Johnston et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

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Article Clinical Neurology

Recurrent Ischemic Lesions After Acute Atherothrombotic Stroke Clopidogrel Plus Aspirin Versus Aspirin Alone

Keun-Sik Hong et al.

STROKE (2016)

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Article Cardiac & Cardiovascular Systems

2015 ESC Guidelines for the management of infective endocarditis

Gilbert Habib et al.

EUROPEAN HEART JOURNAL (2015)

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Article Clinical Neurology

Clopidogrel plus aspirin versus aspirin alone for preventing early neurological deterioration in patients with acute ischemic stroke

Fan He et al.

JOURNAL OF CLINICAL NEUROSCIENCE (2015)

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Article Clinical Neurology

Efficacy of Antiplatelet Therapy in Secondary Prevention Following Lacunar Stroke Pooled Analysis of Randomized Trials

Chun Shing Kwok et al.

STROKE (2015)

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Article Clinical Neurology

Recurrent Stroke in the Warfarin versus Aspirin in Reduced Cardiac Ejection Fraction (WARCEF) Trial

Patrick M. Pullicino et al.

CEREBROVASCULAR DISEASES (2014)

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Article Clinical Neurology

Dipyridamole-induced headache and lower recurrence risk in secondary prevention of ischaemic stroke: a post hoc analysis

G. Davidai et al.

EUROPEAN JOURNAL OF NEUROLOGY (2014)

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Article Neurosciences

A Comparative Study of Dual versus Monoantiplatelet Therapy in Patients with Acute Large-Artery Atherosclerosis Stroke

Xingyang Yi et al.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2014)

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Article Cardiac & Cardiovascular Systems

Prospective Randomized Evaluation of the Watchman Left Atrial Appendage Closure Device in Patients With Atrial Fibrillation Versus Long-Term Warfarin Therapy

David R. Holmes et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2014)

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Article Medicine, General & Internal

Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials

Christian T. Ruff et al.

LANCET (2014)

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Article Clinical Neurology

Embolic strokes of undetermined source: the case for a new clinical construct

Robert G. Hart et al.

LANCET NEUROLOGY (2014)

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Article Cardiac & Cardiovascular Systems

Neurological Complications of Infective Endocarditis: Risk Factors, Outcome, and Impact of Cardiac Surgery: A Multicenter Observational Study

Emilio Garcia-Cabrera et al.

CIRCULATION (2013)

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Article Radiology, Nuclear Medicine & Medical Imaging

18F-FDG PET/CT diagnosis of unexpected extracardiac septic embolisms in patients with suspected cardiac endocarditis

Rachele Bonfiglioli et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2013)

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Article Clinical Neurology

Effect of Cilostazol in Acute Lacunar Infarction Based on Pulsatility Index of Transcranial Doppler (ECLIPse): A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial

Sang Won Han et al.

EUROPEAN NEUROLOGY (2013)

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Article Clinical Neurology

An index to identify stroke-related vs incidental patent foramen ovale in cryptogenic stroke

David M. Kent et al.

NEUROLOGY (2013)

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Article Medicine, General & Internal

Clopidogrel with Aspirin in Acute Minor Stroke or Transient Ischemic Attack

Yongjun Wang et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

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Article Medicine, General & Internal

Closure of Patent Foramen Ovale versus Medical Therapy after Cryptogenic Stroke

John D. Carroll et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

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Article Medicine, General & Internal

Dabigatran versus Warfarin in Patients with Mechanical Heart Valves

John W. Eikelboom et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

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Article Medicine, General & Internal

Percutaneous Closure of Patent Foramen Ovale in Cryptogenic Embolism

Bernhard Meier et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

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Article Medicine, General & Internal

Edoxaban versus Warfarin in Patients with Atrial Fibrillation

Robert P. Giugliano et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

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Article Clinical Neurology

Clopidogrel Added to Aspirin Adds No Benefit but Bleeding Risk in Patients With Recent Lacunar Stroke

Hans-Christoph Diener et al.

STROKE (2013)

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Article Clinical Neurology

Cilostazol combined with aspirin prevents early neurological deterioration in patients with acute ischemic stroke: A pilot study

Tomomi Nakamura et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2012)

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Editorial Material Medicine, General & Internal

Does cardiac insufficiency receive AVK?

Helene Vaillant-Roussel et al.

EXERCER-LA REVUE FRANCOPHONE DE MEDECINE GENERALE (2012)

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Article Medicine, General & Internal

Effects of Clopidogrel Added to Aspirin in Patients with Recent Lacunar Stroke

Oscar R. Benavente et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

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Article Medicine, General & Internal

Closure or Medical Therapy for Cryptogenic Stroke with Patent Foramen Ovale

Anthony J. Furlan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

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Article Medicine, General & Internal

Warfarin and Aspirin in Patients with Heart Failure and Sinus Rhythm

Shunichi Homma et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

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Article Cardiac & Cardiovascular Systems

Declining Stroke and Vascular Event Recurrence Rates in Secondary Prevention Trials Over the Past 50 Years and Consequences for Current Trial Design

Keun-Sik Hong et al.

CIRCULATION (2011)

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Article Infectious Diseases

Warfarin therapy and incidence of cerebrovascular complications in left-sided native valve endocarditis

U. Snygg-Martin et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2011)

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Article Medicine, General & Internal

Stenting versus Aggressive Medical Therapy for Intracranial Arterial Stenosis

Marc I. Chimowitz et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

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Article Medicine, General & Internal

Apixaban in Patients with Atrial Fibrillation

Stuart J. Connolly et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

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Article Medicine, General & Internal

Apixaban versus Warfarin in Patients with Atrial Fibrillation

Christopher B. Granger et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

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Article Medicine, General & Internal

Rivaroxaban versus Warfarin in Nonvalvular Atrial Fibrillation

Manesh R. Patel et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

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Article Clinical Neurology

Efficacy and Safety of Combination Antiplatelet Therapies in Patients With Symptomatic Intracranial Atherosclerotic Stenosis

Sun U. Kwon et al.

STROKE (2011)

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Article Clinical Neurology

Clopidogrel plus aspirin versus aspirin alone for reducing embolisation in patients with acute symptomatic cerebral or carotid artery stenosis (CLAIR study): a randomised, open-label, blinded-endpoint trial

Ka Sing Lawrence Wong et al.

LANCET NEUROLOGY (2010)

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Article Clinical Neurology

Cilostazol for prevention of secondary stroke (CSPS 2): an aspirin-controlled, double-blind, randomised non-inferiority trial

Yukito Shinohara et al.

LANCET NEUROLOGY (2010)

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Article Medicine, General & Internal

Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation: a randomised non-inferiority trial

David R. Holmes et al.

LANCET (2009)

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Article Medicine, General & Internal

Dabigatran versus Warfarin in Patients with Atrial Fibrillation.

Stuart J. Connolly et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

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Article Medicine, General & Internal

Effect of Clopidogrel Added to Aspirin in Patients with Atrial Fibrillation

S. J. Connolly et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

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Review Clinical Neurology

Extracranial carotid and vertebral artery dissection: A review

Gary John Redekop

CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES (2008)

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Article Medicine, General & Internal

Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke

Ralph L. Sacco et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

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Article Clinical Neurology

Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomised controlled pilot trial

James Kennedy et al.

LANCET NEUROLOGY (2007)

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Article Clinical Neurology

Medium intensity oral anticoagulants versus aspirin after cerebral ischaemia of arterial origin (ESPRIT): a randomised controlled trial

P. H. A. Halkes et al.

LANCET NEUROLOGY (2007)

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Review Cardiac & Cardiovascular Systems

ACCF/SCAI/SVMB/SIR/ASITN 2007 clinical expert consensus document on carotid stenting - A report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents (ACCF/SCAI/SVMB/SIR/ASITN Clinical Expert Consensus Document Committee on Carotid Stenting)

Eric R. Bates et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2007)

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Article Medicine, General & Internal

Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial

S. Connolly et al.

LANCET (2006)

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Article Medicine, General & Internal

Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events

DL Bhatt et al.

NEW ENGLAND JOURNAL OF MEDICINE (2006)

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Article Clinical Neurology

Aspirin or anticoagulants in stenosis of the middle cerebral artery: A randomized trial

J. Marti-Fabregas et al.

CEREBROVASCULAR DISEASES (2006)

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Article Medicine, General & Internal

Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosis

MI Chimowitz et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

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Article Clinical Neurology

Benefit of clopidogrel over aspirin is amplified in patients with a history of ischemic events

PA Ringleb et al.

STROKE (2004)

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Article Medicine, General & Internal

Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial

HC Diener et al.

LANCET (2004)

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Article Cardiac & Cardiovascular Systems

A randomized trial of aspirin on the risk of embolic events in patients with infective endocarditis

KL Chan et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2003)

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Article Medicine, General & Internal

A comparison of warfarin and aspirin for the prevention of recurrent ischemic stroke

JP Mohr et al.

NEW ENGLAND JOURNAL OF MEDICINE (2001)

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Article Clinical Neurology

Indications for early aspirin use in acute ischemic stroke - A combined analysis of 40 000 randomized patients from the Chinese Acute Stroke Trial and the International Stroke Trial

ZM Chen et al.

STROKE (2000)

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Article Clinical Neurology

Ischemic stroke subtypes - A population-based study of functional outcome, survival, and recurrence

GW Petty et al.

STROKE (2000)

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Article Cardiac & Cardiovascular Systems

Early and long-term (one-year) effects of the association of aspirin and oral anticoagulant on thrombi and morbidity after replacement of the mitral valve with the St. Jude medical prosthesis - A clinical and transesophageal echocardiographic study

P Laffort et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2000)

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