☆ 4.7 Article

Impact of Geroscience on Therapeutic Strategies for Older Adults With Cardiovascular Disease

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2023)

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Weiqi Zhang et al.

CIRCULATION RESEARCH (2018)

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Editorial Material Medicine, General & Internal

Aging as a Biological Target for Prevention and Therapy

Nir Barzilai et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2018)

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Review Cardiac & Cardiovascular Systems

Telomere Length as Cardiovascular Aging Biomarker JACC Review Topic of the Week

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JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2018)

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Review Cardiac & Cardiovascular Systems

Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty

Luigi Ferrucci et al.

NATURE REVIEWS CARDIOLOGY (2018)

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Review Geriatrics & Gerontology

A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup

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GEROSCIENCE (2018)

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Review Cardiac & Cardiovascular Systems

Development of clinical trials to extend healthy lifespan

Jamie N. Justice et al.

CARDIOVASCULAR ENDOCRINOLOGY & METABOLISM (2018)

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Article Physiology

The murine dialysis fistula model exhibits a senescence phenotype: pathobiological mechanisms and therapeutic potential

Karl A. Nath et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2018)

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Article Medicine, General & Internal

Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial

Paul M. Ridker et al.

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Article Medicine, General & Internal

Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes

Bruce Neal et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

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Article Medicine, General & Internal

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

P. M. Ridker et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

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Article Multidisciplinary Sciences

Caloric restriction improves health and survival of rhesus monkeys

Julie A. Mattison et al.

NATURE COMMUNICATIONS (2017)

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Article Medicine, General & Internal

Inequalities in Life Expectancy Among US Counties, 1980 to 2014 Temporal Trends and Key Drivers

Laura Dwyer-Lindgren et al.

JAMA INTERNAL MEDICINE (2017)

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Article Endocrinology & Metabolism

Effects of acarbose on cardiovascular and diabetes outcomes in patients with coronary heart disease and impaired glucose tolerance (ACE): a randomised, double-blind, placebo-controlled trial

Rury R. Holman et al.

LANCET DIABETES & ENDOCRINOLOGY (2017)

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Article Geriatrics & Gerontology

A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs

Silvan R. Urfer et al.

GEROSCIENCE (2017)

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Review Cell Biology

Metformin reduces all-cause mortality and diseases of ageing independent of its effect on diabetes control: A systematic review and meta-analysis

Jared M. Campbell et al.

AGEING RESEARCH REVIEWS (2017)

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Article Cell Biology

Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice

John C. Newman et al.

CELL METABOLISM (2017)

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Review Cardiac & Cardiovascular Systems

Molecular effects of exercise training in patients with cardiovascular disease: focus on skeletal muscle, endothelium, and myocardium

Volker Adams et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2017)

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Article Cell Biology

New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463

Yi Zhu et al.

AGING-US (2017)

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Review Medicine, General & Internal

Clinical Outcomes of Metformin Use in Populations With Chronic Kidney Disease, Congestive Heart Failure, or Chronic Liver Disease A Systematic Review

Matthew J. Crowley et al.

ANNALS OF INTERNAL MEDICINE (2017)

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Article Cell Biology

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an -glucosidase inhibitor or a Nrf2-inducer

Randy Strong et al.

AGING CELL (2016)

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Article Cell Biology

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

Carolyn M. Roos et al.

AGING CELL (2016)

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Article Cell Biology

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

Yi Zhu et al.

AGING CELL (2016)

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Article Cardiac & Cardiovascular Systems

Histone acetylation and methylation significantly change with severity of atherosclerosis in human carotid plaques

Anna Greissel et al.

CARDIOVASCULAR PATHOLOGY (2016)

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Review Cell Biology

Exercise Promotes Healthy Aging of Skeletal Muscle

Gregory D. Cartee et al.

CELL METABOLISM (2016)

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Review Cell Biology

The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging

Brian K. Kennedy et al.

CELL METABOLISM (2016)

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Article Medicine, General & Internal

Effect of Caloric Restriction or Aerobic Exercise Training on Peak Oxygen Consumption and Quality of Life in Obese Older Patients With Heart Failure With Preserved Ejection Fraction A Randomized Clinical Trial

Dalane W. Kitzman et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2016)

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Article Geriatrics & Gerontology

Frameworks for Proof-of-Concept Clinical Trials of Interventions That Target Fundamental Aging Processes

Jamie Justice et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2016)

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Article Geriatrics & Gerontology

Strategies and Challenges in Clinical Trials Targeting Human Aging

John C. Newman et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2016)

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Article Medicine, General & Internal

Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes

Steven P. Marso et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

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Article Medicine, General & Internal

Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes

Steven P. Marso et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

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Review Nutrition & Dietetics

Effects of dietary protein intake on body composition changes after weight loss in older adults: a systematic review and meta-analysis

Jung Eun Kim et al.

NUTRITION REVIEWS (2016)

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Article Multidisciplinary Sciences

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

Bennett G. Childs et al.

SCIENCE (2016)

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Article Cell Biology

The Achilles' heel of senescent cells: from transcriptome to senolytic drugs

Yi Zhu et al.

AGING CELL (2015)

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Review Cell Biology

Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits

P. Darrell Neufer et al.

CELL METABOLISM (2015)

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Article Multidisciplinary Sciences

Intentional Weight Loss and All-Cause Mortality: A Meta-Analysis of Randomized Clinical Trials

Stephen B. Kritchevsky et al.

PLOS ONE (2015)

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Review Geriatrics & Gerontology

Prevalence of and interventions for sarcopenia in ageing adults: a systematic review. Report of the International Sarcopenia Initiative (EWGSOP and IWGS)

Alfonso J. Cruz-Jentoft et al.

AGE AND AGEING (2014)

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Article Cell Biology

Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

David E. Harrison et al.

AGING CELL (2014)

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Article Cell Biology

Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

Richard A. Miller et al.

AGING CELL (2014)

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Article Oncology

Metformin and Cancer Risk and Mortality: A Systematic Review and Meta-analysis Taking into Account Biases and Confounders

Sara Gandini et al.

CANCER PREVENTION RESEARCH (2014)

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Article Cardiac & Cardiovascular Systems

Frailty Assessment in the Cardiovascular Care of Older Adults

Jonathan Afilalo et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2014)

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Article Geriatrics & Gerontology

Simple Biologically Informed Inflammatory Index of Two Serum Cytokines Predicts 10 Year All-Cause Mortality in Older Adults

Ravi Varadhan et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2014)

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Review Cell Biology

Cellular senescence: from physiology to pathology

Daniel Munoz-Espin et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

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Article Medicine, Research & Experimental

Resveratrol in primary and secondary prevention of cardiovascular disease: a dietary and clinical perspective

Joao Tome-Carneiro et al.

RESVERATROL AND HEALTH (2013)

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Review Biochemistry & Molecular Biology

The Hallmarks of Aging

Carlos Lopez-Otin et al.

CELL (2013)

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Article Cell Biology

Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging

Yun-Hee Youm et al.

CELL METABOLISM (2013)

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Article Biochemistry & Molecular Biology

Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates

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MOLECULAR CELL (2013)

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Article Biotechnology & Applied Microbiology

DNA methylation age of human tissues and cell types

Steve Horvath

GENOME BIOLOGY (2013)

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Review Cell Biology

AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network

Antero Salminen et al.

AGEING RESEARCH REVIEWS (2012)

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Article Nutrition & Dietetics

A moderate acute increase in physical activity enhances nutritive flow and the muscle protein anabolic response to mixed nutrient intake in older adults

Kyle L. Timmerman et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2012)

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Article Cardiac & Cardiovascular Systems

Nucleotide Excision DNA Repair Is Associated With Age-Related Vascular Dysfunction

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CIRCULATION (2012)

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Review Cardiac & Cardiovascular Systems

Mitochondria and Cardiovascular Aging

Dao-Fu Dai et al.

CIRCULATION RESEARCH (2012)

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Review Cardiac & Cardiovascular Systems

Telomeres and Mitochondria in the Aging Heart

Javid Moslehi et al.

CIRCULATION RESEARCH (2012)

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Article Clinical Neurology

PAX7+ satellite cells in young and older adults following resistance exercise

Dillon K. Walker et al.

MUSCLE & NERVE (2012)

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Article Cell Biology

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

Jun Yoshino et al.

CELL METABOLISM (2011)

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Article Cardiac & Cardiovascular Systems

Cardiac Care for Older Adults Time for a New Paradigm

Daniel E. Forman et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2011)

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Review Clinical Neurology

Mortality trends in the general population: the importance of cardiorespiratory fitness

Duck-chul Lee et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2010)

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Article Endocrinology & Metabolism

Body Fat Distribution and Inflammation Among Obese Older Adults With and Without Metabolic Syndrome

Annemarie Koster et al.

OBESITY (2010)

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Article Nutrition & Dietetics

Physiologic and molecular bases of muscle hypertrophy and atrophy: impact of resistance exercise on human skeletal muscle (protein and exercise dose effects)

Stuart M. Phillips

APPLIED PHYSIOLOGY NUTRITION AND METABOLISM (2009)

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Review Biochemistry & Molecular Biology

Epigenetics and atherosclerosis

Mikko P. Turunen et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2009)

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

David E. Harrison et al.

NATURE (2009)

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Article Geriatrics & Gerontology

A standard procedure for creating a frailty index

Samuel D Searle et al.

BMC Geriatrics (2008)

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Article Endocrinology & Metabolism

Aerobic exercise overcomes the age-related insulin resistance of muscle protein metabolism by improving endothelial function and Akt/mammalian target of rapamycin signaling

Satoshi Fujita et al.

DIABETES (2007)

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Review Cardiac & Cardiovascular Systems

Vascular cell senescence - Contribution to atherosclerosis

Tohru Minamino et al.

CIRCULATION RESEARCH (2007)

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Article Cardiac & Cardiovascular Systems

Induction of heat shock response protects the heart against atrial fibrillation

Bianca J. J. M. Brundel et al.

CIRCULATION RESEARCH (2006)

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Article Multidisciplinary Sciences

Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients

M Kaeberlein et al.

SCIENCE (2005)

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Article Medicine, General & Internal

Acarbose for prevention of type 2 diabetes mellitus: the STOPNIDDM randomised trial

JL Chiasson et al.

LANCET (2002)

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Article Geriatrics & Gerontology

Frailty in older adults: Evidence for a phenotype

LP Fried et al.

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