4.8 Article

Nanoscale Metal-Organic Framework with an X-ray Triggerable Prodrug for Synergistic Radiotherapy and Chemotherapy

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Multidisciplinary

Metal-Organic Layer Delivers 5-Aminolevulinic Acid and Porphyrin for Dual-Organelle-Targeted Photodynamic Therapy

Taokun Luo et al.

Summary: A dual-organelle-targeted nanoparticle platform was developed for enhanced photodynamic therapy (PDT) of cancer. The platform grafted 5-aminolevulinic acid (ALA) to a Hf-12-based nanoscale metal-organic layer (Hf-MOL), which improved ALA delivery and protoporphyrin IX (PpIX) synthesis in mitochondria, and trapped 5,15-di-p-benzoatoporphyrin (DBP) photosensitizers in lysosomes. By simultaneously exciting PpIX and DBP with light irradiation at 630 nm, synergistic enhancement of PDT efficacy was achieved through the damage to both mitochondria and lysosomes.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2023)

Article Chemistry, Multidisciplinary

Radiation-Responsive Benzothiazolines as Potential Cleavable Fluorogenic Linkers for Drug Delivery

Wei Tuo et al.

Summary: This study presents the use of benzothiazolines as radiosensitive compounds that can produce gamma-irradiation and fluorescent benzothiazoles, as well as release amines or carboxylic acids upon treatment with Cs-137 in water. The proof of concept study demonstrated that benzothiazolines can be utilized as cleavable linkers that are triggered by irradiation.

CHEMISTRY-A EUROPEAN JOURNAL (2023)

Article Chemistry, Multidisciplinary

Carboxylated paclitaxel prodrug nanofibers for enhanced chemotherapy

Shaojin Lu et al.

Summary: The challenge of easily obtaining nanoformulations with improved antitumor performance is addressed by synthesizing amphiphilic paclitaxel prodrugs capable of robust assembly. Carboxylated paclitaxel prodrugs (PSCB) with disulfide bonds form intricate nanofibers, while phenylcarbinol end capped paclitaxel prodrugs (PSP) assemble into spherical nanoparticles. Morphology transformation from nanofibers to nanorods is achieved by adjusting the paclitaxel content. Hydrophilic domains of PSCB nanofibers facilitate the cleavage of disulfide bonds for rapid drug release in tumor cells, resulting in enhanced cytotoxicity and antitumor activity. This study provides crucial insights into the functional design of hydrophobic drugs for improved chemotherapy.

JOURNAL OF CONTROLLED RELEASE (2023)

Article Chemistry, Multidisciplinary

Metal coordination micelles for anti-cancer treatment by gene-editing and phototherapy

Chen Zhang et al.

Summary: This study developed a new biomaterial called Ce6-Mn-Cas9, which loaded Cas9 onto chlorin-e6 (Ce6) manganese (Mn) coordination micelles for combined anti-cancer treatment. Manganese played multiple roles in facilitating delivery, Fenton-like effect, and enhancing endonuclease activity of Cas9. Ce6-Mn-Cas9 released Cas9 triggered by ATP and endolysosomal acidic pH without altering protein structure or function. In a murine tumor model, Ce6-Mn-Cas9 inhibited tumor growth with the combination therapy of photodynamic therapy and gene editing. Ce6-Mn-Cas9 represents a versatile biomaterial for photo and gene therapy approaches.

JOURNAL OF CONTROLLED RELEASE (2023)

Review Chemistry, Multidisciplinary

Nanoparticle-Mediated Radiotherapy Remodels the Tumor Microenvironment to Enhance Antitumor Efficacy

Wenyao Zhen et al.

Summary: Radiotherapy uses ionizing radiation to eliminate localized tumors and occasionally control tumors outside the treated area via the abscopal effect. However, it is often limited by physiological barriers in the tumor microenvironment, such as hypoxia, abnormal blood vessels, dense extracellular matrix, and immunosuppression. Therefore, it is crucial to develop new radiotherapy strategies that can remodel the tumor microenvironment to overcome radiation resistance and immune suppression.

ADVANCED MATERIALS (2023)

Article Engineering, Biomedical

Recent development of metal-organic framework nanocomposites for biomedical applications

Xueying Ge et al.

Summary: Reducing the size of metal-organic framework (MOF) composites to the nanoscale has presented unique opportunities for enhanced properties. MOF-based nanocomposites offer limitless possibilities for biomedical applications. This review focuses on the recent development, classification, and construction methods of MOF-based nanocomposites for biomedical applications.

BIOMATERIALS (2022)

Article Chemistry, Multidisciplinary

Radiotherapy Reduces N-Oxides for Prodrug Activation in Tumors

Zexuan Ding et al.

Summary: This article introduces a novel strategy of using radiotherapy to activate prodrugs for chemotherapy. The reduction of N-oxides by hydrated electrons generated from radiation is demonstrated to be effective, and the activation of N-oxide prodrugs shows remarkable anticancer effects.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

Article Engineering, Biomedical

Targeted Delivery of DNA Topoisomerase Inhibitor SN38 to Intracranial Tumors of Glioblastoma Using Sub-5 Ultrafine Iron Oxide Nanoparticles

Yuancheng Li et al.

Summary: Delivering therapeutics for brain tumors is challenging due to the barriers in the brain. This study investigates the use of ultrafine iron oxide nanoparticles as carriers for delivering a DNA topoisomerase inhibitor to treat glioblastoma. The nanoparticles show high drug loading efficiency and pH-sensitive drug release, protecting the drug from inactivation. Targeted therapy using these nanoparticles demonstrates cytotoxicity to glioblastoma cells. Animal experiments show tumor-specific delivery and improved survival rates with the nanoparticle treatment.

ADVANCED HEALTHCARE MATERIALS (2022)

Article Chemistry, Multidisciplinary

Radiotherapy-Triggered Proteolysis Targeting Chimera Prodrug Activation in Tumors

Chunrong Yang et al.

Summary: Proteolysis targeting chimera (PROTAC) is an emerging protein degradation strategy that shows great potential in targeting difficult-to-drug proteins. This study introduces a radiotherapy-triggered PROTAC prodrug (RT-PROTAC) activation strategy for precise and spatiotemporal control of protein degradation through X-ray radiation. The activated RT-PROTAC effectively degrades target proteins and exhibits synergistic anticancer activity with radiotherapy. This research provides an alternative approach for controlling protein degradation in vivo, offering a potential solution to minimize the systemic toxicity of PROTACs.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

Article Chemistry, Multidisciplinary

A 2D Nanoradiosensitizer Enhances Radiotherapy and Delivers STING Agonists to Potentiate Cancer Immunotherapy

Taokun Luo et al.

Summary: This study reports a novel nanoplatform, cGAMP/MOL, that can simultaneously activate STING and enhance radiosensitization. By improving the delivery of STING agonists and combining with an immune checkpoint inhibitor, it can effectively enhance anti-tumor efficacy.

ADVANCED MATERIALS (2022)

Article Chemistry, Multidisciplinary

Radiotherapy-Induced Cleavage of Quaternary Ammonium Groups Activates Prodrugs in Tumors

Zhibin Guo et al.

Summary: Cleavage chemistry enables controlled drug release in tumors. Researchers achieved drug release and treatment in living cells and mice through radiotherapy-induced cleavage chemistry.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

Article Biochemical Research Methods

Radiation Cleaved Drug-Conjugate Linkers Enable Local Payload Release

Jeremy M. Quintana et al.

Summary: Conjugating therapeutic payloads to biologics can improve drug delivery to tumors, but also poses a risk of toxicity in off-target tissues. This study presents a novel drug-conjugate linker strategy that releases active drugs upon exposure to ionizing radiation, resulting in localized cancer drug delivery.

BIOCONJUGATE CHEMISTRY (2022)

Article Chemistry, Multidisciplinary

Hypoxia-Activated PEGylated Paclitaxel Prodrug Nanoparticles for Potentiated Chemotherapy

Dengyuan Hao et al.

Summary: Developing controlled drug-release systems is crucial for increasing therapeutic efficacy. In this study, we synthesized hypoxia-responsive PEGylated paclitaxel prodrugs, which could release the drug and exert cytotoxicity in the tumor hypoxia microenvironment.

ACS NANO (2022)

Article Chemistry, Organic

Ligand release from silicon phthalocyanine dyes triggered by X-ray irradiation

Hideo Takakura et al.

Summary: Ligand release from SiPc dyes can be triggered by X-ray irradiation, and the cleavage of axial ligands occurs through reactions with hydrated electrons generated from water.

ORGANIC & BIOMOLECULAR CHEMISTRY (2022)

Article Nanoscience & Nanotechnology

Engineering Paclitaxel Prodrug Nanoparticles via Redox-Activatable Linkage and Effective Carriers for Enhanced Chemotherapy

Shaojin Lu et al.

Summary: The clinical performance of chemotherapy is unsatisfactory due to limited delivery efficacy and systemic side effects. Dimeric prodrug systems show promise in enhancing antitumor outcomes, with dimeric paclitaxel prodrug nanoparticles achieving selective cytotoxicity against tumor cells. The optimal carrier materials have been identified for stability, endocytosis, cytotoxicity, biodistribution, and antitumor efficacy.

ACS APPLIED MATERIALS & INTERFACES (2021)

Article Chemistry, Multidisciplinary

Ultrasound Controlled Anti-Inflammatory Polarization of Platelet Decorated Microglia for Targeted Ischemic Stroke Therapy

Yujie Li et al.

Summary: The study developed a platelet hybrid microglia platform that can polarize to the anti-inflammatory phenotype specifically by ultrasound irradiation for targeted cerebrum repair after stroke, showing promising prospects for stroke therapy.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Article Chemistry, Multidisciplinary

Monte Carlo Simulations Reveal New Design Principles for Efficient Nanoradiosensitizers Based on Nanoscale Metal-Organic Frameworks

Ziwan Xu et al.

Summary: The study conducted Monte Carlo simulations to compare radiosensitization effects of nanoscale metal-organic frameworks (nMOFs) with solid nanoparticles (NPs) under X-ray excitation. The results showed that lattices formed by nanoscale secondary building units (SBUs) outperformed solid NPs in enhancing scatterings of photons and electrons within the lattices, regardless of radiation sources or particle sizes. Optimum dose enhancement was achieved by tuning SBU size and inter-SBU distance.

ADVANCED MATERIALS (2021)

Article Chemistry, Multidisciplinary

Light-Triggered Release of Large Biomacromolecules from Porphyrin-Phospholipid Liposomes

Hailey Kilian et al.

Summary: This study demonstrates the feasibility of light-triggered release of large biomacromolecules from liposomes. Liposomes containing PoP can release small to large molecules upon exposure to red light, showing a size-dependent manner that is associated with the oxidation of unsaturated lipids in the bilayer.

LANGMUIR (2021)

Article Chemistry, Multidisciplinary

Neutrophil Delivered Hollow Titania Covered Persistent Luminescent Nanosensitizer for Ultrosound Augmented Chemo/Immuno Glioblastoma Therapy

Yujie Li et al.

Summary: An ultrasound augmented chemo/immuno therapy for GBM using a neutrophil-delivered nanosensitizer has been developed, which enhances the survival rate of GBM bearing mice and provides long-term immuno-surveillance for tumor recurrence. This new approach involves ROS generation from the sensitizer and liposome destruction for drug release to kill tumors and induce local inflammation.

ADVANCED SCIENCE (2021)

Article Medicine, Research & Experimental

A tumor microenvironment responsive nanosystem for chemodynamic/chemical synergistic theranostics of colorectal cancer

Liying Wang et al.

Summary: This study presents a tumor microenvironment-responsive nanosystem for chemodynamic/chemical synergistic therapy and magnetic resonance imaging. The nanosystem improves the cycling time and solubility of chemotherapeutic drugs, releasing them gradually in tumor tissues through glutathione-triggered biodegradation. With improved generation of reactive oxygen species and controlled release of the chemotherapeutic drug, it shows excellent inhibition of tumor growth in colorectal cancer models.

THERANOSTICS (2021)

Article Nanoscience & Nanotechnology

Design of a Thiol-Responsive, Traceless Prodrug with Rapid Self-Immolation for Cancer Chemotherapy

Gengqi Liu et al.

Summary: The study introduces a new strategy to generate self-immolative prodrugs that can release pristine active pharmaceutical ingredients in tumors, showing enhanced cellular uptake and anticancer efficacy.

ACS APPLIED BIO MATERIALS (2021)

Review Chemistry, Multidisciplinary

Stimuli-responsive metal-organic framework nanoparticles for controlled drug delivery and medical applications

Zhixin Zhou et al.

Summary: Stimuli-responsive metal-organic framework nanoparticles, NMOFs, offer a versatile platform for controlled drug release and biomedical applications. Various triggers, such as chemical, physical, and biomarkers, can be used to unlock the loaded NMOFs and release the drugs, showing great potential for therapeutic applications in cancer treatment, anti-blood clotting, and artificial pancreas design.

CHEMICAL SOCIETY REVIEWS (2021)

Review Engineering, Biomedical

Metal-organic frameworks for stimuli-responsive drug delivery

Ying Wang et al.

BIOMATERIALS (2020)

Review Chemistry, Multidisciplinary

Metal-Organic Frameworks for Biomedical Applications

Jie Yang et al.

Review Nanoscience & Nanotechnology

Metal-Organic Framework Nanocarriers for Drug Delivery in Biomedical Applications

Yujia Sun et al.

NANO-MICRO LETTERS (2020)

Article Chemistry, Multidisciplinary

External-Radiation-Induced Local Hydroxylation Enables Remote Release of Functional Molecules in Tumors

Qunfeng Fu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Article Chemistry, Multidisciplinary

Facile and reversible digestion and regeneration of zirconium-based metal-organic frameworks

Jun Chu et al.

COMMUNICATIONS CHEMISTRY (2020)

Article Multidisciplinary Sciences

Nanoscale metal-organic frameworks enhance radiotherapy to potentiate checkpoint blockade immunotherapy

Kaiyuan Ni et al.

NATURE COMMUNICATIONS (2018)

Article Chemistry, Multidisciplinary

Temperature Treatment of Highly Porous Zirconium-Containing Metal-Organic Frameworks Extends Drug Delivery Release

Michelle H. Teplerisky et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

Meeting Abstract Oncology

Histone demethyalase JMJD1A promotes the DNA damage response of prostate cancer cells

Lingling Fan et al.

CANCER RESEARCH (2016)

Article Engineering, Biomedical

Endocytosis Mechanism of Nano Metal-Organic Frameworks for Drug Delivery

Claudia Orellana-Tavra et al.

ADVANCED HEALTHCARE MATERIALS (2016)

Article Materials Science, Biomaterials

Drug delivery and controlled release from biocompatible metal-organic frameworks using mechanical amorphizationt

Claudia Orellana-Tavra et al.

JOURNAL OF MATERIALS CHEMISTRY B (2016)

Article Chemistry, Multidisciplinary

Amorphous metal-organic frameworks for drug delivery

Claudia Orellana-Tavra et al.

CHEMICAL COMMUNICATIONS (2015)

Article Chemistry, Multidisciplinary

Nucleic Acid-Metal Organic Framework (MOF) Nanoparticle Conjugates

William Morris et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

Review Chemistry, Multidisciplinary

Metal-Organic Frameworks in Biomedicine

Patricia Horcajada et al.

CHEMICAL REVIEWS (2012)

Article Chemistry, Multidisciplinary

Chiral Nanoporous Metal-Organic Frameworks with High Porosity as Materials for Drug Delivery

Chun-Yi Sun et al.

ADVANCED MATERIALS (2011)

Review Chemistry, Multidisciplinary

BioMOFs: Metal-Organic Frameworks for Biological and Medical Applications

Alistair C. McKinlay et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)

Article Chemistry, Medicinal

Calculation of Effective Penetration Depth in X-Ray Diffraction for Pharmaceutical Solids

Jodi Liu et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2010)

Article Chemistry, Multidisciplinary

Flexible porous metal-organic frameworks for a controlled drug delivery

Patricia Horcajada et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)

Review Oncology

Innovations in image-guided radiotherapy

Dirk Verellen et al.

NATURE REVIEWS CANCER (2007)

Review Oncology

Image-guided radiotherapy: rationale, benefits, and limitations

Laura A. Dawson et al.

LANCET ONCOLOGY (2006)