Peptide/Nanoparticle Biointerfaces for Multistep Tandem Catalysis

Therealization of multifunctional nanoparticle systems is essentialto achieve highly efficient catalytic materials for specific applications;however, their production remains quite challenging. They are typicallyachieved through the incorporation of multiple inorganic components;however, incorporation of functionality could also be achieved atthe organic ligand layer. In this work, we demonstrate the generationof multifunctional nanoparticle catalysts using peptide-based ligandsfor tandem catalytic functionality. To this end, chimeric peptideswere designed that incorporated a Au binding sequence and a catalyticsequence that can drive ester hydrolysis. Using this chimera, Au nanoparticleswere prepared, which sufficiently presented the catalytic domain ofthe peptide to drive tandem catalytic processes occurring at the peptideligand layer and the Au nanoparticle surface. This work representsunique pathways to achieve multifunctionality from nanoparticle systemstuned by both the inorganic and bio/organic components, which couldbe highly important for applications beyond catalysis, including theranostics,sensing, and energy technologies.

Automated summary

The realization of multifunctional nanoparticle systems is crucial for highly efficient catalytic materials in specific applications, but their production remains challenging. While typically achieved through incorporating multiple inorganic components, functionality can also be achieved at the organic ligand layer. In this work, peptide-based ligands were used to generate multifunctional nanoparticle catalysts for tandem catalytic functionality. This study provides a unique pathway to achieve multifunctionality in nanoparticle systems through the incorporation of inorganic and bio/organic components, with potential implications for applications beyond catalysis in areas such as theranostics, sensing, and energy technologies.