☆ 4.8 Article

Constructing Antiretroviral Supramolecular Polymers as Long-Acting Injectables through Rational Design of Drug Amphiphiles with Alternating Antiretroviral-Based and Hydrophobic Residues

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Chemistry, Multidisciplinary

Enzyme-Instructed Peptide Assembly Favored by Preorganization for Cancer Cell Membrane Engineering

Yinghao Ding et al.

Summary: An enzyme-instructed peptide self-assembly (EISA) strategy is used to selectively modify cancer cell membranes, and different phosphorylation patterns in phosphopeptides targeting EGFR can impact their self-assembly abilities and binding affinity for EGFR. The phosphorylated peptide pY1 shows the highest capability for preorganization and the fastest dephosphorylation in the presence of alkaline phosphatase (ALP), making it the most effective at constructing stable peptide assemblies on cancer cell membranes. Additionally, peptide-protein and peptide-peptide co-assembly strategies are employed to apply antigens to cancer cell membranes, offering a potential technique for cancer immunotherapy.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2023)

添加到收藏夹

Article Materials Science, Biomaterials

Antiviral supramolecular polymeric hydrogels by self-assembly of tenofovir-bearing peptide amphiphiles

Maya K. Monroe et al.

Summary: The development of long-acting antiviral therapeutic delivery systems is crucial for improving the treatment and prevention of HIV and chronic HBV. This study reports the conjugation of tenofovir to rationally designed peptide amphiphiles to create antiviral prodrug hydrogelators. The resulting conjugates can self-assemble into one-dimensional nanostructures and undergo rapid gelation to form a drug depot. Our findings suggest that minor changes in peptide design can affect gelation and release.

BIOMATERIALS SCIENCE (2023)

添加到收藏夹

Article Chemistry, Multidisciplinary

Supramolecular Filament Hydrogel as a Universal Immunomodulator Carrier for Immunotherapy Combinations

Feihu Wang et al.

Summary: A peptide-based supramolecular filament hydrogel was designed and synthesized as a carrier for localized delivery of three immunomodulating agents. The hydrogel acted as a depot for sustained release of the immunotherapeutic agents, resulting in enhanced antitumor activities and reduced side effects. Combination therapy using the hydrogel led to complete regression of tumors and elicited a systemic antitumor immunity. This hydrogel offers a simple and generalizable strategy for local delivery of immunomodulators, improving treatment outcomes.

ACS NANO (2023)

添加到收藏夹

Article Multidisciplinary Sciences

Self-assembling paclitaxel-mediated stimulation of tumor-associated macrophages for postoperative treatment of glioblastoma

Feihu Wang et al.

Summary: We report on a self-assembling paclitaxel filament hydrogel that stimulates macrophage-mediated immune response for local treatment of recurrent glioblastoma. The paclitaxel filaments elicit an immune-stimulating tumor microenvironment and sensitizes tumor to the aCD47-mediated blockade, promoting tumor cell phagocytosis by macrophages and triggering an antitumor T cell response. As adjuvant therapy after surgery, this aCD47/PF supramolecular hydrogel effectively suppresses primary brain tumor recurrence and prolongs overall survivals.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2023)

添加到收藏夹

Article Chemistry, Multidisciplinary

Energy Landscapes of Supramolecular Peptide-Drug Conjugates Directed by Linker Selection and Drug Topology

Matthew J. Sis et al.

Summary: Peptide-drug conjugates that self-assemble into supramolecular nanomaterials have potential applications in drug delivery. These molecules can efficiently carry therapeutic agents and possess biological targeting and stimuli-responsive function. The contributions of the drug and its linker to the self-assembly process are non-negligible and affect the form and assembly of the resultant nanomaterial.

ACS NANO (2022)

添加到收藏夹

Review Pharmacology & Pharmacy

Supramolecular nanomedicines through rational design of self-assembling prodrugs

Han Wang et al.

Summary: Advancements in nanomaterial development have led to the creation of functional drug delivery vehicles. The prodrug strategy provides a simple solution for creating nanomedicines and combining different functionalities. This review also discusses the opportunities and challenges in this rapidly growing field.

TRENDS IN PHARMACOLOGICAL SCIENCES (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Leveraging the therapeutic, biological, and self-assembling potential of peptides for the treatment of viral infections

Maya K. Monroe et al.

Summary: Peptides and peptide-based materials play an important role in the treatment of viral infections as active pharmaceutical ingredients, targeting moieties, excipients, carriers, or structural components in drug delivery systems. Peptides have the ability to bind cell receptors, facilitate membrane penetration, and facilitate intracellular trafficking, making them useful in improving targeting efficiency and treatment efficacy in various antiviral systems. Additionally, the self-assembly of peptides provides a diverse library of constructs and biomaterials for systemic and local delivery of antiviral agents.

JOURNAL OF CONTROLLED RELEASE (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Machine learning overcomes human bias in the discovery of self-assembling peptides

Rohit Batra et al.

Summary: Peptide materials have a wide range of functions, but increasing the sequence length leads to a larger number of candidate sequences. Traditional design methods guided by human expertise and intuition are not easily scalable or free from bias. This article introduces a machine learning-based computational search engine that efficiently discovers peptide sequences with high self-assembly potential, overcoming human bias and accelerating peptide discovery.

NATURE CHEMISTRY (2022)

添加到收藏夹

Review Nanoscience & Nanotechnology

pH-Responsive Self-Assembling Peptide-Based Biomaterials: Designs and Applications

Zhao Li et al.

Summary: Stimuli-responsive peptide-based biomaterials, particularly pH-responsive ones, have great potential in drug delivery and tissue engineering. By incorporating pH-responsive amino acids and organic linkers into peptides, they can self-assemble into various nanostructures. These biocompatible and adjustable platforms are ideal for drug release and mimicking the extracellular matrix. This review focuses on the design motifs and mechanisms of pH-responsiveness in self-assembling peptide-based biomaterials, highlighting recent advances in drug delivery and tissue engineering, and discussing future challenges and areas for development.

ACS APPLIED BIO MATERIALS (2022)

添加到收藏夹

Article Materials Science, Biomaterials

Multidomain peptide hydrogel adjuvants elicit strong bias towards humoral immunity

Brett H. Pogostin et al.

Summary: Multidomain peptides (MDPs) are materials that can form injectable supramolecular hydrogels under physiological conditions. Loading antigen into MDP hydrogels does not affect their rheological properties, and they can act as antigen depots. MDP adjuvanted vaccines enhance humoral immunity but do not elicit a strong cellular immune response.

BIOMATERIALS SCIENCE (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Propagation-Instigated Self-Limiting Polymerization of Multiarmed Amphiphiles into Finite Supramolecular Polymers

Hao Su et al.

Summary: The study aims to achieve precise control over the size and size distribution of supramolecular polymers, using self-limiting supramolecular polymerization chemistry to effectively control the length and polydispersity of molecular chains by grafting multi-armed OEG segments onto aromatic segments.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

添加到收藏夹

Article Nanoscience & Nanotechnology

Surface-fill hydrogel attenuates the oncogenic signature of complex anatomical surface cancer in a single application

Poulami Majumder et al.

Summary: The authors engineered a peptide-based surface-fill hydrogel (SFH) that can be applied to surface cancers during surgery to effectively reduce the risk of tumor recurrence post-surgery.

NATURE NANOTECHNOLOGY (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Supramolecular Design of Unsymmetric Reverse Bolaamphiphiles for Cell-Sensitive Hydrogel Degradation and Drug Release

Rami W. Chakroun et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Self-assembling and self-formulating prodrug hydrogelator extends survival in a glioblastoma resection and recurrence model

Paula Schiapparelli et al.

JOURNAL OF CONTROLLED RELEASE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

The role of critical micellization concentration in efficacy and toxicity of supramolecular polymers

Hao Su et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Multifunctional Antimicrobial Biometallohydrogels Based on Amino Acid Coordinated Self-Assembly

Jingwen Song et al.

SMALL (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Supramolecular prodrug hydrogelator as an immune booster for checkpoint blocker-based immunotherapy

Feihu Wang et al.

SCIENCE ADVANCES (2020)

添加到收藏夹

Article Chemistry, Physical

A year-long extended release nanoformulated cabotegravir prodrug

Tanmay A. Kulkarni et al.

NATURE MATERIALS (2020)

添加到收藏夹

Review Pharmacology & Pharmacy

Long-acting approaches for delivery of antiretroviral drugs for prevention and treatment of HIV: a review of recent research

Denise A. Cobb et al.

EXPERT OPINION ON DRUG DELIVERY (2020)

添加到收藏夹

Article Engineering, Biomedical

Tumour sensitization via the extended intratumoural release of a STING agonist and camptothecin from a self-assembled hydrogel

Feihu Wang et al.

NATURE BIOMEDICAL ENGINEERING (2020)

添加到收藏夹

Review Engineering, Biomedical

Crafting Polymeric and Peptidic Hydrogels for Improved Wound Healing

David Stern et al.

ADVANCED HEALTHCARE MATERIALS (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Fine-Tuning the Linear Release Rate of Paclitaxel-Bearing Supramolecular Filament Hydrogels through Molecular Engineering

Rami W. Chakroun et al.

ACS NANO (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Paclitaxel-Promoted Supramolecular Polymerization of Peptide Conjugates

Hao Su et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Macrocyclization of a Class of Camptothecin Analogues into Tubular Supramolecular Polymers

Hao Su et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Harnessing nanostructured systems for improved treatment and prevention of HIV disease

Maya Monroe et al.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2018)

添加到收藏夹

Review Chemistry, Multidisciplinary

Molecular engineering solutions for therapeutic peptide delivery

Handan Acar et al.

CHEMICAL SOCIETY REVIEWS (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

Electrostatic-Driven Lamination and Untwisting of β-Sheet Assemblies

Yang Hu et al.

ACS NANO (2016)

添加到收藏夹

Article Chemistry, Multidisciplinary

Switching the Immunogenicity of Peptide Assemblies Using Surface Properties

Yi Wen et al.

ACS NANO (2016)

添加到收藏夹

Review Chemistry, Physical

Supramolecular biomaterials

Matthew J. Webber et al.

NATURE MATERIALS (2016)

添加到收藏夹

Article Chemistry, Physical

Energy landscapes and functions of supramolecular systems

Faifan Tantakitti et al.

NATURE MATERIALS (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Beta Hairpin Peptide Hydrogels as an Injectable Solid Vehicle for Neurotrophic Growth Factor Delivery

Stephan Lindsey et al.

BIOMACROMOLECULES (2015)

添加到收藏夹

Review Chemistry, Multidisciplinary

Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials

Xuewen Du et al.

CHEMICAL REVIEWS (2015)

添加到收藏夹

Article Cell & Tissue Engineering

Biocompatibility and Characterization of a Peptide Amphiphile Hydrogel for Applications in Peripheral Nerve Regeneration

Katie A. Black et al.

TISSUE ENGINEERING PART A (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Controlled analysis of nanoparticle charge on mucosal and systemic antibody responses following pulmonary immunization

Catherine A. Fromen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

添加到收藏夹

Article Chemistry, Multidisciplinary

Amino Acid Sequence in Constitutionally Isomeric Tetrapeptide Amphiphiles Dictates Architecture of One-Dimensional Nanostructures

Honggang Cui et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

添加到收藏夹

Article Chemistry, Multidisciplinary

Supramolecular Nanostructures Formed by Anticancer Drug Assembly

Andrew G. Cheetham et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)

添加到收藏夹

Article Engineering, Biomedical

Controlled release of dexamethasone from peptide nanofiber gels to modulate inflammatory response

Matthew J. Webber et al.

BIOMATERIALS (2012)

添加到收藏夹

Review Multidisciplinary Sciences

Functional Supramolecular Polymers

T. Aida et al.

SCIENCE (2012)

添加到收藏夹

Review Biochemistry & Molecular Biology

Self-Assembly of Peptide Amphiphiles: From Molecules to Nanostructures to Biomaterials

Honggang Cui et al.

BIOPOLYMERS (2010)

添加到收藏夹

Article Chemistry, Multidisciplinary

Self-Assembling Multidomain Peptide Hydrogels: Designed Susceptibility to Enzymatic Cleavage Allows Enhanced Cell Migration and Spreading

Kerstin M. Galler et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

添加到收藏夹

Review Chemistry, Multidisciplinary

Molecular hydrogels of therapeutic agents

Fan Zhao et al.

CHEMICAL SOCIETY REVIEWS (2009)

添加到收藏夹

Article Polymer Science

Dependence of Self-Assembled Peptide Hydrogel Network Structure on Local Fibril Nanostructure

Rohan A. Hule et al.

MACROMOLECULES (2009)

添加到收藏夹

Article Chemistry, Multidisciplinary

Self-Assembly of Giant Peptide Nanobelts

Honggeng Cui et al.

NANO LETTERS (2009)

添加到收藏夹

Article Medicine, General & Internal

Abacavir-Lamivudine versus Tenofovir-Emtricitabine for Initial HIV-1 Therapy

Paul E. Sax et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

添加到收藏夹

Article Chemistry, Multidisciplinary

Inherent antibacterial activity of a peptide-based β-hairpin hydrogel

Daphne A. Salick et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)

添加到收藏夹

Article Chemistry, Multidisciplinary

Self-assembly of multidomain peptides: Balancing molecular frustration controls conformation and nanostructure

He Dong et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)

添加到收藏夹

Article Multidisciplinary Sciences

Controlling hydrogelation kinetics by peptide design for three-dimensional encapsulation and injectable delivery of cells

Lisa Haines-Butterick et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

添加到收藏夹

Article Medicine, General & Internal

Tenofovir DF, emtricitabine, and efavirenz vs. zidovudine, lamivudine, and efavirenz for HIV

JE Gallant et al.

NEW ENGLAND JOURNAL OF MEDICINE (2006)

添加到收藏夹

Article Chemistry, Multidisciplinary

Laminated morphology of nontwisting β-sheet fibrils constructed via peptide self-assembly

MS Lamm et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)

添加到收藏夹

Article Engineering, Biomedical

Self-assembling peptide amphiphile nanofiber matrices for cell entrapment

E Beniash et al.

ACTA BIOMATERIALIA (2005)

添加到收藏夹

Article Medicine, General & Internal

Lamivudine for patients with chronic hepatitis B and advanced liver disease

YF Liaw et al.

NEW ENGLAND JOURNAL OF MEDICINE (2004)

添加到收藏夹

Article Chemistry, Multidisciplinary

Thermally reversible hydrogels via intramolecular folding and consequent self-assembly of a de Novo designed peptide

DJ Pochan et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)

添加到收藏夹

Article Chemistry, Multidisciplinary

Responsive hydrogels from the intramolecular folding and self-assembly of a designed peptide

JP Schneider et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2002)

添加到收藏夹

Article Multidisciplinary Sciences

Rapidly recovering hydrogel scaffolds from self-assembling diblock copolypeptide amphiphiles

AP Nowak et al.

NATURE (2002)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.