4.8 Article

Palladium and Iron Cocatalyzed Aerobic Alkene Aminoboration

期刊

出版社

AMER CHEMICAL SOC
DOI: 10.1021/jacs.3c05790

关键词

-

向作者/读者索取更多资源

In this study, the authors report a palladium/iron cocatalyzed aminoboration reaction that can successfully catalyze the aminoboration of simple alkenes. The iron cocatalyst plays a crucial role in releasing the transmetalation-active cationic alkylpalladium intermediate and acting as a redox shuttle in the regeneration of the Pd(II) catalyst.
Aminoboration of simple alkenes with nitrogen nucleophilesremainsan unsolved problem in synthetic chemistry; this transformation canbe catalyzed by palladium via aminopalladation followedby transmetalation with a diboron reagent. However, this catalyticprocess faces inherent challenges with instability of the alkylpalladium(II)intermediate toward & beta;-hydride elimination. Herein, we reporta palladium/iron cocatalyzed aminoboration, which enables this transformation.We demonstrate these conditions on a variety of alkenes and norborneneswith an array of common nitrogen nucleophiles. In the developed strategy,the iron cocatalyst is crucial to achieving the desired reactivityby serving as a halophilic Lewis acid to release the transmetalation-activecationic alkylpalladium intermediate. Furthermore, it serves as aredox shuttle in the regeneration of the Pd(II) catalyst by reactivationof nanoparticulate palladium.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.8
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据