期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 145, 期 38, 页码 21027-21039出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.3c06961
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This study describes the synthesis of phosphino(oxazoline)pyridine-supported molybdenum(0) cycloocta-1,5-diene complexes and their reactions with dihydrogen and arenes. The study found that the site selectivity of arene insertion reactions depended on the size of the substituent, and electron-rich arenes had faster insertion rates. Additionally, through mechanistic studies, the synthesis of enantioenriched cyclohexa-1,3-diene was achieved.
The synthesis of phosphino(oxazoline)pyridine-supported molybdenum(0) cycloocta-1,5-diene complexes is described. Exposure of these complexes to dihydrogen in the presence of an arene resulted in insertion of the substrate into the molybdenum hydride bond and afforded the corresponding molybdenum cyclohexadienyl hydrides. For mono- and disubstituted arenes, the site selectivity for insertion of the most substituted bond increases with increasing size of the substituent from methyl to ethyl, iso-propyl, and tert-butyl. In contrast, 1,3,5-trisubstituted arenes underwent insertion with exclusive site selectivity. Relative rates of insertion were determined by competition experiments and established faster insertions for electron-rich arenes. Introduction of electron-withdrawing trifluoromethyl groups on the arene resulted in decreased relative rates of insertion and an increased rate for H(2 )reductive elimination, favoring formation of the corresponding molybdenum ?(6)-arene complex. Studies on the reductive elimination of the cyclohexadienyl ligand with the hydride enabled the synthesis of an enantioenriched cyclohexa-1,3-diene. This study provides new insights into the ligand requirements for catalytic arene hydrogenation and a new strategy for selective arene reduction.
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