期刊
MOLECULAR BIOSYSTEMS
卷 12, 期 6, 页码 1768-1771出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6mb00250a
关键词
-
资金
- Damon Runyon Cancer Research Foundation
- Boston College
- NIH [1R01GM118431-01A1]
Glutathione S-transferase Pi (GSTP1) mediates cellular defense against reactive electrophiles. Here, we report LAS17, a dichlorotriazine-containing compound that irreversibly inhibits GSTP1 and is selective for GSTP1 within cellular proteomes. Mass spectrometry and mutational studies identified Y108 as the site of modification, providing a unique mode of GSTP1 inhibition.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据