期刊
JOURNAL OF SEPARATION SCIENCE
卷 -, 期 -, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.202300425
关键词
electrospray ionization; mass spectrometry; poly(ethylene glycol); polymers; supercritical fluid chromatography
Poly(ethylene glycols) are complex polymers commonly added to pharmaceutical formulations for improved drug solubility and delivery. This study employs a supercritical fluid chromatography-mass spectrometry approach to selectively ionize poly(ethylene glycols) as ammoniated molecules, simplifying data analysis and enabling batch-to-batch comparisons.
Poly(ethylene glycols) are complex polymers often added to pharmaceutical formulations to improve drug solubility and delivery. One of the main challenges when using chromatographic techniques coupled to mass spectrometry is the unselective ionization of poly(ethylene glycols) oligomers. Additionally, when the chain length is large enough, multiple charged species are formed, further complicating the mass spectra and processing. This study uses the advanced oligomer separation provided by supercritical fluid chromatography with a mass spectrometry approach that selectively ionizes poly(ethylene glycols) as ammoniated molecules to simplify data analysis and facilitate batch-to-batch comparisons. Several visual representations of the response of the ionization events based on the polymer molecular weight and the repeating unit were used to elucidate trends in ionization. Evaluation of the influence of the oligomer length and end-group on the electrospray ionization of the polymer allowed the development of a process to enable selective ionization for these complex polymers.
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