相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Dihydroartemisinin-piperaquine resistance in Plasmodium falciparum malaria in Cambodia: a multisite prospective cohort study
Chanaki Amaratunga et al.
LANCET INFECTIOUS DISEASES (2016)
Therapeutic Efficacy of Chloroquine for the Treatment of Uncomplicated Plasmodium falciparum in Haiti after Many Decades of its Use
Bernard A. Okech et al.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2015)
A Conservative lsoleucine to Leucine Mutation Causes Major Rearrangements and Cold Sensitivity in KlenTaq1 DNA Polymerase
Eugene Y. Wu et al.
BIOCHEMISTRY (2015)
Functional Comparison of 45 Naturally Occurring Isoforms of the Plasmodium falciparum Chloroquine Resistance Transporter (PfCRT)
Paul S. Callaghan et al.
BIOCHEMISTRY (2015)
Plasmodium falciparum dihydroartemisinin-piperaquine failures in Cambodia are associated with mutant K13 parasites presenting high survival rates in novel piperaquine in vitro assays: retrospective and prospective investigations
Valentine Duru et al.
BMC MEDICINE (2015)
Plasmodium falciparum field isolates from areas of repeated emergence of drug resistant malaria show no evidence of hypermutator phenotype
Tyler S. Brown et al.
INFECTION GENETICS AND EVOLUTION (2015)
Temporal changes in Plasmodium falciparum anti-malarial drug sensitivity in vitro and resistance-associated genetic mutations in isolates from Papua New Guinea
Tamarah Koleala et al.
MALARIA JOURNAL (2015)
Balancing drug resistance and growth rates via compensatory mutations in the Plasmodium falciparum chloroquine resistance transporter
Ines Petersen et al.
MOLECULAR MICROBIOLOGY (2015)
A novel multiple-stage antimalarial agent that inhibits protein synthesis
Beatriz Baragana et al.
NATURE (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum
Olivo Miotto et al.
NATURE GENETICS (2015)
Evolutionary consequences of drug resistance: shared principles across diverse targets and organisms
Diarmaid Hughes et al.
NATURE REVIEWS GENETICS (2015)
Advances in molecular genetic systems in malaria
Tania F. de Koning-Ward et al.
NATURE REVIEWS MICROBIOLOGY (2015)
Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation in pfcrt
Stephane Pelleau et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Delayed commitment to evolutionary fate in antibiotic resistance fitness landscapes
Adam C. Palmer et al.
NATURE COMMUNICATIONS (2015)
Independent Emergence of Artemisinin Resistance Mutations Among Plasmodium falciparum in Southeast Asia
Shannon Takala-Harrison et al.
JOURNAL OF INFECTIOUS DISEASES (2015)
K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates
Judith Straimer et al.
SCIENCE (2015)
Polymorphisms in Plasmodium falciparum Chloroquine Resistance Transporter and Multidrug Resistance 1 Genes: Parasite Risk Factors that Affect Treatment Outcomes for P-falciparum Malaria after Artemether-Lumefantrine and Artesunate-Amodiaquine
Meera Venkatesan et al.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2014)
Chloroquine Remains Effective for Treating Plasmodium vivax Malaria in Pursat Province, Western Cambodia
Chanaki Amaratunga et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)
What can we learn from fitness landscapes?
Daniel L. Hartl
CURRENT OPINION IN MICROBIOLOGY (2014)
DNA sequence polymorphisms of the pfmdr1 gene and association of mutations with the pfcrt gene in Indian Plasmodium falciparum isolates
Kshipra Chauhan et al.
INFECTION GENETICS AND EVOLUTION (2014)
Differential Prevalence of Transporter Polymorphisms in Symptomatic and Asymptomatic Falciparum Malaria Infections in Uganda
Stephen Tukwasibwe et al.
JOURNAL OF INFECTIOUS DISEASES (2014)
Directional Selection at the pfmdr1, pfcrt, pfubp1, and pfap2mu Loci of Plasmodium falciparum in Kenyan Children Treated With ACT
Gisela Henriques et al.
JOURNAL OF INFECTIOUS DISEASES (2014)
Origin of Robustness in Generating Drug-Resistant Malaria Parasites
Krittikorn Kuempornsin et al.
MOLECULAR BIOLOGY AND EVOLUTION (2014)
Return of chloroquine-sensitive Plasmodium falciparum parasites and emergence of chloroquine-resistant Plasmodium vivax in Ethiopia
Seleshi Kebede Mekonnen et al.
MALARIA JOURNAL (2014)
A molecular marker of artemisinin-resistant Plasmodium falciparum malaria
Frederic Ariey et al.
NATURE (2014)
Dihydroartemisinin-Piperaquine Failure in Cambodia
David L. Saunders et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite's chloroquine resistance transporter
Robert L. Summers et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Full-Length Sequence Analysis of Chloroquine Resistance Transporter Gene inPlasmodium falciparumIsolates from Sabah, Malaysia
Lii Lian Tan et al.
TheScientificWorldJOURNAL (2014)
Pfcrt mutant haplotypes may not correspond with chloroquine resistance
Diganta Goswami et al.
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES (2014)
Generation of Antigenic Diversity in Plasmodium falciparum by Structured Rearrangement of Var Genes During Mitosis
Antoine Claessens et al.
PLOS GENETICS (2014)
Metabolic QTL Analysis Links Chloroquine Resistance in Plasmodium falciparum to Impaired Hemoglobin Catabolism
Ian A. Lewis et al.
PLOS GENETICS (2014)
Insights into the Role of Heme in the Mechanism of Action of Antimalarials
Jill M. Combrinck et al.
ACS CHEMICAL BIOLOGY (2013)
Molecular Surveillance as Monitoring Tool for Drug-Resistant Plasmodium falciparum in Suriname
Malti R. Adhin et al.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2013)
Function of Resistance Conferring Plasmodium falciparum Chloroquine Resistance Transporter Isoforms
Nicholas K. Baro et al.
BIOCHEMISTRY (2013)
Dual-functioning antimalarials that inhibit the chloroquine-resistance transporter
Timothy J. Egan et al.
FUTURE MICROBIOLOGY (2013)
Accessible Mutational Trajectories for the Evolution of Pyrimethamine Resistance in the Malaria Parasite Plasmodium vivax
Pan-Pan Jiang et al.
JOURNAL OF MOLECULAR EVOLUTION (2013)
The interplay between drug resistance and fitness in malaria parasites
Philip J. Rosenthal
MOLECULAR MICROBIOLOGY (2013)
Selection for chloroquine-sensitive Plasmodium falciparum by wild Anopheles arabiensis in Southern Zambia
Sungano Mharakurwa et al.
MALARIA JOURNAL (2013)
A comprehensive survey of polymorphisms conferring anti-malarial resistance in Plasmodium falciparum across Pakistan
Aamer A. Khattak et al.
MALARIA JOURNAL (2013)
Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia
Olivo Miotto et al.
NATURE GENETICS (2013)
Mitotic Evolution of Plasmodium falciparum Shows a Stable Core Genome but Recombination in Antigen Families
Selina E. R. Bopp et al.
PLOS GENETICS (2013)
Know your enemy: understanding the role of PfCRT in drug resistance could lead to new antimalarial tactics
Robert L. Summers et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2012)
Mutant pfcrt SVMNT haplotype and wild type pfmdr1 N86 are endemic in Plasmodium vivax dominated areas of India under high chloroquine exposure
Prashant K. Mallick et al.
MALARIA JOURNAL (2012)
Site-specific genome editing in Plasmodium falciparum using engineered zinc-finger nucleases
Judith Straimer et al.
NATURE METHODS (2012)
Adaptive evolution: evaluating empirical support for theoretical predictions
Carrie F. Olson-Manning et al.
NATURE REVIEWS GENETICS (2012)
Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite
Daniel J. Park et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
PfCRT and its role in antimalarial drug resistance
Andrea Ecker et al.
TRENDS IN PARASITOLOGY (2012)
Piperaquine Resistance Is Associated with a Copy Number Variation on Chromosome 5 in Drug-Pressured Plasmodium falciparum Parasites
Richard T. Eastman et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2011)
PfCRT-Mediated Drug Transport in Malarial Parasites
Paul D. Roepe
BIOCHEMISTRY (2011)
Identifying apicoplast-targeting antimalarials using high-throughput compatible approaches
Eric H. Ekland et al.
FASEB JOURNAL (2011)
Evidence That Mutant PfCRT Facilitates the Transmission to Mosquitoes of Chloroquine-Treated Plasmodium Gametocytes
Andrea Ecker et al.
JOURNAL OF INFECTIOUS DISEASES (2011)
Fitness Trade-Offs in the Evolution of Dihydrofolate Reductase and Drug Resistance in Plasmodium falciparum
Marna S. Costanzo et al.
PLOS ONE (2011)
Amodiaquine Resistance in Plasmodium falciparum Malaria in Afghanistan Is Associated with the pfcrt SVMNT Allele at Codons 72 to 76
Khalid Beshir et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)
pfmdr1 Amplification and Fixation of pfcrt Chloroquine Resistance Alleles in Plasmodium falciparum in Venezuela
Sean Griffing et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)
Transporters as mediators of drug resistance in Plasmodium falciparum
Cecilia P. Sanchez et al.
INTERNATIONAL JOURNAL FOR PARASITOLOGY (2010)
Return of Chloroquine-Susceptible Falciparum Malaria in Malawi Was a Reexpansion of Diverse Susceptible Parasites
Miriam K. Laufer et al.
JOURNAL OF INFECTIOUS DISEASES (2010)
Compensatory Mutations Restore Fitness during the Evolution of Dihydrofolate Reductase
Kyle M. Brown et al.
MOLECULAR BIOLOGY AND EVOLUTION (2010)
Chloroquine susceptibility and reversibility in a Plasmodium falciparum genetic cross
Jigar J. Patel et al.
MOLECULAR MICROBIOLOGY (2010)
Protecting the malaria drug arsenal: halting the rise and spread of amodiaquine resistance by monitoring the PfCRT SVMNT type
Juliana M. Sa et al.
MALARIA JOURNAL (2010)
Plasmodium falciparum isolates from Angola show the StctVMNT haplotype in the pfcrt gene
Bianca E. Gama et al.
MALARIA JOURNAL (2010)
The Selection Landscape of Malaria Parasites
M. J. Mackinnon et al.
SCIENCE (2010)
Identification of a Mutant PfCRT-Mediated Chloroquine Tolerance Phenotype in Plasmodium falciparum
Stephanie G. Valderramos et al.
PLOS PATHOGENS (2010)
Revealing evolutionary pathways by fitness landscape reconstruction
Manjunatha Kogenaru et al.
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2009)
Molecular and physiologic basis of quinoline drug resistance in Plasmodium falciparum malaria
Paul D. Roepe
FUTURE MICROBIOLOGY (2009)
In Vivo Selection of Plasmodium falciparum Parasites Carrying the Chloroquine-Susceptible pfcrt K76 Allele after Treatment with Artemether-Lumefantrine in Africa
Christin Sisowath et al.
JOURNAL OF INFECTIOUS DISEASES (2009)
Analysis of genetic mutations associated with anti-malarial drug resistance in Plasmodium falciparum from the Democratic Republic of East Timor
Afonso de Almeida et al.
MALARIA JOURNAL (2009)
Chloroquine and sulphadoxine-pyrimethamine sensitivity of Plasmodium falciparum parasites in a Brazilian endemic area
Bianca Ervatti Gama et al.
MALARIA JOURNAL (2009)
Chloroquine resistance before and after its withdrawal in Kenya
Leah Mwai et al.
MALARIA JOURNAL (2009)
Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria
Richard T. Eastman et al.
NATURE REVIEWS MICROBIOLOGY (2009)
Stepwise acquisition of pyrimethamine resistance in the malaria parasite
Elena R. Lozovsky et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Geographic patterns of Plasmodium falciparum drug resistance distinguished by differential responses to amodiaquine and chloroquine
Juliana Martha Sa et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Discordant patterns of genetic variation at two chloroquine resistance loci in worldwide populations of the malaria parasite Plasmodium falciparum
Rajeev K. Mehlotra et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2008)
Qinghaosu (Artemisinin): The price of success
N. J. White
SCIENCE (2008)
No genetic bottleneck in Plasmodium falciparum wild-type pfcrt alleles reemerging in Hainan Island, China, following high-level chloroquine resistance
Nanhua Chen et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2008)
Seasonal carriage of pfcrt and pfmdr1 alleles in Gambian Plasmodium falciparum imply reduced fitness of chloroquine-resistant parasites
Rosalynn Ord et al.
JOURNAL OF INFECTIOUS DISEASES (2007)
Empirical fitness landscapes reveal accessible evolutionary paths
Frank J. Poelwijk et al.
NATURE (2007)
Darwinian evolution can follow only very few mutational paths to fitter proteins
DM Weinreich et al.
SCIENCE (2006)
A critical role for PfCRT K76T in Plasmodium falciparum verapamil-reversible chloroquine resistance
V Lakshmanan et al.
EMBO JOURNAL (2005)
pfcrt is more than the Plasmodium falciparum chloroquine resistance gene:: a functional and evolutionary perspective
RA Cooper et al.
ACTA TROPICA (2005)
Missense meanderings in sequence space: A biophysical view of protein evolution
MA DePristo et al.
NATURE REVIEWS GENETICS (2005)
Ferriprotoporphyrin IX, phospholipids, and the antimalarial actions of quinoline drugs
CD Fitch
LIFE SCIENCES (2004)
Evidence for a central role for PfCRT in conferring Plasmodium falciparum resistance to diverse antimalarial agents
DJ Johnson et al.
MOLECULAR CELL (2004)
pfcrt polymorphism and the spread of chloroquine resistance in Plasmodium falciparum populations across the Amazon Basin
PP Vieira et al.
JOURNAL OF INFECTIOUS DISEASES (2004)
Chloroquine resistance modulated in vitro by expression levels of the Plasmodium falciparum chloroquine resistance transporter
KL Waller et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations
ABS Sidhu et al.
SCIENCE (2002)
Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum
JC Wootton et al.
NATURE (2002)
Epidemiology of drug-resistant malaria
C Wongsrichanalai et al.
LANCET INFECTIOUS DISEASES (2002)
Evolution of a unique Plasmodium falciparum chloroquine-resistance phenotype in association with pfcrt polymorphism in Papua New Guinea and South America
RK Mehlotra et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
A molecular marker for chloroquine-resistant falciparum malaria
A Djimdé et al.
NEW ENGLAND JOURNAL OF MEDICINE (2001)
The public health impact of chloroquine resistance in Africa
JF Trape
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2001)
Mutations in the P-falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance
DA Fidock et al.
MOLECULAR CELL (2000)