期刊
JOURNAL OF PSYCHIATRIC RESEARCH
卷 165, 期 -, 页码 91-95出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jpsychires.2023.07.022
关键词
ketamine; Vascular endothelial growth factor; Matrix metalloproteinase-9; Treatment-resistant depression; Suicide
类别
This study found that low-dose ketamine did not alter the levels of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) in patients with treatment-resistant depression and strong suicidal ideation. However, baseline VEGF levels were associated with the antidepressant and antisuicidal effects of a single low-dose ketamine infusion.
Background: Evidence indicates that vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) influence the pathophysiology of depression. However, whether low-dose ketamine regulates VEGF and MMP-9 levels and whether changes in VEGF and MMP-9 levels are associated with the antidepressant and antisuicidal effects of ketamine remained unclear.Methods: Forty-eight patients with treatment-resistant depression and strong suicidal ideation (TRD-SI) were randomly assigned to a single infusion of 0.5-mg/kg ketamine or 0.045-mg/kg midazolam. The Montgomery-& ANGS;sberg Depression Rating Scale (MADRS) and Columbia-Suicide Severity Rating Scale-Ideation Severity Subscale (CSSRS-ISS) were used at baseline and subsequently at several postinfusion timepoints. VEGF and MMP9 serum levels were analyzed at baseline and on day 3 postinfusion.Results: After adjustment for baseline levels, no significant differences in VEGF (p = .912) and MMP-9 (p = .758) levels were identified on day 3 postinfusion between the study groups. Baseline VEGF levels but not MMP-9 levels were negatively associated with MADRS and CSSRS-ISS scores following infusion.Discussion: A single infusion of low-dose ketamine did not alter the VEGF and MMP-9 levels of the patients with TRD-SI. Higher baseline VEGF levels were associated with greater antidepressant and antisuicidal effects of single low-dose ketamine infusion.
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