Development of lymph node metastasis-related prognostic markers in breast cancer

Article Oncology

Overexpression of POU3F2 promotes radioresistance in triple-negative breast cancer via Akt pathway activation

Han Zhang et al.

Summary: High expression of POU3F2 promotes radioresistance in triple-negative breast cancer via Akt pathway activation by interacting with ARNT2.

BREAST CANCER RESEARCH AND TREATMENT (2023)

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Review Oncology

Mechanisms of breast cancer metastasis

S. David Nathanson et al.

Summary: Invasive breast cancer tends to spread to lymph nodes and other parts of the body. Management of metastasis has evolved to focus on controlling the growth of the disease through surgery, radiation, and systemic treatments, with the goal of inhibiting the proliferation of cancer cells. Understanding the mechanisms of metastasis could lead to the development of more targeted therapies and improved outcomes in breast cancer treatments.

CLINICAL & EXPERIMENTAL METASTASIS (2022)

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Article Cell Biology

TRIP13, identified as a hub gene of tumor progression, is the target of microRNA-4693-5p and a potential therapeutic target for colorectal cancer

Yan Chen et al.

Summary: This study identified TRIP13 as a potential target for colorectal cancer (CRC) therapy. It was found that TRIP13 played a crucial role in CRC progression, and could be downregulated by miR-4693-5p. Small molecule inhibitor DCZ0415 targeting TRIP13 exhibited anti-tumor activity in vitro and in vivo.

CELL DEATH DISCOVERY (2022)

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Article Oncology

Identification of a pyroptosis-related prognostic signature in breast cancer

Hanghang Chen et al.

Summary: A 16-gene signature was developed to predict the prognosis of breast cancer patients based on the analysis of pyroptosis-related gene expression data. The signature showed excellent prognostic performance in two independent patient cohorts. It was closely associated with the tumor immune microenvironment and correlated with tumor mutational burden as well.

BMC CANCER (2022)

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Article Medical Laboratory Technology

Novel biomarkers identified in triple-negative breast cancer through RNA-sequencing

Yan-li Chen et al.

Summary: By using RNA-sequencing and bioinformatics analysis, specific biomarkers for TNBC were identified, with FERMT1 found to be significantly upregulated in TNBC tumor tissues and its increased expression associated with poor overall survival of TNBC patients. FERMT1 could potentially serve as a specific biomarker and therapeutic target in TNBC.

CLINICA CHIMICA ACTA (2022)

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Article Oncology

Circ_ZFR affects FABP7 expression to regulate breast cancer progression by acting as a sponge for miR-223-3p

Xiuling Tian et al.

Summary: This study found that circ_ZFR may act as a sponge for miR-223-3p to regulate FABP7 expression, thereby promoting proliferation, migration, invasion, and EMT of BC cells, and inhibiting cell apoptosis.

THORACIC CANCER (2022)

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Article Cell Biology

Tumor-educated Tregs drive organ-specific metastasis in breast cancer by impairing NK cells in the lymph node niche

Kevin Kos et al.

Summary: Breast cancer causes systemic immunosuppression, which affects the organotropism of metastasis. Tumor-educated regulatory T cells (T-regs) accumulate in distant organs and undergo transcriptional rewiring in response to mammary tumorigenesis. T-regs control natural killer (NK) cell activation in lymph nodes, thereby promoting lymph node metastasis. The ratio of T-regs to NK cells is increased in sentinel lymph nodes of breast cancer patients compared to healthy controls.

CELL REPORTS (2022)

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Review Oncology

Dual Effect of Immune Cells within Tumour Microenvironment: Pro- and Anti-Tumour Effects and Their Triggers

Alicia Cristina Pena-Romero et al.

Summary: The relationship between the immune system and tumours is a crucial topic in cancer research. Immune cells in the tumour microenvironment can either support anti-tumour immunity or promote tumour progression. Understanding the influence of the tumour microenvironment on immune cells is essential for developing effective cancer treatments.

CANCERS (2022)

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Review Biochemistry & Molecular Biology

Breast Cancer Metastasis: Mechanisms and Therapeutic Implications

Misung Park et al.

Summary: Breast cancer is the most common malignancy in women worldwide, and metastasis is the leading cause of high mortality. Currently, breast cancer is often discovered or diagnosed after metastasis has occurred, resulting in poor prognosis. Understanding the mechanisms and nature of breast cancer metastasis can facilitate the development of targeted therapies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biochemical Research Methods

Clinical significance and immunogenomic landscape analyses of the immune cell signature based prognostic model for patients with breast cancer

Shiyuan Wang et al.

Summary: Tumor-infiltrating lymphocytes in the immune microenvironment of breast cancer patients can serve as important prognostic biomarkers. A risk score prognostic model was developed for risk stratification and prognosis prediction for breast cancer patients.

BRIEFINGS IN BIOINFORMATICS (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Biochemistry & Molecular Biology

Integrative analyses of scRNA-seq and scATAC-seq reveal CXCL14 as a key regulator of lymph node metastasis in breast cancer

Kun Xu et al.

Summary: This study revealed the cellular and molecular mechanisms of breast cancer lymph node metastasis using single-cell RNA sequencing and chromatin accessibility sequencing, identifying a novel cell subpopulation with aberrantly high expression of CXCL14 in lymph node metastases. Validation through tissue microarray and database analysis confirmed the significance of CXCL14 in lymph node metastasis of breast cancer. Additionally, potential regulatory transcription factors were identified through scATAC-seq for breast cancer lymph node metastasis.

HUMAN MOLECULAR GENETICS (2021)

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Article Oncology

A Novel Seven Gene Signature-Based Prognostic Model to Predict Distant Metastasis of Lymph Node-Negative Triple-Negative Breast Cancer

Wenting Peng et al.

Summary: This study established clinical prognostic model, seven-gene signature, and combined model for predicting distant metastasis risk in lymph node-negative TNBC patients. The seven-gene signature showed significant differentiation of distant metastasis risk in both training and validation sets. The composite clinical and gene signature demonstrated improved prognostic accuracy compared to the clinical signature.

FRONTIERS IN ONCOLOGY (2021)

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Article Health Care Sciences & Services

A practical nomogram from the SEER database to predict the prognosis of hepatocellular carcinoma in patients with lymph node metastasis

Kai Zhang et al.

Summary: This study developed a nomogram model to predict the prognosis of hepatocellular carcinoma (HCC) patients with lymph node (LN) metastasis, using data from the SEER database. The model showed good predictive performance and potential clinical utility for treating patients with LN metastasis.

ANNALS OF PALLIATIVE MEDICINE (2021)

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Article Biochemistry & Molecular Biology

Extracellular Hsp90α Promotes Tumor Lymphangiogenesis and Lymph Node Metastasis in Breast Cancer

Qiaoyun Hou et al.

Summary: The study confirms plasma Hsp90 alpha as a biomarker for breast cancer, providing insights into its prognostic value across different clinical stages, and suggests that eHsp90 alpha plays a role in promoting lymphangiogenesis in breast cancer.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Surgery

Analysis of risk factors and prognosis of 253 lymph node metastasis in colorectal cancer patients

Shidong Hu et al.

Summary: Risk factors for 253 lymph node metastasis include high CEA levels, large tumor size, more harvested lymph nodes, presence of vessel carcinoma emboli, and low levels of MSH6 and MLH1 immunohistochemical staining intensity. Elevated MLH1 immunohistochemical staining intensity is an independent protective factor. Patients with 253 lymph node-positive colorectal cancer have worse prognosis, while 253 lymph node dissection may improve the prognosis for those at high risk for 253 lymph node metastasis.

BMC SURGERY (2021)

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Article Biochemistry & Molecular Biology

Identification and Validation of Immune-Related Gene Signature for Predicting Lymph Node Metastasis and Prognosis in Lung Adenocarcinoma

Ran Jia et al.

Summary: This study identified immune-related genes associated with lymph node metastasis in lung adenocarcinoma and established a reliable risk score model for predicting lymph node metastasis in patients. The risk score was also correlated with immune cell infiltration and checkpoint gene expression, suggesting potential biomarkers for lung adenocarcinoma patients.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

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Review Oncology