4.6 Article

Evaluation of the Effects of Halloysite Nanotubes on Physical, Mechanical, and Biological Properties of Polyhydroxy Butyrate Electrospun Scaffold for Cartilage Tissue Engineering Applications

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Fabrication and assessment of bifunctional electrospun poly(L-lactic acid) scaffolds with bioglass and zinc oxide nanoparticles for bone tissue engineering

Daniel A. Canales et al.

Summary: This study developed electrospun scaffolds based on poly(L-lactic acid) (PLLA) with the addition of bioglass (n-BG) and zinc oxide (n-ZnO) nanoparticles, as well as a mixture of both, to create bifunctional biomaterials with enhanced bioactive and biocidal properties. The presence of n-BG increased fiber diameter, while ZnO did not significantly affect morphology. Mechanical properties decreased with nanoparticles. PLA/n-BG scaffolds promoted hydroxyapatite formation, which was inhibited by ZnO. Combining both nanoparticles reduced bacterial viability. The use of n-BG and n-ZnO fillers validated the development of bifunctional PLA-based scaffolds with bioactive and biocidal properties for bone tissue engineering.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2023)

Article Engineering, Biomedical

Gelatin/monetite electrospun scaffolds to regenerate bone tissue: Fabrication, characterization, and in-vitro evaluation

Yogendra Pratap Singh et al.

Summary: This study is dedicated to the preparation and characterization of electrospun gelatin/monetite nanofibrous scaffold for bone tissue engineering. The addition of monetite nanoparticles in the gelatin matrix improved the physicochemical, mechanical, and biological properties of the scaffold. The incorporation of 7 wt% monetite resulted in decreased swelling ratio, higher tensile strength and modulus, and better cell adhesion, proliferation, biomineralization, and ALP activity.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2023)

Article Polymer Science

Fibrous electrospun polycaprolactone nanomat reinforced with halloysite nanotubes: Preparation and study of its potential application as tissue engineering scaffold

Haleh Bakhtkhosh Hagh et al.

Summary: In this study, biocompatible and biodegradable polycaprolactone (PCL) was synthesized and electrospun nanocomposite scaffolds were prepared using halloysite nanotubes (HNTs) as the reinforcing agent. The PCL-HNTs nanomats showed improved morphology, fibers diameter, and wettability. The PCL + 5%HNTs composite exhibited enhanced mechanical properties and thermal stability compared to PCL. Furthermore, a GM loaded composite scaffold (PCL + 5%HNTs+GM) demonstrated prolonged drug release and excellent antibacterial effects. The PCL + 5%HNTs scaffold provided a favorable environment for cell growth, as indicated by biocompatibility and protein adsorption tests. Although the HNTs-containing sample showed higher hemolysis value, it remained below 5%.

POLYMERS FOR ADVANCED TECHNOLOGIES (2023)

Review Pharmacology & Pharmacy

Electrospinning of Potential Medical Devices (Wound Dressings, Tissue Engineering Scaffolds, Face Masks) and Their Regulatory Approach

Luca Eva Uhljar et al.

Summary: Electrospinning is a widely used technology for producing ultra-thin fibers. The morphology and physicochemical properties of the fibers depend on various factors. In the biomedical field, electrospun nanofibers have diverse applications, including medication delivery systems and tissue engineering scaffolds. The regulation of nanotechnology-made medical devices is still not properly defined. This review provides an overview of electrospinning and discusses developments in the field of electrospun medical devices, along with the relevant regulatory framework.

PHARMACEUTICS (2023)

Article Biochemistry & Molecular Biology

Evaluation of the effects of halloysite nanotube on polyhydroxybutyrate-chitosan electrospun scaffolds for cartilage tissue engineering applications

Sepideh Ghadirian et al.

Summary: This study aimed to improve the properties of poly-hydroxybutyrate (PHB) -Chitosan (Cs) electrospun scaffolds by adding halloysite nanotubes (HNT). The scaffold with 3 wt% HNT showed the most suitable features based on morphological, mechanical, and hydrophilicity evaluations. The addition of 3 wt% HNT decreased fiber diameter and increased tensile strength, surface roughness, and cell viability, making it a potential candidate for cartilage tissue engineering.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2023)

Review Cell & Tissue Engineering

Application of mesenchymal stem cell sheet for regeneration of craniomaxillofacial bone defects

Behnaz Banimohamad-Shotorbani et al.

Summary: Bone defects are common damages in human medicine, and recent advancements in cell sheet technology have offered a promising approach for osteogenesis in craniomaxillofacial (CMF) bone regeneration. The intact matrix secreted from cells provides a unique microenvironment for accelerating osteoangiogenesis. Both single-layer and multilayer cell sheets have been investigated in preclinical settings for CMF engineering, showing potential for effective bone recovery.

STEM CELL RESEARCH & THERAPY (2023)

Article Materials Science, Biomaterials

Aligned Polyhydroxyalkanoate Blend Electrospun Fibers as Intraluminal Guidance Scaffolds for Peripheral Nerve Repair

Caroline S. Taylor et al.

Summary: The use of nerve guidance conduits (NGCs) is an effective method for treating peripheral nerve injuries. However, NGCs lack the specific guidance cues found in nerve grafts and are not suitable for treating large gap injuries. The use of intraluminal aligned fiber guidance scaffolds has been shown to enhance neuronal cell neurite outgrowth and Schwann cell migration distances.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2023)

Review Materials Science, Multidisciplinary

Halloysite for clay-polymer nanocomposites: effects of nanofillers on the anti-corrosion, mechanical, microstructure, and flame-retardant properties-a review

J. Raja Beryl et al.

Summary: Polymer-clay nanocomposites are a highly remarkable nanomaterial with a wide range of applications due to their ability to impart superior properties even at low nanofiller percentages. Clay, including various types such as montmorillonite and vermiculite, is commonly used as reinforcement in the nanocomposites due to its accessibility, processability, low cost, and non-toxicity. These nanocomposites exhibit excellent thermal stability, enhanced flame retardancy, high dimensional stability, reduced gas permeability, improved anti-corrosion properties, and enhanced mechanical properties. This review particularly focuses on polymer-based nanocomposites reinforced with halloysite nanotubes, discussing their functionalization techniques, filler dispersion, and the impact of functionalized nanofillers on properties such as microstructure, mechanical strength, thermal stability, drug encapsulation, and flame retardancy. Furthermore, the challenges, key issues, future prospects, and possible mechanisms for polymeric clay nanocomposites are also reviewed.

JOURNAL OF MATERIALS SCIENCE (2023)

Review Materials Science, Ceramics

Incorporation of inorganic bioceramics into electrospun scaffolds for tissue engineering applications: A review

Elahe Bahremandi-Toloue et al.

Summary: Today, the integration of medical and engineering principles in producing biological replacements has become a hot topic. Tissue engineering utilizes the electrospinning method to create scaffolds, with the addition of ceramics to enhance their mechanical properties and biological behavior, as well as induce other effects such as improved hydrophilicity, antibacterial and antioxidant properties.

CERAMICS INTERNATIONAL (2022)

Article Engineering, Multidisciplinary

Nanoparticles distribution and agglomeration analysis in electrospun fiber based composites for desired mechanical performance of poly (3-hydroxybuty-rate-co-3-hydroxyvalerate (PHBV) scaffolds with hydroxyapatite (HA) and titanium dioxide (TiO2) towards medical applications

Joanna E. Karbowniczek et al.

Summary: In this study, the effect of ceramic nanoparticles on the mechanical properties of electrospun scaffolds was investigated. The results demonstrated that the proper distribution of ceramic particles can significantly improve the mechanical performance of the scaffolds, while irregular distribution of particles leads to deterioration.

COMPOSITES PART B-ENGINEERING (2022)

Article Biochemistry & Molecular Biology

Polycaprolactone-chitosan/multi-walled carbon nanotube: A highly strengthened electrospun nanocomposite scaffold for cartilage tissue engineering

Mohammad Hossein Mirmusavi et al.

Summary: This study fabricated electrospun nanocomposite scaffolds based on polycaprolactone (PCL)-chitosan/carboxyl-functionalized multi-walled carbon nanotubes (MWCNTs) with different concentrations of MWCNTs. The scaffolds were characterized and it was found that the scaffold containing 0.5 wt% MWCNTs had the smallest fiber diameter and highest tensile strength, with a porosity suitable for tissue engineering. Increasing the MWCNTs content decreased the water contact angle and increased the scaffold's crystallinity, leading to enhanced bioactivity and stability for cartilage healing. Chondrocytes cultured on the scaffold with MWCNTs showed good viability.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

Review Chemistry, Applied

Recent advances in modification strategies of pre- and post-electrospinning of nanofiber scaffolds in tissue engineering

Zahra Mohammadalizadeh et al.

Summary: Electrospinning is a promising method to replicate biomimetic fibrous structures. However, many nanofibers have poor interactions with cells and tissues. Thus, various strategies have been used to modify the surface of fibers in order to create a favorable microenvironment for cell attachment and proliferation, and to integrate with neighboring tissues.

REACTIVE & FUNCTIONAL POLYMERS (2022)

Article Materials Science, Multidisciplinary

Combination of polydopamine and carbon nanomaterials coating enhances the piezoelectric responses and cytocompatibility of biodegradable PLLA nanofiber scaffolds for tissue engineering applications

Madeshwaran Sekkarapatti Ramasamy et al.

Summary: This study reports a method to fabricate nanofiber scaffolds with improved piezoelectric responses, surface properties, and cytocompatibility. The modified scaffolds showed enhanced mechanical properties and hydrophilicity compared to the original scaffolds, and had higher cell attachment and proliferation abilities. These scaffolds have potential applications in tissue growth and regeneration, medical detection, and biological force sensing.

MATERIALS TODAY COMMUNICATIONS (2022)

Article Materials Science, Multidisciplinary

Improvement of mechanical properties of collagen electrospun mats by halloysite nanotubes

A. Hernandez Rangel et al.

Summary: Collagen electrospun fibers are a promising scaffold for tissue engineering, but they lack sufficient mechanical properties. In this study, halloysite nanotubes (HNT) were added to collagen solution to improve the mechanical performance of the nanofibrous mats. The results showed that the addition of HNT increased the elongation at break by 800% in a non-linear manner, and the optimal concentration of HNT was 0.5%.

JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T (2022)

Article Engineering, Biomedical

Pullulan as promoting endothelialization capacity of electrospun PCL-PU scaffold

Sonia Fathi-Karkan et al.

Summary: The objective of this project was to create engineered vascular scaffolds using polyurethane, polycaprolactone, and pullulan polymers, and the study found that PCL-PU scaffolds containing pullulan had better mechanical properties and biocompatibility, which stimulated endothelial cell proliferation.

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS (2022)

Article Biochemistry & Molecular Biology

Optimization and characterization of polyhydroxybutyrate/lignin electro-spun scaffolds for tissue engineering applications

Mohammad Mohammadalipour et al.

Summary: This study investigates the optimization of electrospinning process conditions and the addition of lignin to improve the performance of polyhydroxybutyrate (PHB) scaffolds. The results show that the addition of lignin can reduce the brittleness and hydrophobicity of PHB, improve the uniformity of electrospun nanofibers, and enhance the mechanical properties of PHB. Moreover, the PHB/lignin electrospun scaffold exhibits potential for promoting cell growth and mineralization, as well as antioxidant activity.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

Article Biochemistry & Molecular Biology

Fabrication and characterization of novel polyhydroxybutyrate-keratin/nanohydroxyapatite electrospun fibers for bone tissue engineering applications

Pooriya Sarrami et al.

Summary: The electrospun scaffolds of poly (3-hydroxybutyrate)-keratin/nanohydroxyapatite with different morphologies and weight percentages of nHA were fabricated and characterized. The addition of nHA improved the integrity, porosity, and bioactivity of the scaffolds, and enhanced their mechanical properties. Cell experiments showed positive effects of nHA on MG-63 cells, indicating the potential application of these nanocomposite scaffolds in bone tissue engineering.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

Article Materials Science, Characterization & Testing

Evaluation of intercalation and interaction in in-situ polymerized PLA-HNT bionanocomposites

P. Manju et al.

Summary: The study reported the in-situ synthesis of PLA-HNT bionanocomposites to enhance the interaction between poly(lactic acid) and halloysite nanotubes. Various analyses confirmed the successful intercalation of PLA into HNT, forming a specific crystalline structure.

POLYMERS & POLYMER COMPOSITES (2021)

Review Materials Science, Multidisciplinary

Electrospinning for tissue engineering applications

Maryam Rahmati et al.

Summary: Tissue engineering utilizes principles from medicine, biology, and engineering to design biological substitutes for tissue regeneration and maintenance. Electrospinning is a valuable technique for creating biomimetic scaffolds, with a wide range of applications in biomedical fields. Various research efforts have focused on improving cell interactions with the nano fibrous surface and addressing challenges in using electrospinning for tissue engineering and regenerative medicine.

PROGRESS IN MATERIALS SCIENCE (2021)

Review Biochemistry & Molecular Biology

Modified poly(3-hydroxybutyrate)-based scaffolds in tissue engineering applications: A review

Sanaz Soleymani Eil Bakhtiari et al.

Summary: As a member of the PHAs family, PHB has desirable properties for various medical applications, including high biocompatibility, non-toxic degradation products, and high mechanical strength. Different approaches such as PHB alloy scaffolds and composite scaffolds are used to improve its properties in tissue engineering applications.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

Article Polymer Science

Simvastatin-loaded graphene oxide embedded in polycaprolactone-polyurethane nanofibers for bone tissue engineering applications

Hessam Rezaei et al.

Summary: The study found that adding graphene oxide and simvastatin to nanofiber scaffolds can improve their structure, hydrophilicity, and absorption capacity, as well as enhance mechanical properties and physical stability, although care must be taken to avoid toxic effects. The scaffolds are biocompatible with cells, promote alkaline phosphatase activity, and demonstrate potential for bone tissue engineering applications.

JOURNAL OF POLYMER ENGINEERING (2021)

Review Engineering, Biomedical

Articular cartilage and osteochondral tissue engineering techniques: Recent advances and challenges

Wenying Wei et al.

Summary: Osteochondral defect regeneration remains a challenging issue in the musculoskeletal system, with traditional clinical treatments showing limited efficacy. However, the development of tissue engineering has provided more promising results in regenerating damaged osteochondral tissues.

BIOACTIVE MATERIALS (2021)

Article Biochemistry & Molecular Biology

Evaluation of the effects of starch on polyhydroxybutyrate electrospun scaffolds for bone tissue engineering applications

Maryam Abdollahi Asl et al.

Summary: Efficient design for bone tissue engineering involves selecting biomimetic materials and scalable fabrication technologies. In this study, PHB and starch were used to create novel scaffolds with improved tensile strength and biocompatibility. The addition of starch enhanced scaffold performance and promoted cell proliferation and activity.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

Article Chemistry, Multidisciplinary

Halloysite nanotubes and halloysite-based composites for biomedical applications

Khalida Fakhruddin et al.

Summary: Halloysite nanotubes (HNTs), as a natural material, have unique properties that make them ideal for biomedical applications, such as loading bioactive molecules and therapeutic agents. The review paper covers the characterizations, properties, and applications of HNTs-polymer nanocomposites in biomedical fields, providing an overview of their potential in personalized medicine and drug delivery methods for researchers developing novel biomaterials in biomedical engineering and health care.

ARABIAN JOURNAL OF CHEMISTRY (2021)

Proceedings Paper Materials Science, Multidisciplinary

A review on pore and porosity in tissue engineering

Puja Yadav et al.

Summary: This article discusses the impact of porosity and pore size of scaffolds on tissue engineering, emphasizing the effect on mechanical properties.

MATERIALS TODAY-PROCEEDINGS (2021)

Article Materials Science, Composites

Fabrication of polylactic acid/halloysite nanotube scaffolds by foam injection molding for tissue engineering

Meltem Eryildiz et al.

POLYMER COMPOSITES (2020)

Review Biochemistry & Molecular Biology

Cartilage biomechanics: A key factor for osteoarthritis regenerative medicine

D. Martinez-Moreno et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2019)

Review Chemistry, Multidisciplinary

Electrospinning and Electrospun Nanofibers: Methods, Materials, and Applications

Jiajia Xue et al.

CHEMICAL REVIEWS (2019)

Review Nanoscience & Nanotechnology

Advancements and frontiers in nano-based 3D and 4D scaffolds for bone and cartilage tissue engineering

Muhammad Qasim et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

Article Materials Science, Biomaterials

Potential of an electrospun composite scaffold of poly (3-hydroxybutyrate)-chitosan/alumina nanowires in bone tissue engineering applications

Elahe Bahremandi Toloue et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

Review Engineering, Biomedical

Biomaterials for articular cartilage tissue engineering: Learning from biology

A. R. Armiento et al.

ACTA BIOMATERIALIA (2018)

Review Cell & Tissue Engineering

A Guide for Using Mechanical Stimulation to Enhance Tissue-Engineered Articular Cartilage Properties

Evelia Y. Salinas et al.

TISSUE ENGINEERING PART B-REVIEWS (2018)

Article Materials Science, Multidisciplinary

Toughening of electrospun poly(L-lactic acid) nanofiber scaffolds with unidirectionally aligned halloysite nanotubes

Ning Cai et al.

JOURNAL OF MATERIALS SCIENCE (2015)

Article Orthopedics

Development of cartilage tissue engineering techniques based on biomedical research

Norimasa Iwasaki

JOURNAL OF ORTHOPAEDIC SCIENCE (2014)

Review Polymer Science

Recent advance in research on halloysite nanotubes-polymer nanocomposite

Mingxian Liu et al.

PROGRESS IN POLYMER SCIENCE (2014)

Article Cell Biology

The quality of healing: Articular cartilage

Andreas H. Gomoll et al.

WOUND REPAIR AND REGENERATION (2014)

Article Chemistry, Physical

Nanocomposites of halloysite and polylactide

Mingxian Liu et al.

APPLIED CLAY SCIENCE (2013)

Article Critical Care Medicine

Treatment of cartilage lesions: What works and why?

Maurilio Marcacci et al.

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED (2013)

Article Materials Science, Biomaterials

Chitosan-halloysite nanotubes nanocomposite scaffolds for tissue engineering

Mingxian Liu et al.

JOURNAL OF MATERIALS CHEMISTRY B (2013)

Article Engineering, Biomedical

In vitro evaluation of electrospun PCL/nanoclay composite scaffold for bone tissue engineering

Ganesh Nitya et al.

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE (2012)

Article Engineering, Manufacturing

PHBV nanocomposites based on organomodified montmorillonite and halloysite: The effect of clay type on the morphology and thermal and mechanical properties

Larissa N. Carli et al.

COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING (2011)

Article Chemistry, Physical

Tailoring the wettability of polypropylene surfaces with halloysite nanotubes

Mingxian Liu et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2010)

Article Materials Science, Multidisciplinary

Effect of electrospinning parameters on the characterization of PLA/HNT nanocomposite fibers

Ahmed H. Touny et al.

JOURNAL OF MATERIALS RESEARCH (2010)

Article Materials Science, Composites

Novel polyamide nanocomposites based on silicate nanotubes of the mineral halloysite

Katrin Hedicke-Hoechstoetter et al.

COMPOSITES SCIENCE AND TECHNOLOGY (2009)

Review Cell & Tissue Engineering

Degradation Behaviors of Electrospun Resorbable Polyester Nanofibers

Yixiang Dong et al.

TISSUE ENGINEERING PART B-REVIEWS (2009)

Review Pharmacology & Pharmacy

Engineering cartilage tissue

Cindy Chung et al.

ADVANCED DRUG DELIVERY REVIEWS (2008)

Article Biochemistry & Molecular Biology

Molecular biology of the cell, 5th edition by B. Alberts, A. Johnson, J. Lewis, M. Raff, K. Roberts, and P. Walter

John Boyle

BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION (2008)

Article Materials Science, Multidisciplinary

Porous methacrylate tissue engineering scaffolds: using carbon dioxide to control porosity and interconnectivity

John J. A. Barry et al.

JOURNAL OF MATERIALS SCIENCE (2006)