期刊
JOURNAL OF PHYSIOLOGY-LONDON
卷 -, 期 -, 页码 -出版社
WILEY
DOI: 10.1113/JP284075
关键词
circadian; food intake; gastrointestinal; obesity; plasticity; pregnancy; stomach; vagal afferent
Gastrointestinal vagal afferents play a crucial role in regulating food intake by responding to short-term and long-term changes in nutritional demand. However, this plasticity is disrupted in disease states such as obesity and chronic stress.
Gastrointestinal vagal afferents play an important role in communicating food related information from the gut to the brain. This information initiates vago-vagal reflexes essential for gut functions, including gut motility and secretions. These afferents also play a role in energy homeostasis, signalling the arrival, amount and nutrient composition of a meal to the central nervous system where it is processed ultimately leading to termination of a meal. Vagal afferent responses to food related stimuli demonstrate a high degree of plasticity, responding to short term changes in nutritional demand, such as the fluctuations that occur across a 24-hr or in response to a fast, as well as long term changes in energy demand, such as occurs during pregnancy. This plasticity is disrupted in disease states, such as obesity or chronic stress where there is hypo- and hypersensitivity of these afferents, respectively. Improved understanding of the plasticity of these afferents will enable identification of new treatment options for diseases associated with vagal afferent function.image Abstract figure legend Plasticity of gastrointestinal vagal afferents in food intake regulation.image
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