期刊
MOLECULAR ASPECTS OF MEDICINE
卷 47-48, 期 -, 页码 90-108出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mam.2015.12.002
关键词
Hypoxia; Acute oxygen sensing; Arterial chemoreceptors; Carotid body; Adrenal medulla; Oxygen-regulated ion channels; Carotid body stem cells; Acclimatization to hypoxia; Pathogenesis of disease
资金
- Botin Foundation
- Spanish Ministry of Science and Innovation [SAF2012-39343]
- European Research Council (ERC) [PRJ201502629]
Acute O-2 sensing is necessary for the activation of cardiorespiratory reflexes (hyperventilation and sympathetic activation), which permit the survival of individuals under hypoxic environments (e.g. high altitude) or medical conditions presenting with reduced capacity for gas exchange between the lung alveoli and the blood. Changes in blood O-2 tension are detected by the arterial chemoreceptors, in particular the carotid body (CB), which act in concert with the adrenal medulla (AM) to facilitate rapid adaptations to hypoxia. The field of arterial chemoreception has undergone a considerable expansion in recent years, with many of the fundamental observations made at the molecular and cellular levels serving to improve our understanding of the pathogenesis of numerous medical disorders, and even to propose advances in the treatment strategies. In this review, after a short historical preface, we describe the current model of chemosensory transduction based on the modulation of membrane K+ channels by O-2 in specialized chemoreceptor cells. Recent progress in elucidating the molecular mechanisms underlying the modulation of ion channels by O-2 tension, which involves mitochondrial complex I, is also discussed. The discovery in the last few years of a specific population of neural crest-derived stem cells in the CB explains the reversible growth of this organ, an intriguing and unusual property of this type of neuronal tissue that contributes to acclimatization under chronic hypoxia. The essential homeostatic role of the CB-AM axis is clearly evident in newly generated mouse models that reach adulthood, albeit with CB and AM atrophy. These animals exhibit a marked intolerance to even mild hypoxia. CB inhibition or over-activation can have important medical consequences. Respiratory depression by general anesthetics or by opioid use is a common clinical condition that frequently causes death in susceptible individuals. An exaggerated sympathetic outflow due to over-activation of the CB-AM axis may contribute to the pathogenesis of several highly prevalent medical conditions, such as chronic heart failure, obstructive sleep apnea, obesity, metabolic syndrome, and diabetes. A detailed understanding of the molecular mechanisms underlying acute O-2 sensing may help in the design of more efficient therapeutic approaches to combat these disorders. (C) 2015 Elsevier Ltd. All rights reserved.
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