期刊
MOLECULAR ASPECTS OF MEDICINE
卷 47-48, 期 -, 页码 35-53出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mam.2016.01.003
关键词
miRNA; lncRNA; Hypoxia; Non-coding RNA; Cancer
资金
- Cancer Research UK [C602/A18974]
- Breast Cancer Research Foundation
- Deanship of Scientific Research (DSR), King Abdulaziz University, Saudi Arabia [G-1436-130-284]
- MRC [G0300648] Funding Source: UKRI
- Cancer Research UK [16466, 18974, 11359] Funding Source: researchfish
- Medical Research Council [G0300648] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0611-10163] Funding Source: researchfish
Recent investigations have highlighted the importance of the non-coding genome in regions of hypoxia in tumours. Such regions are frequently found in solid tumours, and are associated with worse patient survival and therapy resistance. Hypoxia stabilises the transcription factors, hypoxia inducible factors (HIF1 alpha and HIF2 alpha) which coordinate transcriptomic changes that occur in hypoxia. The changes in gene expression induced by HIF1a and HIF2a contribute to many of the hallmarks of cancer phenotypes and enable tumour growth, survival and invasion in the hypoxic tumour microenvironment. Non-coding RNAs, in particular microRNAs (miRNAs), which regulate mRNA stability and translation, and long-noncoding RNAs (lncRNAs), which have diverse functions including chromatin modification and transcriptional regulation, are also important in enabling the key hypoxia regulated processes. They have roles in the regulation of metabolism, angiogenesis, autophagy, invasion and metastasis in the hypoxic microenvironment. Furthermore, HIF1 alpha and HIF2 alpha expression and stabilisation are also regulated by both miRNAs and lncRNAs. Here we review the recent developments in the expression, regulation and functions of miRNAs, lncRNAs and other non-coding RNA classes in tumour hypoxia. (C) 2016 Elsevier Ltd. All rights reserved.
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